Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Accounts Payable and Accrued Expenses
Accrued research payables	$ 48,319	$ 50,721
Accrued compensation and benefits	34,209	50,666
Trade payables	18,579	17,790
Deferred revenue	13,565	15,493
Accrued restructuring	5,714	11,708
Deferred compensation	4,800	7,579
Accrued transaction processing	3,112	2,986
Other	24,266	24,281
Total	$ 152,564	$ 181,224