AUTHORIZATION LETTER

December 13, 2006

Securities and Exchange Commission
450 Fifth Street, NW
Washington, D.C. 20549
Attn:  Filing Desk

To whom it may concern:

By means of this letter I authorize Kathy A. San Roman to sign on my behalf
all forms required under Section 16(a) of the Securities Exchange
Act of 1934, as amended, relating to transactions involving the
stock or derivative securities of Solexa, Inc. (the "Company").  Any
of these individuals is accordingly authorized to sign any Form 3,
Form 4, Form 5 or amendment therto which I am required to file
with the same effect as if I had signed them myself.

This authorization shall remain in effect until revoked in writing by
me.

Yours truly,
/s/ Linda Rubinstein
Linda Rubinstein

POWER OF ATTORNEY

Know all by these present, that the undersigned hereby constitutes
and appoints Kathy A. San Roman, signing individually, the undersigned's
 true and lawful attorneys-in-fact and agents to:

1) execute for and on behalf of the undersigned, an officer, director
or holder of 10% of more of a registered class of securities of Solexa,
Inc.  ("Solexa"), Forms 3, 4 and 5 in accordance with Section 16(a) of
the Securities Exchange Act of 1934, as amended (the"Exchange
Act") and the rules thereunder;

2)do and perform any an all acts for and on behalf of the undersigned
that may be necessary or desirable to complete and execute such
Form 3, 4 or 5, complete and execute any amendment or amendments
thereto, and timely file such forms or amendments with the United
States Securities and Exchange Commission and any stock exchange
or similar authority; and

3)take any other action of any nature whatsoever in connection with
the foregoing which, in the opinion of such attorney-in-fact, may
be of benefit, in the best interest of, or legally required by, the
undersigned, it being understood that the documents executed
by such attorney-in-fact on behalf of the undersigned pursuant
to thie Power of Attorney shall be in such form and shall contain
such terms and conditions as such attorney-in-fact may approve
in such attorney-in-fact's discretion.

The undersigned hereby grants  such attorney-in-fact
full power and authority to do and perform any and every act
and thing whatsoever requisite, necessary, or proper to be
done in the exercise of any of the rights and powers herein
granted, as fully to all intents and purposes as the undersigned
might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming
all that such attorney-in-fact, or such attorney-in-fact's
substitute or substitutes, shall lawfully do or cause to be
done by viture of this power of attorney and the rights and
powers herein granted.  The undersigned acknowledges that
the foregoing attorney-in-fact, in serving in such capacity
 at the request of the undersigned, is not assuming, nor is
Solexa assuming, any of the undersigned's responsibilities
to comply with Section 16 of the Exchange Act.

This Power of Attorney shall remain in full force and effect
until the arliest to occur of a)the undersigned is no longer
requuired to file Forms 3, 4 and 5 with respect to the
undersigned's holdings of and transactions in securities
issued by Solexa, b)revocation by the undersigned in a
signed writing delivered to the foregoing attorney-in-
fact or c)as to any attorney-in-fact individually, until
such attorney-in-fact shall no longer be employed by
Solexa.

IN WITNESS WHEREOF, the undersigned has caused this
Power of Attorney to be executed as of this 13th day
of December, 2006.

/s/Linda Rubinstein
Linda Rubinstein