Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Accounts Payable and Accrued Expenses
Accrued research payables	$ 50,361	$ 46,274
Accrued compensation and benefits	30,169	49,441
Accrued settlement costs	22,103
Accrued rent	16,199	16,744
Trade payables	11,827	17,817
Deferred revenue	7,784	9,760
Deferred compensation	2,508	3,027
Accrued restructuring	637	1,254
Accrued transaction processing	2,243	2,390
Other	21,556	22,823
Total	$ 165,387	$ 169,530