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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 CuCJW/cSOxOmj+hgnVsMuIKsPjGvzY5xBhCeLbbcpS34D/H1CIuVHz/TBixeO0Ty
 YidIaN0jylKMXpYKTU7qDQ==

<SEC-DOCUMENT>0001206345-03-000002.txt : 20030618
<SEC-HEADER>0001206345-03-000002.hdr.sgml : 20030618
<ACCEPTANCE-DATETIME>20030618115408
ACCESSION NUMBER:		0001206345-03-000002
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030616
FILED AS OF DATE:		20030618

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GUILFORD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000918066
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521841960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BRENNAN JOHN P
		CENTRAL INDEX KEY:			0001206345

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23736
		FILM NUMBER:		03748322

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY STREET
		STREET 2:		C/O GUILFORD PHARMACEUTICALS INC
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300

	MAIL ADDRESS:	
		STREET 1:		C/O GUILFORD PHARMACEUTICALS INC
		STREET 2:		6611 TIBUTARY ST.
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c0001206345d20030618f4f.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType><periodOfReport>2003-06-16</periodOfReport><notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000918066</issuerCik>
        <issuerName>GUILFORD PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>GLFD</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId>
            <rptOwnerCik>0001206345</rptOwnerCik>
            <rptOwnerName>BRENNAN JOHN P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>0</isDirector><isOfficer>1</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle>SVP, Technical Operations</officerTitle><otherText></otherText></reportingOwnerRelationship></reportingOwner><nonDerivativeSecurity><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-06-16</value></transactionDate><deemedExecutionDate><value>1988-08-08</value><footnoteId id="F1"/></deemedExecutionDate><transactionCoding><transactionFormType>5</transactionFormType><transactionCode>J</transactionCode><equitySwapInvolved>0</equitySwapInvolved><footnoteId id="F2"/></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>6590</value></transactionShares><transactionValue><value>2.9</value></transactionValue><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>83809</value><f
ootnoteId id="F3"/></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership><natureOfOwnership><value></value></natureOfOwnership></ownershipNature></nonDerivativeSecurity><footnotes><footnote id="F1">SEC's dummy date being used.  No execution, exercisable or expiration date associated with this purchase.</footnote><footnote id="F2">Shares acquired under Guilford's stock purchase plan.</footnote><footnote id="F3">5,232       Indirect  By 401(k)
3,000       Indirect  By Spouse</footnote></footnotes><ownerSignature><signatureName>Asher M. Rubin</signatureName><signatureDate>2003-06-18</signatureDate></ownerSignature></ownershipDocument>

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</TEXT>
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</SEC-DOCUMENT>
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