CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenue
Revenue	$ 242,747	$ 224,027	$ 231,201
Cost of revenue
Cost of product revenue	37,749	27,156	18,299
Cost of contract and other revenue	5,647	9,905	11,718
Amortization of acquired intangible assets, cost of revenue	17,352	14,314	23,684
Cost of revenue	60,748	51,375	53,701
Gross Profit	181,999	172,652	177,500
Operating expenses
Research and development	139,837	156,815	158,339
Selling, General and Administrative Expense	85,619	101,373	98,254
Amortization of acquired intangible assets, operating expenses	1,061	2,743	5,657
Restructuring and other charges	4,089	8,821	2,217
Loss on divestiture	0	7,439	0
Change in fair value of earn-out liability	(1,800)	0	0
Operating Expenses, Total	228,806	277,191	264,467
Operating loss	(46,807)	(104,539)	(86,967)
Interest income and other income (expense), net	17,516	27,375	32,621
Interest expense	(10,340)	(9,852)	(16,282)
Interest and other income (expense), net	7,176	17,523	16,339
Loss before income taxes	(39,631)	(87,016)	(70,628)
Provision for income taxes	3,978	3,403	87,329
Net loss	$ (43,609)	$ (90,419)	$ (157,957)
Net loss per share:
Basic (in dollars per share)	$ (0.39)	$ (0.81)	$ (1.46)
Diluted (in dollars per share)	$ (0.39)	$ (0.81)	$ (1.46)
Weighted-average shares used in per share calculations:
Basic (in shares)	113,254	110,948	108,450
Diluted (in shares)	113,254	110,948	108,450
Royalties
Revenue
Revenue	$ 80,985	$ 90,785	$ 130,452
Product revenue
Revenue
Revenue	113,996	72,972	38,690
Contract and other revenue
Revenue
Revenue	$ 47,766	$ 60,270	$ 62,059