<SEC-DOCUMENT>0000921895-16-003396-index.html : 20160216
<SEC-HEADER>0000921895-16-003396.hdr.sgml : 20160215
<ACCEPTANCE-DATETIME>20160216155920
ACCESSION NUMBER:		0000921895-16-003396
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20160216
DATE AS OF CHANGE:		20160216

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Tobira Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001311596
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				030422069
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-87592
		FILM NUMBER:		161427714

	BUSINESS ADDRESS:	
		STREET 1:		701 GATEWAY BLVD
		STREET 2:		SUITE 300
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-741-6625

	MAIL ADDRESS:	
		STREET 1:		701 GATEWAY BLVD
		STREET 2:		SUITE 300
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tibira Therapeutics, Inc.
		DATE OF NAME CHANGE:	20150506

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Regado Biosciences Inc
		DATE OF NAME CHANGE:	20041215

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND L P
		CENTRAL INDEX KEY:			0000918923
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		IRS NUMBER:				363924731
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1 SANSOME ST
		STREET 2:		30TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		1 SANSOME ST
		STREET 2:		30TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>sc13ga407422tob_02162016.htm
<DESCRIPTION>AMENDMENT NO. 4 TO THE SCHEDULE 13G
<TEXT>
Document 1 - file: sc13ga407422tob_02162016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ex991to13ga407422tob_021616.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
Document 2 - file: ex991to13ga407422tob_021616.htm

</DOCUMENT>
</SEC-DOCUMENT>