Note 7 - Share-based Compensation - Summary of Stock Option Activity (Details) - Employee and Nonemployee Stock Option [Member] - USD ($) $ / shares in Units, $ in Thousands	9 Months Ended
Sep. 30, 2022
Outstanding, shares under options (in shares)	98,671
Outstanding, weighted average exercise price (in dollars per share)	$ 33.53
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares)	9,876
Granted (in dollars per share)	$ 77.28
Exercised, shares under options (in shares)	(15,245)
Granted, weighted average exercise price (in dollars per share)	$ 24.10
Outstanding, shares under options (in shares)	93,302
Outstanding, weighted average exercise price (in dollars per share)	$ 39.70
Outstanding, weighted average remaining contractual life (Year)	6 years 1 month 17 days
Outstanding, aggregate intrinsic value	$ 4,305
Exercisable, shares under options (in shares)	83,426
Exercisable, weighted average exercise price (in dollars per share)	$ 35.26
Exercisable, weighted average remaining contractual life (Year)	5 years 8 months 15 days
Exercisable, aggregate intrinsic value	$ 4,220
Vested and expected to vest, shares under options (in shares)	93,302
Vested and expected to vest, weighted average exercise price (in dollars per share)	$ 39.70
Vested and expected to vest, weighted average remaining contractual life (Year)	6 years 1 month 17 days
Vested and expected to vest, aggregate intrinsic value	$ 4,305

The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest exercisable or convertible options. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of share options (or share units) exercised during the current period.

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