Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Revenue:
Royalty revenue	$ 927	$ 1,447
Collaboration and license revenue		139
Total revenue	927	1,586
Costs and expenses:
Research and development	38,207	27,868
Selling, general and administrative	21,671	9,804
Amortization of developed technology	222	390
Total costs and expenses	60,100	38,062
Loss from operations	(59,173)	(36,476)
Other expense, net	(252)	(5)
Interest income, net	83	75
Loss before provision for income taxes	(59,342)	(36,406)
Provision for income taxes	259	18
Net loss	$ (59,601)	$ (36,424)
Basic and diluted net loss per common share	$ (1.63)	$ (1.16)
Weighted average shares used in basic and diluted per common share computations	36,495	31,338