Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands	Sep. 30, 2011	Dec. 31, 2010
Accounts Payable and Accrued Expenses
Accrued research payables	$ 55,808	$ 41,569
Accrued compensation and benefits	40,517	63,423
Trade payables	23,203	24,235
Deferred revenue	16,247	15,852
Deferred compensation	8,076	16,531
Accrued restructuring	7,595	3,196
Accrued transaction processing	3,583	3,336
Acquisition payment obligation	500	9,314
Other	24,470	17,653
Total	$ 179,999	$ 195,109