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Note 12 - Income Taxes and Tax Status (Tables)
12 Months Ended
Dec. 31, 2022
Notes Tables  
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
   

2022

   

2021

 

Tax benefit at statutory rate

  $ (2,061 )   $ (2,589 )

State tax benefit

    (422 )     (530 )

Increase in valuation allowance

    2,416       3,368  

Other

    67       (249 )
    $ -     $ -  
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
   

2022

   

2021

 

Gross deferred tax assets:

               

Net operating loss carry-forward

  $ 75,470     $ 78,600  

Research and development credit carry-forward

    5,356       6,028  

Stock compensation

    1,127       356  

Patents and other

    1,482       1,470  

Contingent payment obligations

    7,033       6,341  

Fixed assets

    (2 )     53  

Lease liabilities

    1       38  
      90,467       92,886  

Less valuation allowance

    (90,467 )     (92,886 )
      -       -  

Gross deferred tax liabilities:

               

Convertible debt

    -       -  
      -       -  

Net deferred tax asset

  $ -     $ -  
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
   

2022

   

2021

 

Unrecognized tax benefits – beginning of year

  $ 653     $ 927  

Reduction as a result of lapse of statute of limitations

    (15 )     (274 )

Unrecognized tax benefits – end of year

  $ 638     $ 653