Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Accounts Payable and Accrued Expenses
Accrued research payables	$ 52,015	$ 38,591	$ 50,700
Accrued compensation and benefits	47,622	39,762
Trade payables	15,222	22,624
Accrued rent	19,938	10,947
Deferred revenue	12,533	12,177
Deferred compensation	4,552	4,650
Accrued restructuring	3,768	12,295
Accrued transaction processing	2,972	3,359
Other	17,309	20,657
Total	$ 175,931	$ 165,062