8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): February 16, 2011

AFFYMETRIX, INC.

(Exact name of registrant as specified in its charter)

DELAWARE	0-28218	77-0319159
(State of incorporation)	(Commission File Number)	(IRS Employer Identification No.)

3420 Central Expressway

Santa Clara, California 95051

(Address of principal executive offices) (Zip Code)

(408) 731-5000

Registrant’s telephone number, including area code

(Former name or former address, if changed since last report.)

                                                                                                                                              0;        

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

o             Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o             Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o             Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o             Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 5.02   Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On February 22, 2011, Affymetrix announced that Paul Berg, Ph.D. will retire from the Board of Directors of Affymetrix in May 2011, after completing his term.  The full text of the press release is attached to this Current Report on Form 8-K as Exhibit 99.1

Item 9.01   Financial Statements and Exhibits

(d)     Exhibits.

Exhibit No.	Description
99.1	Press Release, issued by Affymetrix, Inc. on February 22, 2011

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.

AFFYMETRIX, INC.
By:	/s/ JOHN F. RUNKEL, JR.
	Name:	John F. Runkel, Jr.
	Title:	Executive Vice President, General Counsel and Secretary

Dated: February 22, 2011

EXHIBIT INDEX

Exhibit No.	Description
99.1	Press Release dated February 22, 2011

EX-99.1

Affymetrix Director Paul Berg to Retire

SANTA CLARA, Calif., Feb 22, 2011 (BUSINESS WIRE) – Affymetrix, Inc. (NASDAQ: AFFX) today announced that Paul Berg, Ph.D. and Nobel Laureate will retire from the Affymetrix Board of Directors in May 2011.  Dr. Berg has been a board member of the company since its inception in 1993.

“On behalf of the Board of Directors and all of us at Affymetrix, I thank Paul for his 19 years of vision, leadership and insights to the science, technologies and directions of our industry,” said Stephen P.A. Fodor, Ph.D., founder and chairman of Affymetrix.  “Paul’s inspiration helped shape the scientific foundations of the company and will endure long into the future. We wish him well in his retirement.”

About Affymetrix

Affymetrix technology is used by the world’s top pharmaceutical, diagnostic, and biotechnology companies, as well as leading academic, government and nonprofit research institutes.  More than 2,000 systems have been shipped around the world and approximately 23,000 peer-reviewed papers have been published using the technology.

Affymetrix is headquartered in Santa Clara, Calif., and has manufacturing facilities in Santa Clara, Cleveland, Ohio, and Singapore.  The company has about 900 employees worldwide and maintains sales and distribution operations across Europe and Asia.  For more information about Affymetrix, please visit the company’s website at http://www.affymetrix.com.

Forward-looking statements

All statements in this press release that are not historical are “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act as amended, including statements regarding Affymetrix’ “expectations,” “beliefs,” “hopes,” “intentions,” “strategies,” or the like.  Such statements are subject to risks and uncertainties that could cause actual results to differ materially for Affymetrix from those projected.  These and other risk factors are discussed in Affymetrix’ Annual Report on Form 10-K for the year ended December 31, 2009, and other SEC reports for subsequent quarterly periods.

Affymetrix, and the Affymetrix logo are registered trademarks of Affymetrix, Inc.  All other trademarks are property of their respective owners.

SOURCE:  Affymetrix, Inc.

Affymetrix, Inc.

Investor Contact:

Doug Farrell, 408-731-5285

Vice President, Investor Relations