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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 MmY9LS9g82phKsRs0JeN5ZugLCpB4h7naVEkjMUj1oNQAinszQ+3ISjONx1SFd+t
 Mtw+3l90GqeRCD0ajLu8Vw==

<SEC-DOCUMENT>0000918066-03-000012.txt : 20031223
<SEC-HEADER>0000918066-03-000012.hdr.sgml : 20031223
<ACCEPTANCE-DATETIME>20031223112954
ACCESSION NUMBER:		0000918066-03-000012
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031219
FILED AS OF DATE:		20031223

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GUILFORD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000918066
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521841960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			FOX BARRY M
		CENTRAL INDEX KEY:			0001206376

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23736
		FILM NUMBER:		031069865

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY STREET
		STREET 2:		C/O GUILFORD PHARMACEUTICALS INC
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300

	MAIL ADDRESS:	
		STREET 1:		C/O GUILFORD PHARMACEUTICALS INC
		STREET 2:		6611 TIBUTARY ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c0001206376d20031223f4s1f.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-12-19</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000918066</issuerCik><issuerName>GUILFORD PHARMACEUTICALS INC</issuerName>        <issuerTradingSymbol>GLFD</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001206376</rptOwnerCik><rptOwnerName>FOX BARRY M</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>C/O GUILFORD PHARMACUTICALS INC.</rptOwnerStreet1><rptOwnerStreet2>6611 TRIBUTARY STREET</rptOwnerStreet2><rptOwnerCity>BALTIMORE</rptOwnerCity><rptOwnerState>MD</rptOwnerState><rptOwnerZipCode>21224</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle></officerTitle><otherText></otherText></reportingOwnerRelationship></
reportingOwner><nonDerivativeTable><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-12-19</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>5</transactionFormType><transactionCode>P</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>2900</value></transactionShares><transactionPricePerShare><value>6</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>25400</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership><natureOfOwnership><value></value></natureOfOwnership></ownershipNature></nonDerivativeTransaction></no
nDerivativeTable><derivativeTable><derivativeHolding><securityTitle><value>Stock Options (Right to buy)</value></securityTitle><conversionOrExercisePrice><value>4.2</value></conversionOrExercisePrice><exerciseDate><value>2003-09-20</value></exerciseDate><expirationDate><value>2012-09-20</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>30000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>30000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership><natureOfOwnership><value></value></natureOfOwnership></ownershipNature></derivativeHolding></derivativeTable><footnotes></footnotes><ownerSignature><signatureName>Asher M. Rubin, Esq.</signatureName><signatureDate>2003-12-23</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
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</SEC-DOCUMENT>
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