Exhibit A
JOINT FILING AGREEMENT
 

The undersigned agree that Schedule 13G, dated December 15, 2008, relating to the Common Stock of SPPI shall be filed on behalf of the undersigned.

Dated: December 15, 2008

BIOTECHNOLOGY VALUE FUND, L.P.
By:	BVF Partners, L.P., its general partner
	By:	BVF Inc., its general partner
	By:	/s/ Mark N. Lampert
		Mark N. Lampert, President
BIOTECHNOLOGY VALUE FUND II, L.P.
By:	BVF Partners, L.P., its general partner
	By:	BVF Inc., its general partner
	By:	/s/ Mark N. Lampert
		Mark N. Lampert, President
BVF INVESTMENTS, L.L.C.
By:	BVF Partners, L.P., its manager
	By:	BVF Inc., its general partner
	By:	/s/ Mark N. Lampert
		Mark N. Lampert, President
INVESTMENT 10, L.L.C.
By:	BVF Partners, L.P., its investment manager
	By:	BVF Inc., its general partner
	By:	/s/ Mark N. Lampert
		Mark N. Lampert, President
BVP PARTNERS L.P.
By:	BVF Inc., its general partner
	By:	/s/ Mark N. Lampert
		Mark N. Lampert, President
BVF INC.
	By:	/s/ Mark N. Lampert
		Mark N. Lampert, President