SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                  Schedule 13G


                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*


                          GUILFORD PHARMACEUTICALS INC.
                     ---------------------------------------
                                (Name of Issuer)


                                  Common Stock
                     ---------------------------------------
                         (Title of Class of Securities)


                                    401829106
                     ---------------------------------------
                                 (CUSIP Number)


Check the following box if a fee is being paid with this  statement [ ] . (A fee
is not required only if the filing person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7.)

 *The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).






CUSIP NO. 401829 10 6            13G                         Page 2 of 4 Pages



         1  Name of Reporting Person
            S.S. or I.R.S. Identification No. of Above Person

            SCIOS INC. (formerly Scios Nova Inc.)
            95-3701481

         2 Check the Appropriate Box if a Member of a Group*

         NOT APPLICABLE          (a) ____
                                 (b) ____

         3  SEC Use Only

             ------------------------------

         4  Citizenship or Place of Organization

              DELAWARE

          Number of         5  Sole Voting Power
          Shares                     1,437,500
          Beneficially      6  Shared Voting Power
          Owned By Each              -0-
          Reporting         7  Sole Dispositive Power
          Person                     1,437,500
          With              8  Shared Dispositive Power
                                     -0-

          9  Aggregate Amount Beneficially Owned by Each Reporting Person
             1,437,500

          10 Check Box if the Aggregate Amount in Row (9) Excludes Certain
             Shares*

             NOT APPLICABLE

          11 Percent of Class Represented by Amount in Row 9
             7.4%

          12 Type of Reporting Person*
             CO

                   *SEE INSTRUCTION BEFORE FILLING OUT





CUSIP NO. 401829106                13G                        Page 3 of 4 Pages


Item 1(a).  Name of Issuer
Guilford Pharmaceuticals Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices
6611 Tributary Street
Baltimore, MD  21224

Item 2(a).  Name of Person Filing
Scios Inc. (formerly Scios Nova Inc.)

Item 2(b).  Address of Principal Business Office
2450 Bayshore Parkway
Mountain View, CA 94043

Item 2(c).  Citizenship
Delaware

Item 2(d).  Title of Class of Securities
Common Stock

Item 2(e).  CUSIP No.
401829 10 6

Item 3.  If This Statement Is Filed Pursuant to Rules 13d-1(b) or 13d-2(b)
Not applicable

Item 4.  Ownership
 (a) Amount Beneficially Owned:
         1,437,500
 (b) Percent of Class:
         7.4%
 (c) Number of shares as to which such person has:
         (i)   sole power to vote or to direct the vote: 1,437,500
         (ii)  shared power to vote or to direct the vote: None
         (iii)  sole power to dispose or to direct the disposition of: 1,437,500
         (iv)  shared power to dispose or to direct the disposition of: None

Item 5.  Ownership of Five Percent or Less of a Class
Not applicable

Item 6.  Ownership of More Than Five Percent on Behalf of Another Person
Not applicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired the 
Security Being Reported on by the Parent Holding Company
Not applicable





CUSIP NO. 401829106               13G                         Page 4 of 4 Pages



Item 8.  Identification and Classification of Members of the Group
Not applicable

Item 9.  Notice of Dissolution of Group
Not applicable

Item 10.  Certification
Not applicable



                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Date:    January 27, 1998


SCIOS INC.


By:   /s/ John H. Newman
         John H. Newman
         Vice President of Legal Affairs,
         General Counsel and Secretary