Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Accounts Payable and Accrued Expenses
Accrued research payables	$ 46,274	$ 56,736	$ 52,000
Accrued compensation and benefits	49,441	62,271
Accrued rent	16,744	19,169
Trade payables	17,817	19,547
Deferred revenue	9,760	13,836
Deferred compensation	3,027	3,918
Accrued restructuring	1,254	2,224
Accrued transaction processing	2,390	2,981
Other	22,823	18,529
Total	$ 169,530	$ 199,211