Condensed Consolidated Statements of Operations And Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Revenues	$ 138,403	$ 71,086
Operating expenses:
Cost of sales	1,129	950
Research and development	37,652	48,947
Acquired in-process research and development	113,081
Selling, general and administrative	87,538	58,636
Total operating expenses	239,400	108,533
Operating loss	(100,997)	(37,447)
Other (expense) income:
Interest expense	(7,853)	(7,504)
Unrealized gain on investment in restricted equity securities	1,680
Investment income and other, net	4,576	3,133
Total other expense, net	(1,597)	(4,371)
Loss before benefit from income taxes	(102,594)	(41,818)
Benefit from income taxes	(479)
Net loss	(102,115)	(41,818)
Unrealized gain (loss) on available-for-sale securities, net of tax	1,699	(1,847)
Comprehensive loss	$ (100,416)	$ (43,665)
Net loss per share, basic and diluted	$ (1.12)	$ (0.47)
Weighted average common shares outstanding, basic and diluted	91,056	89,526
Product sales, net
Revenues:
Revenues	$ 136,431	$ 71,086
Collaboration revenue
Revenues:
Revenues	$ 1,972