Commitments and Contingencies - Additional Information (Detail)	1 Months Ended	12 Months Ended
	Dec. 31, 2007 USD ($) Building	Dec. 31, 2015 USD ($) ft² RenewalOptions Lease_Agreements	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2008 USD ($)
Commitment And Contingencies [Line Items]
Sale of facility and associated real property	$ 109,000,000
Mortgage debt retired	47,700,000
Cash received net of transaction costs and debt retirement	$ 61,000,000
Leaseback transaction lease period	12 years
Number of building leased | Building	2
Net deferred gain on real estate sale		$ 14,300,000			$ 39,100,000
Deferred gain recognized on real estate sale		$ 3,300,000	$ 3,200,000	$ 3,100,000
Lease expiration year		2019
Percentage of management fee included in the base annual rent		3.50%
Letter of credit		$ 4,600,000
Lease extension period		10 years
Number of times to renew the lease contract | RenewalOptions		2
Subleased area | ft²		30,000
Rental income from sublease agreement		$ 1,100,000
Rent expense		$ 5,900,000	$ 5,900,000	$ 5,900,000
Lease period		12 years
Lease expiration year		2019
Cash and investment required to be maintained		$ 50,000,000
Security deposit to be increased		5,000,000
Milestone payables		$ 17,000,000
Minimum
Commitment And Contingencies [Line Items]
Lease cancellation, notice period		0 days
Maximum
Commitment And Contingencies [Line Items]
Lease cancellation, notice period		180 days
Royalty, rate		5.00%
Sublease
Commitment And Contingencies [Line Items]
Number of sublease agreements | Lease_Agreements		2
Lease renewal additional periods		1 year
Lease expiration date		2017-02
Second Sublease
Commitment And Contingencies [Line Items]
Lease renewal additional periods		1 year
Lease expiration date		2018-03