EX-99 2 exhibit_99.htm

EXHIBIT 1

AGREEMENT REGARDING JOINT FILING

                The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, Investment 10, L.L.C., an Illinois limited liability company, BVF Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by Schedule 13G, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them.

Dated:   April 14, 2006

 

 

BIOTECHNOLOGY VALUE FUND, L.P.

 

 

By:

 

BVF Partners L.P., its general partner

 

 

 

 

By:

 

BVF Inc., its general partner

 

 

 

 

 

 

By:

 

/s/  
MARK N. LAMPERT      
               
Mark N. Lampert
President

 

 

BIOTECHNOLOGY VALUE FUND II, L.P.

 

 

By:

 

BVF Partners L.P., its general partner

 

 

 

 

By:

 

BVF Inc., its general partner

 

 

 

 

 

 

By:

 

/s/  
MARK N. LAMPERT      
               
Mark N. Lampert
President

 

 

BVF INVESTMENTS, L.L.C.

 

 

By:

 

BVF Partners L.P., its manager

 

 

 

 

By:

 

BVF Inc., its general partner

 

 

 

 

 

 

By:

 

/s/  
MARK N. LAMPERT      
               
Mark N. Lampert
President

 

 

INVESTMENT 10, L.L.C.

 

 

By:

 

BVF Partners L.P., its attorney-in-fact

 

 

 

 

By:

 

BVF Inc., its general partner

 

 

 

 

 

 

By:

 

/s/  
MARK N. LAMPERT      
               
Mark N. Lampert
President

 

 

BVF PARTNERS L.P.

 

 

By:

 

BVF Inc., its general partner

 

 

 

 

 

 

By:

 

/s/  
MARK N. LAMPERT      
               
Mark N. Lampert
President

 

 

BVF INC.

 

 

 

 

 

 

By:

 

/s/  
MARK N. LAMPERT      
               
Mark N. Lampert
President