-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, QENiIduFd/IQsiI0dkNnJCkct2gkaK2JaovfiY1lMvMtBsz4Nqul2OeuKacfSdJD GEIvNu3A/1KEYj3YSp4HeA== 0000898430-97-001625.txt : 19970423 0000898430-97-001625.hdr.sgml : 19970423 ACCESSION NUMBER: 0000898430-97-001625 CONFORMED SUBMISSION TYPE: SC 13D PUBLIC DOCUMENT COUNT: 3 FILED AS OF DATE: 19970422 SROS: NASD GROUP MEMBERS: BIOTECHNOLOGY VALUE FUND L P ET AL GROUP MEMBERS: BVF INC. GROUP MEMBERS: BVF PARTNERS L.P. SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: SYNAPTIC PHARMACEUTICAL CORP CENTRAL INDEX KEY: 0000884939 STANDARD INDUSTRIAL CLASSIFICATION: SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731] IRS NUMBER: 222859704 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13D SEC ACT: 1934 Act SEC FILE NUMBER: 005-45417 FILM NUMBER: 97585285 BUSINESS ADDRESS: STREET 1: 215 COLLEGE RD CITY: PARAMUS STATE: NJ ZIP: 07652 BUSINESS PHONE: 2012611331 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: BIOTECHNOLOGY VALUE FUND L P ET AL CENTRAL INDEX KEY: 0000918923 STANDARD INDUSTRIAL CLASSIFICATION: INVESTMENT ADVICE [6282] IRS NUMBER: 363924731 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: SC 13D BUSINESS ADDRESS: STREET 1: ONE SANSOME STREET STREET 2: 39TH FLOOR CITY: SAN FRANCISCO STATE: CA ZIP: 94104 BUSINESS PHONE: 415-288-2395 MAIL ADDRESS: STREET 1: ONE SANSOME STREET STREET 2: 39TH FLOOR CITY: SAN FRANCISCO STATE: CA ZIP: 94104 SC 13D 1 SCHEDULE 13D SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (RULE 13d-101) UNDER THE SECURITIES EXCHANGE ACT OF 1934/1/ SYNAPTIC PHARMACEUTICAL CORPORATION ----------------------------------- (Name of Issuer) Common Stock ------------ (Title of Class of Securities) 87156 R 109 ----------- (CUSIP Number) Hope Flack BVF Partners L.P. 333 West Wacker Drive, Suite 1600 Chicago, Illinois 60606 (312) 263-7777 -------------------------------------------- (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications) March 19, 1997 -------------- (Date of Event which Requires Filing of this Statement) If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ]. Note: Six copies of this statement, including all exhibits, should be filed with the Commission. See Rule 13d-1(a) for other parties to whom copies are to be sent. (Continued on following pages) (Page 1 of 8 Pages) - -------------------- /1/ The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 2 of 8 Pages - ------------------------ ----------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS BIOTECHNOLOGY VALUE FUND, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [X] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS* WC - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) [ ] - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION DELAWARE - -------------------------------------------------------------------------------- NUMBER 7 SOLE VOTING POWER OF -0- SHARES ----------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 378,126 REPORTING ----------------------------------- PERSON 9 SOLE DISPOSITIVE POWER WITH -0- - --------------- ----------------------------------- 10 SHARED DISPOSITIVE POWER 378,126 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 378,126 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 4.9% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTIONS BEFORE FILLING OUT! - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 3 of 8 Pages - ------------------------ ----------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS BVF PARTNERS L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [X] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS* OO - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) [ ] - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION DELAWARE - -------------------------------------------------------------------------------- NUMBER 7 SOLE VOTING POWER OF -0- SHARES ----------------------------------- BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 726,526 REPORTING ----------------------------------- PERSON 9 SOLE DISPOSITIVE POWER WITH -0- ----------------------------------- 10 SHARED DISPOSITIVE POWER 726,526 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 726,526 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 9.5% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON* PN - --------------------------------------------------------------------- * SEE INSTRUCTIONS BEFORE FILLING OUT! - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 4 of 8 Pages - ------------------------ ----------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSONS S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS BVF INC. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [X] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 SOURCE OF FUNDS* WC, OO - -------------------------------------------------------------------------------- 5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) [ ] - -------------------------------------------------------------------------------- 6 CITIZENSHIP OR PLACE OF ORGANIZATION DELAWARE - -------------------------------------------------------------------------------- NUMBER 7 SOLE VOTING POWER OF -0- SHARES ------------------------------------ BENEFICIALLY 8 SHARED VOTING POWER OWNED BY 726,526 REPORTING ----------------------------------- PERSON 9 SOLE DISPOSITIVE POWER WITH -0- ----------------------------------- 10 SHARED DISPOSITIVE POWER 726,526 - -------------------------------------------------------------------------------- 11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 726,526 - -------------------------------------------------------------------------------- 12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11 9.5% - -------------------------------------------------------------------------------- 14 TYPE OF REPORTING PERSON* IA, CO - --------------------------------------------------------------------- * SEE INSTRUCTIONS BEFORE FILLING OUT! - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 5 of 8 Pages - ------------------------ ----------------------- ITEM 1. SECURITY AND ISSUER. This Statement on Schedule 13D (this "Statement") relates to the Common Stock, par value $0.01 per share (the "Stock"), of Synaptic Pharmaceutical Corporation, a Delaware corporation ("Synaptic"). The principle executive office of Synaptic is located at 215 College Road, Paramus, New Jersey 07652- 1431. ITEM 2. IDENTITY AND BACKGROUND. The persons filing this Statement, the persons enumerated in Instruction C of Schedule 13D and, where applicable, their respective places of organization, general partners, directors, executive officers and controlling persons, and certain information regarding each of them, are as follows: (a) Biotechnology Value Fund, L.P., a Delaware limited partnership ("BVF, L.P."), BVF Partners L.P., a Delaware limited partnership ("Partners"), BVF Inc., a Delaware corporation ("BVF Inc."), and Mark N. Lampert, an individual ("Lampert") (collectively, the "Reporting Persons"). (b) The business address of BVF, L.P. and Partners is 333 West Wacker Drive, Suite 1600, Chicago, Illinois 60606. The business address of BVF Inc. and Lampert is One Sansome Street, 39th Floor, San Francisco, California 94104. (c) Partners is the general partner of BVF, L.P., which is an investment limited partnership. BVF Inc. is an investment adviser to and general partner of Partners. Lampert is the sole shareholder, sole director and an officer of BVF Inc. (d) During the last five years, none of such persons has been convicted in a criminal proceeding (excluding traffic violations and similar misdemeanors). (e) During the last five years, none of such persons was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. (f) Lampert is a citizen of the United States of America. - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 6 of 8 Pages - ------------------------ ----------------------- ITEM 3. SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION. Since February 5, 1997, Partners, in its capacity as general partner of BVF, L.P., has purchased on behalf of such limited partnership an aggregate number of 277,500 shares of the Stock for an aggregate consideration of $3,637,073.70, utilizing funds provided by BVF, L.P., from its working capital pursuant to the terms of its limited partnership agreement with Partners. In addition, Partners, in its capacity as investment manager with respect to certain managed accounts, has purchased on behalf of such managed accounts an aggregate number of 256,000 shares of the Stock for an aggregate consideration of $3,377,386.50, utilizing funds under management by Partners pursuant to an investment management agreement between Partners and such managed accounts. ITEM 4. PURPOSE OF TRANSACTION. The sole purpose of the acquisitions of the Stock reported herein is and was for investment. The Reporting Persons did not at the time of such acquisitions of the Stock, and do not presently, have any plan to acquire control of Synaptic. The Reporting Persons may acquire or dispose of additional shares of the Stock from time to time. ITEM 5. INTEREST IN SECURITIES OF THE ISSUER. (a) BVF, L.P., beneficially owns 378,126 shares of the Stock, Partners beneficially owns 726,526 shares of the Stock, and BVF Inc. beneficially owns 726,526 shares of the Stock, approximately 4.9%, 9.5% and 9.5%, respectively, of the aggregate number of shares outstanding as of April 22, 1997. (b) BVF, L.P., shares voting and dispositive power over the 378,126 shares of the Stock it beneficially owns with Partners. Partners and BVF Inc. share voting and dispositive power over the 726,526 shares of the Stock they beneficially own with, in addition to BVF, L.P., the managed accounts on whose behalf Partners, as investment manager, purchased such shares. The managed accounts on whose behalf Partners owns shares of the Stock are Investment 10 L.L.C., an Illinois limited liability company ("ILL10"), Palamundo, L.D.C., a limited duration company organized under the laws of the Cayman Islands ("Palamundo"), ZPG Securities, L.L.C., a New York limited liability company ("ZPG") and Biotechnology Value Fund, Ltd., a Cayman Islands Corporation ("BVF Ltd."). ILL10, Palamundo, ZPG and BVF Ltd. are collectively referred to herein as the "Accounts." The Accounts specialize in holding biotechnology stocks for investment purposes and the business address of each is % BVF Partners L.P., 333 West Wacker Drive, Suite 1600, Chicago, Illinois 60606. (c) Exhibit B attached hereto contains information as to all transactions in the Stock by the Reporting Persons during the past 60 days. All such transactions were made for - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 7 of 8 Pages - ------------------------ ----------------------- cash in open market, over-the-counter transactions. No other transactions in the Stock have been effected by the Reporting Persons during the past 60 days. (d) The Accounts are entitled to receive dividends and any sale proceeds with respect to the Stock in proportion to their respective ownership interests therein. ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO SECURITIES OF THE ISSUER. Partners is the general partner of BVF, L.P. pursuant to a limited partnership agreement which authorizes Partners, among other things, to invest the funds of BVF, L.P. in the Stock and to vote and dispose of the Stock. Pursuant to such limited partnership agreement, Partners is entitled to allocations based on assets under management and realized and unrealized gains thereon. Pursuant to investment management agreements with the Accounts, Partners and BVF Inc. have the authority, among other things, to invest funds of the Accounts in the Stock and to vote and dispose of the Stock. Pursuant to such agreements, Partners and BVF Inc. receive fees based on assets under management and realized and unrealized gains thereon. BVF Inc. is the general partner of Partners and may be deemed to own beneficially securities over which Partners exercises voting and dispositive power. ITEM 7. MATERIAL TO BE FILED AS EXHIBITS. Exhibit A - Agreement Regarding Joint Filing Exhibit B - Transactions in the Stock by the Reporting Persons during the last 60 days. - ------------------------ ----------------------- CUSIP NO. 87156 R 109 13D Page 8 of 8 Pages - ------------------------ ----------------------- After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: April 22, 1997 BIOTECHNOLOGY VALUE FUND, L.P. By: BVF Partners L.P., its general partner By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT --------------------------------- Mark N. Lampert President BVF PARTNERS L.P. By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ------------------------------------- Mark N. Lampert President BVF INC. By: /s/ MARK N. LAMPERT ------------------------------------- Mark N. Lampert President EX-99.A 2 AGREEMENT REGARDING JOINT FILING EXHIBIT A AGREEMENT REGARDING JOINT FILING -------------------------------- The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, and BVF Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the statement containing the information required by Schedule 13D, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them. Dated: April 22, 1997 BIOTECHNOLOGY VALUE FUND, L.P. By: BVF Partners L.P., its general partner By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ------------------------------------- Mark N. Lampert President BVF PARTNERS L.P. By: BVF Inc., its general partner By: /s/ MARK N. LAMPERT ----------------------------------------- Mark N. Lampert President BVF INC. By: /s/ MARK N. LAMPERT ------------------------------------- Mark N. Lampert President EX-99.B 3 TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS EXHIBIT B TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS -------------------------------------------------- DURING THE LAST 60 DAYS -----------------------
- -------------------------------------------------------------------------------------- Settlement For the Price - ---------- By ------- Quantity ----- Date -- Account of -------- per Type of Trade Broker ---- ---------- --- ------------- ------ Share --------- ====================================================================================== 02/10/97 Partners BVF, L.P. 26,000 13.0847 Purchase MLCO - -------------------------------------------------------------------------------------- 02/10/97 Partners BVF, Ltd. 5,000 13.0847 Purchase MLCO - -------------------------------------------------------------------------------------- 02/12/97 Partners BVF, L.P. 17,500 13.625 Purchase MLCO - -------------------------------------------------------------------------------------- 02/12/97 Partners BVF, Ltd. 5,000 13.625 Purchase MLCO - -------------------------------------------------------------------------------------- 02/21/97 Partners BVF, L.P. 8,500 13.75 Purchase MLCO - -------------------------------------------------------------------------------------- 02/21/97 Partners BVF, Ltd. 4,000 13.75 Purchase MLCO - -------------------------------------------------------------------------------------- 02/27/97 Partners BVF, L.P. 5,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 02/28/97 Partners ILL10 2,500 13.625 Purchase MLCO - -------------------------------------------------------------------------------------- 02/28/97 Partners BVF, Ltd. 2,500 13.625 Purchase MLCO - -------------------------------------------------------------------------------------- 03/06/97 Partners BVF, L.P. 55,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 03/06/97 Partners ILL10 8,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 03/06/97 Partners BVF, Ltd. 30,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 03/19/97 Partners BVF, L.P. 7,000 14.4645 Purchase MLCO - -------------------------------------------------------------------------------------- 03/19/97 Partners PAL 15,000 14.4643 Purchase MLCO - -------------------------------------------------------------------------------------- 03/19/97 Partners ZPG 10,000 14.4645 Purchase MLCO - -------------------------------------------------------------------------------------- 03/19/97 Partners BVF, Ltd. 3,000 14.4645 Purchase MLCO - -------------------------------------------------------------------------------------- 03/20/97 Partners BVF, L.P. 1,000 14.25 Purchase MLCO - -------------------------------------------------------------------------------------- 03/20/97 Partners PAL 3,000 14.25 Purchase MLCO - -------------------------------------------------------------------------------------- 03/20/97 Partners ZPG 5,000 14.25 Purchase MLCO - -------------------------------------------------------------------------------------- 03/31/97 Partners BVF, L.P. 6,000 13.875 Purchase MLCO - -------------------------------------------------------------------------------------- 03/31/97 Partners BVF, Ltd. 4,000 13.875 Purchase MLCO - -------------------------------------------------------------------------------------- 04/02/97 Partners BVF, L.P. 4,000 13.8125 Purchase PFTC - -------------------------------------------------------------------------------------- 04/02/97 Partners ZPG 1,000 13.8125 Purchase PFTC - -------------------------------------------------------------------------------------- 04/02/97 Partners BVF, Ltd. 3,000 13.8125 Purchase PFTC - -------------------------------------------------------------------------------------- 04/09/97 Partners BVF, L.P. 5,000 13.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/09/97 Partners ILL10 5,000 13.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/10/97 Partners BVF, L.P. 21,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 04/10/97 Partners PAL 4,000 13.25 Purchase MLCO - --------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------- Settlement For the Price - ---------- By ------- Quantity ----- Date -- Account of -------- per Type of Trade Broker ---- ---------- --- ------------- ------ Share --------- ====================================================================================== - -------------------------------------------------------------------------------------- 04/10/97 Partners ZPG 3,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 04/10/97 Partners BVF, Ltd. 12,000 13.25 Purchase MLCO - -------------------------------------------------------------------------------------- 04/14/97 Partners ILL10 4,000 13.125 Purchase MLCO - -------------------------------------------------------------------------------------- 04/14/97 Partners BVF, Ltd. 6,000 13.125 Purchase MLCO - -------------------------------------------------------------------------------------- 04/16/97 Partners BVF, L.P. 10,000 13.125 Purchase MLCO - -------------------------------------------------------------------------------------- 04/16/97 Partners BVF, Ltd. 5,000 13.125 Purchase MLCO - -------------------------------------------------------------------------------------- 04/17/97 Partners BVF, L.P. 18,500 12.875 Purchase MLCO - -------------------------------------------------------------------------------------- 04/17/97 Partners ILL10 5,000 12.875 Purchase MLCO - -------------------------------------------------------------------------------------- 04/17/97 Partners PAL 6,000 12.875 Purchase MLCO - -------------------------------------------------------------------------------------- 04/17/97 Partners ZPG 3,000 12.875 Purchase MLCO - -------------------------------------------------------------------------------------- 04/17/97 Partners BVF, Ltd. 10,000 12.875 Purchase MLCO - -------------------------------------------------------------------------------------- 04/17/97 Partners BVF, L.P. 10,000 12.875 Purchase VECT - -------------------------------------------------------------------------------------- 04/18/97 Partners BVF, L.P. 5,000 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/18/97 Partners BVF, L.P. 59,500 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/18/97 Partners ILL10 7,500 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/18/97 Partners ZPG 3,000 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/18/97 Partners BVF, Ltd. 37,000 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/21/97 Partners BVF, L.P. 11,000 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/21/97 Partners ILL10 2,000 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/21/97 Partners PAL 2,000 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/21/97 Partners BVF, Ltd. 5,000 12.625 Purchase MLCO - -------------------------------------------------------------------------------------- 04/23/97 Partners BVF, L.P. 2,500 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/23/97 Partners BVF, Ltd. 2,500 12.625 Purchase MRST - -------------------------------------------------------------------------------------- 04/24/97 Partners BVF, L.P. 5,000 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/24/97 Partners ILL10 5,000 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/24/97 Partners PAL 2,000 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/24/97 Partners ZPG 3,000 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/24/97 Partners BVF, Ltd. 20,000 12.625 Purchase VECT - -------------------------------------------------------------------------------------- 04/24/97 Partners BVF, Ltd. 3,000 12.625 Purchase MRST - --------------------------------------------------------------------------------------
MLCO = Merrill Lynch & Co. MRST = Mr. Stock PFTC = Preferred Technologies VECT = Vector Securities -----END PRIVACY-ENHANCED MESSAGE-----