Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Accounts Payable and Accrued Expenses
Accrued research payables	$ 55,908	$ 46,274
Accrued compensation and benefits	22,250	49,441
Accrued rent	16,313	16,744
Trade payables	13,907	17,817
Deferred revenue	7,713	9,760
Deferred compensation	2,654	3,027
Accrued restructuring	2,594	1,254
Accrued transaction processing	2,826	2,390
Other	34,429	22,823
Total	$ 158,594	$ 169,530