EX-2 4 a2082250zex-2.htm EX-2
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EXHIBIT 2


TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS
DURING THE PAST SIXTY DAYS

Trade Date
   By
   For the
Account of
   Quantity
   Price per
Share
   Type of Trade
   Broker*
4/12/02   Partners   BVF   1,000   $ 9.3600   Purchase   INET
4/12/02   Partners   BVF   19,000   $ 9.4000   Purchase   JONE
4/12/02   Partners   BVF   5,000   $ 9.4459   Purchase   GKMC
4/15/02   Partners   BVF   500   $ 9.4740   Purchase   INET
4/16/02   Partners   BVF   6,000   $ 9.4500   Purchase   TWPT
4/16/02   Partners   BVF   2,000   $ 9.4500   Purchase   INET
4/22/02   Partners   BVF   1,600   $ 9.3622   Purchase   INET
4/23/02   Partners   BVF   500   $ 9.2463   Purchase   INET
4/23/02   Partners   BVF   7,000   $ 9.2800   Purchase   GKMC
4/24/02   Partners   BVF   800   $ 9.1200   Purchase   INET
4/25/02   Partners   BVF   85,000   $ 8.0990   Purchase   GKMC
4/25/02   Partners   BVF   60,000   $ 8.2250   Purchase   LTCO
4/26/02   Partners   BVF   1,000   $ 8.0000   Purchase   INET
4/26/02   Partners   BVF   24,500   $ 8.0303   Purchase   LTCO
4/29/02   Partners   BVF   1,200   $ 7.8982   Purchase   INET
4/29/02   Partners   BVF   25,500   $ 7.9100   Purchase   TWPT
4/29/02   Partners   BVF   7,000   $ 7.9400   Purchase   LTCO
4/29/02   Partners   BVF   36,400   $ 7.9617   Purchase   JONE
4/29/02   Partners   BVF   15,000   $ 7.9800   Purchase   GKMC
4/30/02   Partners   BVF   4,500   $ 7.9300   Purchase   INET
5/1/02   Partners   BVF   181,000   $ 8.0800   Purchase   GKMC
5/2/02   Partners   BVF   200   $ 7.8900   Purchase   INET
5/2/02   Partners   BVF   33,000   $ 8.0000   Purchase   JONE
5/3/02   Partners   BVF   2,500   $ 7.8262   Purchase   GKMC
5/3/02   Partners   BVF   4,400   $ 7.8703   Purchase   INET
5/3/02   Partners   BVF   64,500   $ 8.0500   Purchase   JONE
5/6/02   Partners   BVF   4,500   $ 7.8949   Purchase   INET
5/7/02   Partners   BVF   9,000   $ 7.6875   Purchase   GKMC
5/7/02   Partners   BVF   3,700   $ 7.6969   Purchase   INET
5/7/02   Partners   BVF   2,100   $ 7.7800   Purchase   INET
5/9/02   Partners   BVF   4,000   $ 7.6830   Purchase   LTCO
5/10/02   Partners   BVF   11,000   $ 7.6600   Purchase   LTCO
5/10/02   Partners   BVF   29,000   $ 7.6787   Purchase   GKMC
5/13/02   Partners   BVF   6,000   $ 7.7424   Purchase   GKMC
5/13/02   Partners   BVF   4,500   $ 7.7476   Purchase   INET
5/16/02   Partners   BVF   2,000   $ 7.5700   Purchase   INET
5/16/02   Partners   BVF   6,000   $ 7.5900   Purchase   GKMC
5/17/02   Partners   BVF   500   $ 7.5980   Purchase   INET
5/17/02   Partners   BVF   1,100   $ 7.6144   Purchase   INET
5/21/02   Partners   BVF   1,000   $ 7.5000   Purchase   INET
5/21/02   Partners   BVF   5,000   $ 7.5400   Purchase   GKMC
5/22/02   Partners   BVF   1,200   $ 7.5069   Purchase   INET
5/22/02   Partners   BVF   7,000   $ 7.5400   Purchase   GKMC
5/23/02   Partners   BVF   5,000   $ 7.5000   Purchase   INET

Page 1 of 4

5/23/02   Partners   BVF   7,000   $ 7.5460   Purchase   GKMC
5/24/02   Partners   BVF   3,000   $ 7.4000   Purchase   LTCO
5/24/02   Partners   BVF   14,400   $ 7.5601   Purchase   INET
5/28/02   Partners   BVF   12,100   $ 7.5000   Purchase   JONE
5/29/02   Partners   BVF   1,000   $ 7.4800   Purchase   GKMC
6/3/02   Partners   BVF   1,500   $ 7.4004   Purchase   INET
6/3/02   Partners   BVF   4,000   $ 7.3500   Purchase   GKMC
6/4/02   Partners   BVF   5,000   $ 7.3400   Purchase   GKMC
6/6/02   Partners   BVF   2,000   $ 7.2000   Purchase   GKMC
6/7/02   Partners   BVF   6,100   $ 7.1030   Purchase   GKMC
6/7/02   Partners   BVF   500   $ 7.1202   Purchase   INET
6/10/02   Partners   BVF   2,300   $ 7.0000   Purchase   INET
6/11/02   Partners   BVF   5,000   $ 6.6500   Purchase   GKMC
6/11/02   Partners   BVF   22,000   $ 6.5500   Purchase   TWPT
4/12/02   Partners   BVF2   13,000   $ 9.4000   Purchase   JONE
4/12/02   Partners   BVF2   3,000   $ 9.4459   Purchase   GKMC
4/15/02   Partners   BVF2   1,000   $ 9.4740   Purchase   INET
4/16/02   Partners   BVF2   4,000   $ 9.4500   Purchase   TWPT
4/16/02   Partners   BVF2   1,000   $ 9.4500   Purchase   INET
4/22/02   Partners   BVF2   1,000   $ 9.3622   Purchase   INET
4/23/02   Partners   BVF2   1,000   $ 9.2463   Purchase   INET
4/23/02   Partners   BVF2   5,000   $ 9.2800   Purchase   GKMC
4/25/02   Partners   BVF2   57,000   $ 8.0990   Purchase   GKMC
4/25/02   Partners   BVF2   40,000   $ 8.2250   Purchase   LTCO
4/26/02   Partners   BVF2   17,000   $ 8.0303   Purchase   LTCO
4/29/02   Partners   BVF2   18,000   $ 7.9100   Purchase   TWPT
4/29/02   Partners   BVF2   5,000   $ 7.9400   Purchase   LTCO
4/29/02   Partners   BVF2   25,000   $ 7.9617   Purchase   JONE
4/29/02   Partners   BVF2   10,000   $ 7.9800   Purchase   GKMC
4/30/02   Partners   BVF2   2,000   $ 7.9300   Purchase   INET
5/1/02   Partners   BVF2   121,000   $ 8.0800   Purchase   GKMC
5/2/02   Partners   BVF2   22,000   $ 8.0000   Purchase   JONE
5/3/02   Partners   BVF2   2,000   $ 7.8262   Purchase   GKMC
5/3/02   Partners   BVF2   2,000   $ 7.8703   Purchase   INET
5/3/02   Partners   BVF2   43,000   $ 8.0500   Purchase   JONE
5/6/02   Partners   BVF2   4,000   $ 7.8949   Purchase   INET
5/7/02   Partners   BVF2   6,000   $ 7.6875   Purchase   GKMC
5/7/02   Partners   BVF2   2,000   $ 7.6969   Purchase   INET
5/7/02   Partners   BVF2   1,000   $ 7.7800   Purchase   INET
5/9/02   Partners   BVF2   3,000   $ 7.6830   Purchase   LTCO
5/10/02   Partners   BVF2   7,000   $ 7.6600   Purchase   LTCO
5/10/02   Partners   BVF2   19,000   $ 7.6787   Purchase   GKMC
5/13/02   Partners   BVF2   4,000   $ 7.7424   Purchase   GKMC
5/13/02   Partners   BVF2   4,000   $ 7.7476   Purchase   INET
5/16/02   Partners   BVF2   1,000   $ 7.5700   Purchase   INET
5/17/02   Partners   BVF2   1,000   $ 7.5980   Purchase   INET
5/17/02   Partners   BVF2   1,000   $ 7.6144   Purchase   INET
5/21/02   Partners   BVF2   3,000   $ 7.5400   Purchase   GKMC

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5/22/02   Partners   BVF2   1,000   $ 7.5069   Purchase   INET
5/22/02   Partners   BVF2   5,000   $ 7.5400   Purchase   GKMC
5/23/02   Partners   BVF2   4,000   $ 7.5000   Purchase   INET
5/23/02   Partners   BVF2   5,000   $ 7.5460   Purchase   GKMC
5/24/02   Partners   BVF2   1,000   $ 7.4000   Purchase   LTCO
5/24/02   Partners   BVF2   9,000   $ 7.5601   Purchase   INET
5/28/02   Partners   BVF2   8,000   $ 7.5000   Purchase   JONE
6/3/02   Partners   BVF2   1,000   $ 7.4004   Purchase   INET
6/6/02   Partners   BVF2   2,000   $ 7.2000   Purchase   GKMC
6/7/02   Partners   BVF2   4,000   $ 7.1030   Purchase   GKMC
6/7/02   Partners   BVF2   1,000   $ 7.1202   Purchase   INET
6/10/02   Partners   BVF2   1,000   $ 7.0000   Purchase   INET
6/11/02   Partners   BVF2   4,000   $ 6.6500   Purchase   GKMC
6/11/02   Partners   BVF2   15,000   $ 6.5500   Purchase   TWPT
4/12/02   Partners   Investments   1,000   $ 9.3600   Purchase   INET
4/12/02   Partners   Investments   30,000   $ 9.4000   Purchase   JONE
4/12/02   Partners   Investments   8,000   $ 9.4459   Purchase   GKMC
4/15/02   Partners   Investments   1,000   $ 9.4740   Purchase   INET
4/16/02   Partners   Investments   9,000   $ 9.4500   Purchase   TWPT
4/16/02   Partners   Investments   2,000   $ 9.4500   Purchase   INET
4/22/02   Partners   Investments   2,000   $ 9.3622   Purchase   INET
4/23/02   Partners   Investments   1,000   $ 9.2463   Purchase   INET
4/23/02   Partners   Investments   12,000   $ 9.2800   Purchase   GKMC
4/25/02   Partners   Investments   131,000   $ 8.0990   Purchase   GKMC
4/25/02   Partners   Investments   92,000   $ 8.2250   Purchase   LTCO
4/26/02   Partners   Investments   38,000   $ 8.0303   Purchase   LTCO
4/29/02   Partners   Investments   1,000   $ 7.8982   Purchase   INET
4/29/02   Partners   Investments   40,000   $ 7.9100   Purchase   TWPT
4/29/02   Partners   Investments   12,000   $ 7.9400   Purchase   LTCO
4/29/02   Partners   Investments   57,000   $ 7.9617   Purchase   JONE
4/29/02   Partners   Investments   23,000   $ 7.9800   Purchase   GKMC
4/30/02   Partners   Investments   5,000   $ 7.9300   Purchase   INET
5/1/02   Partners   Investments   278,000   $ 8.0800   Purchase   GKMC
5/2/02   Partners   Investments   1,000   $ 7.8900   Purchase   INET
5/2/02   Partners   Investments   51,000   $ 8.0000   Purchase   JONE
5/3/02   Partners   Investments   4,000   $ 7.8262   Purchase   GKMC
5/3/02   Partners   Investments   6,000   $ 7.8703   Purchase   INET
5/3/02   Partners   Investments   100,000   $ 8.0500   Purchase   JONE
5/6/02   Partners   Investments   9,000   $ 7.8949   Purchase   INET
5/7/02   Partners   Investments   14,000   $ 7.6875   Purchase   GKMC
5/7/02   Partners   Investments   4,000   $ 7.6969   Purchase   INET
5/7/02   Partners   Investments   3,000   $ 7.7800   Purchase   INET
5/9/02   Partners   Investments   7,000   $ 7.6830   Purchase   LTCO
5/10/02   Partners   Investments   16,000   $ 7.6600   Purchase   LTCO
5/10/02   Partners   Investments   45,000   $ 7.6787   Purchase   GKMC
5/13/02   Partners   Investments   9,000   $ 7.7424   Purchase   GKMC
5/13/02   Partners   Investments   9,000   $ 7.7476   Purchase   INET
5/16/02   Partners   Investments   2,000   $ 7.5700   Purchase   INET
5/16/02   Partners   Investments   6,000   $ 7.5900   Purchase   GKMC

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5/17/02   Partners   Investments   1,000   $ 7.5980   Purchase   INET
5/17/02   Partners   Investments   2,000   $ 7.6144   Purchase   INET
5/21/02   Partners   Investments   7,000   $ 7.5400   Purchase   GKMC
5/22/02   Partners   Investments   1,000   $ 7.5069   Purchase   INET
5/22/02   Partners   Investments   12,000   $ 7.5400   Purchase   GKMC
5/23/02   Partners   Investments   8,000   $ 7.5000   Purchase   INET
5/23/02   Partners   Investments   12,000   $ 7.5460   Purchase   GKMC
5/24/02   Partners   Investments   3,000   $ 7.4000   Purchase   LTCO
5/24/02   Partners   Investments   22,000   $ 7.5601   Purchase   INET
5/28/02   Partners   Investments   19,000   $ 7.5000   Purchase   JONE
5/29/02   Partners   Investments   1,000   $ 7.4800   Purchase   GKMC
6/3/02   Partners   Investments   3,000   $ 7.4004   Purchase   INET
6/3/02   Partners   Investments   6,000   $ 7.3500   Purchase   GKMC
6/6/02   Partners   Investments   4,000   $ 7.2000   Purchase   GKMC
6/7/02   Partners   Investments   10,000   $ 7.1030   Purchase   GKMC
6/7/02   Partners   Investments   2,000   $ 7.1202   Purchase   INET
6/10/02   Partners   Investments   2,000   $ 7.0000   Purchase   INET
6/11/02   Partners   Investments   8,000   $ 6.6500   Purchase   GKMC
6/11/02   Partners   Investments   35,000   $ 6.5500   Purchase   TWPT
4/12/02   Partners   ILL10   3,000   $ 9.4000   Purchase   JONE
4/12/02   Partners   ILL10   1,000   $ 9.4459   Purchase   GKMC
4/16/02   Partners   ILL10   1,000   $ 9.4500   Purchase   TWPT
4/23/02   Partners   ILL10   1,000   $ 9.2800   Purchase   GKMC
4/25/02   Partners   ILL10   11,000   $ 8.0990   Purchase   GKMC
4/25/02   Partners   ILL10   8,000   $ 8.2250   Purchase   LTCO
4/26/02   Partners   ILL10   3,000   $ 8.0303   Purchase   LTCO
4/29/02   Partners   ILL10   4,000   $ 7.9100   Purchase   TWPT
4/29/02   Partners   ILL10   1,000   $ 7.9400   Purchase   LTCO
4/29/02   Partners   ILL10   5,000   $ 7.9617   Purchase   JONE
4/29/02   Partners   ILL10   2,000   $ 7.9800   Purchase   GKMC
5/1/02   Partners   ILL10   24,000   $ 8.0800   Purchase   GKMC
5/2/02   Partners   ILL10   4,000   $ 8.0000   Purchase   JONE
5/3/02   Partners   ILL10   9,000   $ 8.0500   Purchase   JONE
5/6/02   Partners   ILL10   1,000   $ 7.8949   Purchase   INET
5/7/02   Partners   ILL10   1,000   $ 7.6875   Purchase   GKMC
5/9/02   Partners   ILL10   1,000   $ 7.6830   Purchase   LTCO
5/10/02   Partners   ILL10   1,000   $ 7.6600   Purchase   LTCO
5/10/02   Partners   ILL10   4,000   $ 7.6787   Purchase   GKMC
5/13/02   Partners   ILL10   1,000   $ 7.7424   Purchase   GKMC
5/13/02   Partners   ILL10   1,000   $ 7.7476   Purchase   INET
5/21/02   Partners   ILL10   1,000   $ 7.5400   Purchase   GKMC
5/22/02   Partners   ILL10   1,000   $ 7.5400   Purchase   GKMC
5/23/02   Partners   ILL10   1,000   $ 7.5000   Purchase   INET
5/23/02   Partners   ILL10   1,000   $ 7.5460   Purchase   GKMC
5/24/02   Partners   ILL10   2,000   $ 7.5601   Purchase   INET
5/28/02   Partners   ILL10   2,000   $ 7.5000   Purchase   JONE
6/7/02   Partners   ILL10   1,000   $ 7.1030   Purchase   GKMC
6/11/02   Partners   ILL10   1,000   $ 6.6500   Purchase   GKMC
6/11/02   Partners   ILL10   3,000   $ 6.5500   Purchase   TWPT
*Broker Codes
GKMC —   Gerard Klauer
INET —   Instinet
JONE —   Jones & Associates
LTCO —   Ladenburg Thalman
TWPT —   Thomas Weisel Partners

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TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS DURING THE PAST SIXTY DAYS