-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 MpflwcF5M5NNTDRP4Xxpt1/MlZx7+IkqjUh2tm7G01OgF6T87jaFt3+0QG6ZFbSc
 6Ar1ybk2jQr2PdBruWo1+w==

<SEC-DOCUMENT>0001225208-09-011302.txt : 20090504
<SEC-HEADER>0001225208-09-011302.hdr.sgml : 20090504
<ACCEPTANCE-DATETIME>20090504124836
ACCESSION NUMBER:		0001225208-09-011302
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090430
FILED AS OF DATE:		20090504
DATE AS OF CHANGE:		20090504

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Walton Andrew Scott
		CENTRAL INDEX KEY:			0001384994

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-11353
		FILM NUMBER:		09792461

	MAIL ADDRESS:	
		STREET 1:		430 SOUTH SPRING STREET
		CITY:			BURLINGTON
		STATE:			NC
		ZIP:			27215

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LABORATORY CORP OF AMERICA HOLDINGS
		CENTRAL INDEX KEY:			0000920148
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		IRS NUMBER:				133757370
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		358 S MAIN ST
		CITY:			BURLINGTON
		STATE:			NC
		ZIP:			27215
		BUSINESS PHONE:		3362291127

	MAIL ADDRESS:	
		STREET 1:		358 S MAIN ST
		CITY:			BURLINGTON
		STATE:			NC
		ZIP:			27215

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NATIONAL HEALTH LABORATORIES HOLDINGS INC
		DATE OF NAME CHANGE:	19940314
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-04-30</periodOfReport>

    <issuer>
        <issuerCik>0000920148</issuerCik>
        <issuerName>LABORATORY CORP OF AMERICA HOLDINGS</issuerName>
        <issuerTradingSymbol>LH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001384994</rptOwnerCik>
            <rptOwnerName>Walton Andrew Scott</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>531 SOUTH SPRING STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BURLINGTON</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27215</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>EVP</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-04-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3500</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>63.88</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>17195.804</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Pursuant to a plan in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ F. Samuel Eberts III</signatureName>
        <signatureDate>2009-05-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----