-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 NWxKBVydugO31Ns5qFUr8g==

<SEC-DOCUMENT>0000902664-03-001586.txt : 20031030
<SEC-HEADER>0000902664-03-001586.hdr.sgml : 20031030
<ACCEPTANCE-DATETIME>20031030200954
ACCESSION NUMBER:		0000902664-03-001586
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20021204
FILED AS OF DATE:		20031030

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GUILFORD PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000918066
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521841960
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6611 TRIBUTARY ST
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21224
		BUSINESS PHONE:		4106316300

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DURUS LIFE SCIENCES MASTER FUND LTD
		CENTRAL INDEX KEY:			0001257242

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23736
		FILM NUMBER:		03968006

	BUSINESS ADDRESS:	
		STREET 1:		20 MARSHALL ST STE 320
		CITY:			SOUTH NORWALK
		STATE:			CT
		ZIP:			06854
		BUSINESS PHONE:		2038993100
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>srzdurusglfd2_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<!-- - EDGAR Ease Plus 1.0                                   07/25/03  TT    -->
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>
   <periodOfReport>2002-12-04</periodOfReport>
   <notSubjectToSection16>1</notSubjectToSection16>
    <issuer>
        <issuerCik>0000918066</issuerCik>
        <issuerName>GUILFORD PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>GLFD</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001257242</rptOwnerCik>
            <rptOwnerName>DURUS LIFE SCIENCES MASTER FUND LTD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INT'L FUND SERVICES (IRELAND) LTD.</rptOwnerStreet1>
            <rptOwnerStreet2>3RD FL., BISHOPS SQUARE, REDMONDS HILL</rptOwnerStreet2>
            <rptOwnerCity>DUBLIN 2, IRELAND</rptOwnerCity>
            <rptOwnerState></rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>0</isDirector>
         <isOfficer>0</isOfficer>
         <isTenPercentOwner>1</isTenPercentOwner>
         <isOther>0</isOther>
      </reportingOwnerRelationship>
   </reportingOwner>
 <nonDerivativeTable>
   <nonDerivativeTransaction>
      <securityTitle>
         <value>Common Stock</value>
      </securityTitle>
      <transactionDate>
         <value>2002-12-04</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>S</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
      </transactionCoding>
      <transactionAmounts>
         <transactionShares>
           <value>27500</value>
         </transactionShares>
         <transactionPricePerShare>
           <value>3.8804</value>
         </transactionPricePerShare>
         <transactionAcquiredDisposedCode>
           <value>D</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <postTransactionAmounts>
         <sharesOwnedFollowingTransaction>
           <value>2982671</value>
         </sharesOwnedFollowingTransaction>
      </postTransactionAmounts>
      <ownershipNature>
         <directOrIndirectOwnership>
            <value>D</value>
         </directOrIndirectOwnership>
      </ownershipNature>
   </nonDerivativeTransaction>
 </nonDerivativeTable>
   <remarks>This Form 4 is being filed by Durus Life Sciences Master Fund Limited (the &quot;Master Fund&quot;) to report transactions that have already been reported on Forms 4 filed August 22, 2003 by Durus Capital Management, LLC, the Master Fund's Portfolio Manager, and Scott Sacane, the principal thereof. No new transactions are reported herein. The information on this form has been provided by International Funds Services (Ireland) Limited, the Master Fund's administrator.

Pursuant to Instruction 5(a) of Form 4, the prices herein do not include commissions and other  costs of execution.</remarks>
   <ownerSignature>
      <signatureName>DURUS LIFE SCIENCES MASTER FUND LTD. By: Leslie L. Lake, Director</signatureName>
      <signatureDate>2003-10-30</signatureDate>
   </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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