Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Accounts Payable and Accrued Expenses
Accrued research payables	$ 45,826	$ 46,274	$ 56,700
Accrued compensation and benefits	34,526	49,441
Accrued settlement costs	24,450
Accrued rent	19,061	16,744
Trade payables	14,474	17,817
Deferred revenue	7,643	9,760
Deferred compensation	3,262	3,027
Accrued restructuring	3,157	1,254
Accrued transaction processing	3,230	2,390
Other	18,714	22,823
Total	$ 174,343	$ 169,530