Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Accounts Payable and Accrued Expenses
Accrued research payables	$ 55,266	$ 46,274
Accrued compensation and benefits	17,406	49,441
Accrued rent	16,697	16,744
Trade payables	16,271	17,817
Deferred revenue	9,858	9,760
Deferred compensation	2,828	3,027
Accrued restructuring	883	1,254
Accrued transaction processing	2,989	2,390
Other	28,784	22,823
Total	$ 150,982	$ 169,530