Accounts Payable and Accrued Expenses (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Accounts Payable and Accrued Expenses
Accrued compensation and benefits	$ 39,762	$ 50,666
Accrued research payables	38,591	50,721	41,600
Trade payables	22,624	17,790
Accrued restructuring	12,295	11,708
Deferred revenue	12,177	15,493
Deferred compensation	4,650	7,579
Accrued transaction processing	3,359	2,986
Other	31,604	24,281
Total	$ 165,062	$ 181,224