UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K/A

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 17, 2004

AFFYMETRIX, INC.

(Exact name of registrant as specified in its charter)

DELAWARE		0-28218		77-0319159
(State of incorporation)		(Commission File Number)		(IRS Employer Identification No.)

3420 Central Expressway
Santa Clara, California 95051

(Address of principal executive offices) (Zip Code)

(408) 731-5000

Registrant’s telephone number, including area code

N/A

(Former name or former address, if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 5.02 Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.

This filing supplements Item 5.02 of the Current Report on Form 8-K of Affymetrix, Inc. (the “Company”), filed on November 23, 2004. In that filing, the Company reported that its Board of Directors (the “Board”) had elected Susan Desmond-Hellmann, M.D. as a director.

The Board appointed Susan Desmond-Hellmann, M.D. to serve as a member of the Compensation Committee of the Board effective as of February 15, 2006.

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	AFFYMETRIX, INC.


	By:	/s/ Barbara A. Caulfield
		Name: Barbara A. Caulfield
		Title: Executive Vice President and General Counsel

Dated: February 16, 2006