Exhibit 24.1

LABORATORY CORPORATION OF AMERICA HOLDINGS
POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS that the undersigned Officers and Directors of Laboratory Corporation of America Holdings, a Delaware corporation (the “Corporation”), hereby constitute and appoint Bradford T. Smith as the true and lawful agent and attorney-in-fact of the undersigned with full power and authority in said agents and attorneys-in-fact, and any one or more of them, to sign for the undersigned and in their respective names as Officers and as Directors of the Corporation the Registration Statement on Form S-8 of the Corporation to be filed with the Securities and Exchange Commission under the Securities Act of 1933, as amended, and any amendment or amendments to such Registration Statement, relating to securities of the Corporation acquired under or to be offered under the Laboratory Corporation of America Holdings 2008 Stock Incentive Plan, and the undersigned hereby ratify and confirm all acts taken by such agents and attorneys-in-fact, or any one or more of them, as herein authorized.

Date Name Title

May 7, 2008 /s/DAVID P. KING                          
David P. King President, Chief Executive Officer and Director
(Principle Executive Officer)

May 7, 2008 /s/ WILLIAM B. HAYES               
William B. Hayes Executive Vice President, Chief Financial Officer and Treasurer
(Principle Financial Officer)

May 7, 2008 /s/ THOMAS P. MAC MAHON    
Thomas P. Mac Mahon Chairman of the Board of Directors

May 7, 2008 /s/ BRADFORD T. SMITH           
Bradford T. Smith Director

May 7, 2008 /s/ KERRII B. ADNERSON*        
Kerrii B. Anderson Director

May 7, 2008 /s/ JEAN-LUC BELINGARD*        
Jean-Luc Belingard Director

May 7, 2008 /s/ WENDY E. LANE*                  
Wendy E. Lane Director

May 7, 2008 /s/ Robert E. Mittelstaedt, Jr.*     
Robert E. Mittelstaedt, Jr. Director

May 7, 2008 /s/ ARTHUR H. RUBENSTEIN*    
Arthur H. Rubenstein Director

May 7, 2008 /s/ M. KEITH WEIKEL*                
M. Keith Weikel Director

May 7, 2008 /s/ R. Sanders Williams, M.D.*      
R. Sanders Williams, M.D. Director