Condensed Consolidated Statements of Operations And Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Product sales, net	$ 96,905	$ 6,335	$ 167,991	$ 6,335
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Total revenues	$ 96,905	$ 6,335	$ 167,991	$ 6,335
Operating expenses:
Cost of product sales	$ 854	$ 61	$ 1,804	$ 61
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Research and development	$ 36,988	$ 21,868	$ 85,935	$ 73,750
Sales, general and administrative	60,915	41,674	119,551	69,724
Total operating expenses	98,757	63,603	207,290	143,535
Loss from operations	(1,852)	(57,268)	(39,299)	(137,200)
Other (expense) income:
Deferred gain on real estate	183	879	366	1,758
Interest expense	(7,591)	(4,767)	(15,095)	(4,767)
Investment income and other, net	3,347	1,171	6,297	1,898
Total other expense, net	(4,061)	(2,717)	(8,432)	(1,111)
Net loss	$ (5,913)	$ (59,985)	$ (47,731)	$ (138,311)
Net loss per common share:
Basic and diluted	$ (0.07)	$ (0.68)	$ (0.53)	$ (1.58)
Shares used in the calculation of net loss per common share:
Basic and diluted	90,100	88,063	89,814	87,675
Other comprehensive loss:
Net loss	$ (5,913)	$ (59,985)	$ (47,731)	$ (138,311)
Net unrealized gain (loss) on available-for-sale securities	888	(478)	(959)	(395)
Comprehensive loss	$ (5,025)	$ (60,463)	$ (48,690)	$ (138,706)