SC 13G/A 1 bvf_genaera-sc13g.txt SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1) * Genaera Corporation ------------------- (Name of Issuer) COMMON STOCK ------------ (Title of Class of Securities) 36867G100 --------- (CUSIP Number) October 6, 2003 --------------- Date of Event which Requires Filing of this Statement Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [x] Rule 13d-1(c) [ ] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 2 of 12 Pages -------------------------------- -------------------------- -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON Biotechnology Value Fund, L.P. I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (entities only) -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [X] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware -------------------------------------------------------------------------------- 5 SOLE VOTING POWER NUMBER OF SHARES 0 BENEFICIALLY ----------------------------------------------------------------- OWNED BY EACH 6 SHARED VOTING POWER REPORTING PERSON 509,200 shares (1) WITH ---------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 0 ---------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 509,200 shares (1) -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 509,200 shares (1) -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 1.13%(1)(2) -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) PN -------------------------------------------------------------------------------- See attached for footnotes. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 3 of 12 Pages -------------------------------- -------------------------- -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON Biotechnology Value Fund II, L.P. I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (entities only) -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [X] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware -------------------------------------------------------------------------------- 5 SOLE VOTING POWER NUMBER OF SHARES 0 BENEFICIALLY ---------------------------------------------------------------- OWNED BY EACH 6 SHARED VOTING POWER REPORTING PERSON 321,000 shares (1) WITH ---------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 0 ---------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 321,000 shares (1) -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 321,000 shares (1) -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 0.71%(1)(2) -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) PN -------------------------------------------------------------------------------- See attached for footnotes. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 4 of 12 Pages -------------------------------- -------------------------- -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON BVF Investments, L.L.C. I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (entities only) -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [X] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware -------------------------------------------------------------------------------- 5 SOLE VOTING POWER NUMBER OF SHARES 0 BENEFICIALLY ----------------------------------------------------------------- OWNED BY EACH 6 SHARED VOTING POWER REPORTING PERSON 784,000 shares (1) WITH ----------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 0 ----------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 784,000 shares (1) -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 784,000 shares (1) -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 1.73%(1)(2) -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) OO -------------------------------------------------------------------------------- See attached for footnotes. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 5 of 12 Pages -------------------------------- -------------------------- -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON Investment 10, LLC I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (entities only) -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [X] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Illinois -------------------------------------------------------------------------------- 5 SOLE VOTING POWER NUMBER OF SHARES 0 BENEFICIALLY ---------------------------------------------------------------- OWNED BY EACH 6 SHARED VOTING POWER REPORTING PERSON 81,000 shares(1) WITH ---------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 0 ---------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 81,000 shares (1) -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 81,000 shares (1) -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 0.18%(1)(2) -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) OO -------------------------------------------------------------------------------- See attached for footnotes. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 6 of 12 Pages -------------------------------- -------------------------- -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON BVF Partners L.P. I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (entities only) -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [X] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware -------------------------------------------------------------------------------- 5 SOLE VOTING POWER NUMBER OF SHARES 0 BENEFICIALLY ---------------------------------------------------------------- OWNED BY EACH 6 SHARED VOTING POWER REPORTING PERSON 1,695,200 shares (1) WITH ---------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 0 ---------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 1,695,200 shares (1) -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,695,200 shares (1) -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 3.75%(1)(2) -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) PN -------------------------------------------------------------------------------- See attached for footnotes. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 7 of 12 Pages -------------------------------- -------------------------- -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON BVF Inc. I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (entities only) -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [X] (b) [ ] -------------------------------------------------------------------------------- 3 SEC USE ONLY -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware -------------------------------------------------------------------------------- 5 SOLE VOTING POWER NUMBER OF SHARES 0 BENEFICIALLY ---------------------------------------------------------------- OWNED BY EACH 6 SHARED VOTING POWER REPORTING PERSON 1,695,200 shares (1) WITH ---------------------------------------------------------------- 7 SOLE DISPOSITIVE POWER 0 ---------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 1,695,200 shares (1) -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,695,200 shares (1) -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructions) [ ] -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 3.75%(1)(2) -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (See Instructions) CO -------------------------------------------------------------------------------- See attached for footnotes. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 8 of 12 Pages -------------------------------- -------------------------- The following footnotes relate to pages 2 thru 7: (1) With respect to each Reporting Person, the following securities are held, as follows (See Item 2(a) for defined terms for each entity): Security Type BVF BVF2 Investments Investment Partners BVF Inc. 10 -------------------------------------------------------------------------------- Common Stock 149,200 93,000 230,000 23,000 495,200 495,200 May Warrants 270,000 171,000 415,500 43,500 900,000 900,000 November Warrants 90,000 57,000 138,500 14,500 300,000 300,000 May Warrants ------------ The May Warrants may be exercised at any time until expiration on May 23, 2008 for shares of the issuer's Common Stock at an exercise price of $1.37 per share (subject to adjustment). Please refer to the Form of May Warrant, which is filed as an exhibit to the issuer's Form 8-K dated May 28, 2003, for additional terms of the May Warrants. November Warrants ----------------- Prior to November 23, 2004, the November Warrants may only be exercised for shares of Common Stock if the holder exercises the warrants on a net exercise basis as provided in Section A(1) of the November Warrants. Under the net exercise provision the value of the underlying Common Stock for which the November Warrants are exercisable is unknown until the actual exercise of the November Warrants. Therefore, if the Reporting Person actually exercises the November Warrants prior to November 23, 2004, it is not possible to determine the exact number of shares that the Reporting Person will receive until the value of the underlying Common Stock is fixed upon exercise. For purposes of this Amendment to Schedule 13G, the maximum number of shares of Common Stock underlying the November Warrants for each Reporting Person is disclosed even though the Reporting Person will, in fact, receive a lesser number of shares of Common Stock should the November Warrants be exercised on a net exercise basis. Beginning on November 23, 2004 and until expiration of the November Warrants on May 23, 2008, the November Warrants may also be exercised for shares of Common Stock by payment of the exercise price of $1.37 (subject to adjustment) as specified in the November Warrants and up to all of the shares of Common Stock underlying the November Warrants for the Reporting Person may be issued. Please refer to the Form of November Warrant, which is filed as an exhibit to the issuer's Form 8-K dated May 28, 2003, for additional terms of the November Warrants. (2) Percentage calculations are based on 44,049,241 shares of Common Stock outstanding and 1,200,000 shares of Common Stock issuable upon exercise of the May Warrants and the November Warrants held by the Reporting Persons. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 10 of 12 Pages -------------------------------- -------------------------- Item 1(a). Name of Issuer: Genaera Corporation Item 1(b). Address of Issuer's Principal Executive Offices: 5110 Campus Drive Plymouth Meeting, PA 19462 Item 2(a). Names of Person Filing This Schedule 13G is being filed on behalf of the following persons* (the "Reporting Persons"): (i) Biotechnology Value Fund, L.P. ("BVF") (ii) Biotechnology Value Fund II, L.P. ("BVF2") (iii) BVF Investments, L.L.C. ("Investments") (iv) Investment 10, L.L.C. ("Investment 10") (v) BVF Partners L.P. ("Partners") (vi) BVF Inc. ("BVF Inc.") * Attached as Exhibit 1 to the original Schedule 13G filed on June 9, 2003 is a copy of an agreement among the Reporting Persons that the original Schedule 13G and any amendments thereto shall be filed on behalf of each of them. Item 2(b). Address of Principal Business Office or, if none, Residence: The principal business office of the Reporting Persons comprising the group filing this Schedule 13G is located at 227 West Monroe Street, Suite 4800, Chicago, Illinois, 60606. Item 2(c). Citizenship or Place of Organization: BVF: a Delaware limited partnership BVF2: a Delaware limited partnership Investments: a Delaware limited liability company Investment 10: an Illinois limited liability company Partners: a Delaware limited partnership BVF Inc.: a Delaware corporation -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 11 of 12 Pages -------------------------------- -------------------------- Item 2(d). Title of Class of Securities: This Amendment to Schedule 13G is being filed with respect to the Common Stock, par value $.002 per share (the "Common Stock"), of Genaera Corporation. The Reporting Persons' percentage ownership of Common Stock is based on 44,049,241 shares of Common Stock being outstanding and 1,200,000 warrants beneficially owned by the Reporting Persons. See the discussion in footnote (1) for a further description of the warrants. Item 2(e). CUSIP Number: 36867G100 Item 3. If this Statement is Filed Pursuant to Rule 13d-1(B), or 13d-2(B) or (C) Check Whether the Person Filing is: One of the Following Not applicable as this Schedule 13G is filed pursuant to Rule 13d-1(c). Item 4. Ownership The information in items 1 and 5 through 11 on the cover pages (pp. 2 - 7) on this Amendment to Schedule 13G is hereby incorporated by reference. Item 5. Ownership of 5 Percent or Less of a Class If this statement is being filed to report the fact that as of the date hereof the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities check the following. |X| Item 6. Ownership of More than 5 Percent on Behalf of Another Person Pursuant to the operating agreement of Investments, Partners is authorized, among other things, to invest funds of Ziff Asset Management, L.P., the majority member of Investments, in shares of Common Stock and Warrants described herein and to vote and exercise dispositive power over those securities. Partners and BVF Inc. share voting and dispositive power over the shares of Common Stock and the Warrants beneficially owned by BVF, BVF2, Investments and those owned by Investment 10, on whose behalf Partners acts as investment manager and, accordingly, Partners and BVF Inc. have beneficial ownership of all of the shares of Common Stock and Warrants held by such parties. Item 7. Identification and Classification of the Subsidiary Which Acquired the Securities Being Reported on By the Parent Holding Company Not Applicable. Item 8. Identification and Classification of Members of the Group Not Applicable. Item 9. Notice of Dissolution of Group Not Applicable. -------------------------------- -------------------------- CUSIP No. 36867G100 13G Page 12 of 12 Pages -------------------------------- -------------------------- Item 10. Certification By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated October 9, 2003 BIOTECHNOLOGY VALUE FUND, L.P. By: BVF Partners L.P., its general partner By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ---------------------------- Mark N. Lampert President BIOTECHNOLOGY VALUE FUND II, L.P. By: BVF Partners L.P., its general partner By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ---------------------------- Mark N. Lampert President BVF INVESTMENTS, L.L.C. By: BVF Partners L.P., its manager By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ---------------------------- Mark N. Lampert President INVESTMENT 10, L.L.C. By: BVF Partners L.P., its attorney-in-fact By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ---------------------------- Mark N. Lampert President BVF PARTNERS L.P. By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ---------------------------- Mark N. Lampert President BVF INC. By: /s/ MARK N. LAMPERT ---------------------------- Mark N. Lampert President