-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 R3XwbKgqMwHaA/UUmbrNVDCjUj5WQ9Eg1AZ+9cnU+UBmh3ITT/KT5urEOL7iqkdE
 jyluYYVeaeYohYgEMtNG+g==

<SEC-DOCUMENT>0001239916-03-000003.txt : 20031120
<SEC-HEADER>0001239916-03-000003.hdr.sgml : 20031120
<ACCEPTANCE-DATETIME>20031120150955
ACCESSION NUMBER:		0001239916-03-000003
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031118
FILED AS OF DATE:		20031120

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			UPRICHARD DAVID C
		CENTRAL INDEX KEY:			0001239916

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23736
		FILM NUMBER:		031015418

	MAIL ADDRESS:	
		STREET 1:		12 PINE STREET
		CITY:			PHILADELPHIA
		STATE:			PA
		ZIP:			19106

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GUILFORD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000918066
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521841960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>c0001239916d20031120f3f.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>3</documentType><periodOfReport>2003-11-18</periodOfReport><noSecuritiesOwned>1</noSecuritiesOwned><issuer><issuerCik>0000918066</issuerCik><issuerName>GUILFORD PHARMACEUTICALS INC</issuerName>        <issuerTradingSymbol>GLFD</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001239916</rptOwnerCik><rptOwnerName>UPRICHARD DAVID C</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>C/O GUILFORD PHARMACUTICALS INC.</rptOwnerStreet1><rptOwnerStreet2>6611 TRIBUTARY STREET</rptOwnerStreet2><rptOwnerCity>BALTIMORE</rptOwnerCity><rptOwnerState>MD</rptOwnerState><rptOwnerZipCode>21224</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle></officerTitle><otherText></otherText></reportingOwnerRelationship></re
portingOwner><nonDerivativeTable></nonDerivativeTable><derivativeTable></derivativeTable><footnotes></footnotes><ownerSignature><signatureName>Asher M. Rubin</signatureName><signatureDate>2003-11-20</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----