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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TVWj2bPO4furYSmy/XtfpGYV01hOMS3FbhvdTScmftaQqbEeM2fBGpjJuuxhNLii
 sB6QaiHGb/O3QsAQtPeB5A==

<SEC-DOCUMENT>0001239916-03-000004.txt : 20031120
<SEC-HEADER>0001239916-03-000004.hdr.sgml : 20031120
<ACCEPTANCE-DATETIME>20031120151047
ACCESSION NUMBER:		0001239916-03-000004
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031118
FILED AS OF DATE:		20031120

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			UPRICHARD DAVID C
		CENTRAL INDEX KEY:			0001239916

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23736
		FILM NUMBER:		031015423

	MAIL ADDRESS:	
		STREET 1:		12 PINE STREET
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19106

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GUILFORD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000918066
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521841960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c0001239916d20031120f4f.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-11-18</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000918066</issuerCik><issuerName>GUILFORD PHARMACEUTICALS INC</issuerName>        <issuerTradingSymbol>GLFD</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001239916</rptOwnerCik><rptOwnerName>UPRICHARD DAVID C</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>C/O GUILFORD PHARMACUTICALS INC.</rptOwnerStreet1><rptOwnerStreet2>6611 TRIBUTARY STREET</rptOwnerStreet2><rptOwnerCity>BALTIMORE</rptOwnerCity><rptOwnerState>MD</rptOwnerState><rptOwnerZipCode>21224</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle></officerTitle><otherText></otherText></reportingOwnerRelations
hip></reportingOwner><nonDerivativeTable></nonDerivativeTable><derivativeTable><derivativeTransaction><securityTitle><value>Stock Options (Right to buy)</value></securityTitle><conversionOrExercisePrice><value>6.62</value></conversionOrExercisePrice><transactionDate><value>2003-11-18</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>30000</value></transactionShares><transactionPricePerShare><value>6.62</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2004-11-18</value><footnoteId id="F1"/></exerciseDate><expirationDate><value>2013-11-18</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShar
es><value>30000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>30000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership><natureOfOwnership><value></value></natureOfOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">The options to which this note relates will vest 50% on 11/18/2004 and the remaining 50% on 11/18/2005.</footnote></footnotes><ownerSignature><signatureName>Asher M. Rubin</signatureName><signatureDate>2003-11-20</signatureDate></ownerSignature></ownershipDocument>

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</SEC-DOCUMENT>
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