SC 13G

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No.     )*

Synageva BioPharma Corp.

(Name of Issuer)

Common Stock, $0.001 par value per share

(Title of Class of Securities)

87159A 103

(CUSIP Number)

December 31, 2011

(Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)

x Rule 13d-1(c)

¨ Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13G

CUSIP No. 87159A 103 Page 2 of 13

1	NAMES OF REPORTING PERSONS James L.L. Tullis
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a)  ¨        (b)  ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION     United States
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER*     0
		6	SHARED VOTING POWER     1,582,974
		7	SOLE DISPOSITIVE POWER     0
		8	SHARED DISPOSITIVE POWER     1,582,974
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON     1,582,974
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)  ¨
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**     7.5 %
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)     IN

SCHEDULE 13G

CUSIP No. 87159A 103 Page 3 of 13

1	NAMES OF REPORTING PERSONS Tullis-Dickerson Capital Focus II, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a)  ¨        (b)  ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION     Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER*     0
		6	SHARED VOTING POWER     382,407
		7	SOLE DISPOSITIVE POWER     0
		8	SHARED DISPOSITIVE POWER     382,407
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON     382,407
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)  ¨
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**     1.8%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)     PN

SCHEDULE 13G

CUSIP No. 87159A 103 Page 4 of 13

1	NAMES OF REPORTING PERSONS Tullis-Dickerson Partners II, L.L.C.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a)  ¨        (b)  ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION     Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER*     0
		6	SHARED VOTING POWER     382,407
		7	SOLE DISPOSITIVE POWER     0
		8	SHARED DISPOSITIVE POWER     382,407
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON     382,407
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)  ¨
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**     1.8%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)     PN

SCHEDULE 13G

CUSIP No. 87159A 103 Page 5 of 13

1	NAMES OF REPORTING PERSONS TD Javelin Capital Fund II, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a)  ¨        (b)  ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION     Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER*     0
		6	SHARED VOTING POWER     638,358
		7	SOLE DISPOSITIVE POWER     0
		8	SHARED DISPOSITIVE POWER     638,358
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON     638,358
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)  ¨
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**     3.0%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)     PN

SCHEDULE 13G

CUSIP No. 87159A 103 Page 6 of 13

1	NAMES OF REPORTING PERSONS TD Lighthouse Capital Fund, L.P.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a)  ¨        (b)  ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION     Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER*     0
		6	SHARED VOTING POWER     562,209
		7	SOLE DISPOSITIVE POWER     0
		8	SHARED DISPOSITIVE POWER     562,209
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON     562,209
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)  ¨
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**     2.7%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)     PN

SCHEDULE 13G

CUSIP No. 87159A 103 Page 7 of 13

1	NAMES OF REPORTING PERSONS TD II Regional Partners, Inc.
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a)  ¨        (b)  ¨
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION     Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER*     0
		6	SHARED VOTING POWER     1,200,567
		7	SOLE DISPOSITIVE POWER     0
		8	SHARED DISPOSITIVE POWER     1,200,567
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON     1,200,567
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)  ¨
11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9**     5.7%
12	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)     PN

SCHEDULE 13G

CUSIP No. 87159A 103 Page 8 of 13

Item 1	(a)	Name of Issuer:
		Synageva BioPharma Corp.
Item 1	(b)	Address of Issuer’s Principal Executive Offices:
		128 Spring Street, Suite 520 Lexington, Massachusetts 02421
Item 2	(a)	Name of Person Filing:
		James L.L. Tullis Tullis-Dickerson Capital Focus II, L.P. Tullis-Dickerson Partners II, L.L.C. TD Javelin Capital Fund II, L.P. TD Lighthouse Capital Fund, L.P. TD II Regional Partners, Inc.
Item 2	(b)	Address of Principal Business Office or, if none, Residence:
		The address of the principal business office of each of the Reporting Persons is One Stamford Plaza, 263 Tresser Boulevard, Stamford, CT 06901.
Item 2	(c)	Citizenship:
		James L.L. Tullis – United States Tullis-Dickerson Capital Focus II, L.P. – Delaware Tullis-Dickerson Partners II, L.L.C. – Delaware TD Javelin Capital Fund II, L.P. – Delaware TD Lighthouse Capital Fund, L.P. – Delaware TD II Regional Partners, Inc. – Delaware
Item 2	(d)	Title of Class of Securities:
		Common Stock, $0.001 par value per share
Item 2	(e)	CUSIP Number:
		87159A 103
Item 3		Not applicable.
Item 4		Ownership.
		Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

SCHEDULE 13G

CUSIP No. 87159A 103 Page 9 of 13

(a)	Amount beneficially owned:
	James L.L. Tullis – 1,582,974 Tullis-Dickerson Capital Focus II, L.P. – 382,407 Tullis-Dickerson Partners II, L.L.C. – 382,407 TD Javelin Capital Fund II, L.P. – 638,358 TD Lighthouse Capital Fund, L.P. – 562,209 TD II Regional Partners, Inc. – 1,200,567
(b)	Percent of class:
	James L.L. Tullis – 7.5% Tullis-Dickerson Capital Focus II, L.P. – 1.8% Tullis-Dickerson Partners II, L.L.C. – 1.8% TD Javelin Capital Fund II, L.P. – 3.0% TD Lighthouse Capital Fund, L.P. – 2.7% TD II Regional Partners, Inc. – 5.7%
(c)	Number of shares as to which the person has:
	(i)	Sole power to vote or to direct the vote
		James L.L. Tullis – 0 Tullis-Dickerson Capital Focus II, L.P. – 0 Tullis-Dickerson Partners II, L.L.C. – 0 TD Javelin Capital Fund II, L.P. – 0 TD Lighthouse Capital Fund, L.P. – 0 TD II Regional Partners, Inc. – 0
	(ii)	Shared power to vote or to direct the vote
		James L.L. Tullis – 1,582,974 Tullis-Dickerson Capital Focus II, L.P. – 382,407 Tullis-Dickerson Partners II, L.L.C. – 382,407 TD Javelin Capital Fund II, L.P. – 638,358 TD Lighthouse Capital Fund, L.P. – 562,209 TD II Regional Partners, Inc. – 1,200,567
	(iii)	Sole power to dispose or to direct the disposition of
		James L.L. Tullis – 0 Tullis-Dickerson Capital Focus II, L.P. – 0 Tullis-Dickerson Partners II, L.L.C. – 0 TD Javelin Capital Fund II, L.P. – 0 TD Lighthouse Capital Fund, L.P. – 0 TD II Regional Partners, Inc. – 0
	(iv)	Shared power to dispose or to direct the disposition of

SCHEDULE 13G

CUSIP No. 87159A 103 Page 10 of 13

		James L.L. Tullis – 1,582,974 Tullis-Dickerson Capital Focus II, L.P. – 382,407 Tullis-Dickerson Partners II, L.L.C. – 382,407 TD Javelin Capital Fund II, L.P. – 638,358 TD Lighthouse Capital Fund, L.P. – 562,209 TD II Regional Partners, Inc. – 1,200,567
	As the general partner of Tullis-Dickerson Capital Focus II, L.P., Tullis-Dickerson Partners II, L.L.C. is deemed to beneficially own 382,407 shares of the Issuer’s common stock. As the general partner of each of TD Javelin Capital Fund II, L.P. and TD Lighthouse Capital Fund, L.P., TD II Regional Partners, Inc. is deemed to beneficially own 1,200,567 shares of the Issuer’s common stock. As the sole Manager of Tullis-Dickerson Partners II, L.L.C. and the Chief Executive Officer and sole director of TD II Regional Partners, Inc., James L.L. Tullis is deemed to beneficially own 1,582,974 shares of the Issuer’s common stock. All share numbers and ownership percentages reported herein are as of January 31, 2012, and are calculated based on 21,155,956 outstanding shares of the Issuer’s common stock as of January 10, 2012.
Item 5	Ownership of Five Percent or Less of a Class.
	If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following  ¨.
Item 6	Ownership of More than Five Percent on Behalf of Another Person.
	Not applicable.
Item 7	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not applicable.
Item 8	Identification and Classification of Members of the Group.
	The Reporting Persons are parties to a Joint Filing Agreement filed herewith as Exhibit 99.1.
Item 9	Notice of Dissolution of Group.

SCHEDULE 13G

CUSIP No. 87159A 103 Page 11 of 13

	Not applicable.
Item 10	Certification.
	By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

SCHEDULE 13G

CUSIP No. 87159A 103 Page 12 of 13

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 1, 2012	JAMES L.L. TULLIS
	/s/ James L. L. Tullis
	Name: James L. L. Tullis
	TULLIS-DICKERSON CAPITAL FOCUS II, L.P.
	By: Tullis-Dickerson Partners II, L.L.C., its general partner
	/s/ James L. L. Tullis
	Name: James L. L. Tullis
	Title: Manager
	TULLIS-DICKERSON PARTNERS II, L.L.C.
	/s/ James L. L. Tullis
	Name: James L. L. Tullis
	Title: Manager
	TD LIGHTHOUSE CAPITAL FUND, L.P.
	By: TD II Regional Partners, Inc., its general partner
	/s/ James L. L. Tullis
	Name: James L. L. Tullis
	Title: Chief Executive Officer
	TD JAVELIN CAPITAL FUND II, L.P.
	By: TD II Regional Partners, Inc., its general partner
	/s/ James L. L. Tullis
	Name: James L. L. Tullis
	Title: Chief Executive Officer
	TD II REGIONAL PARTNERS, INC.
	/s/ James L. L. Tullis
	Name: James L. L. Tullis
	Title: Chief Executive Officer

SCHEDULE 13G

CUSIP No. 87159A 103 Page 13 of 13

EXHIBIT INDEX

Exhibit No.
99.1	Joint Filing Agreement pursuant to Rule 13d-1(k)(1) among James L.L. Tullis, Tullis-Dickerson Capital Focus II, L.P., Tullis-Dickerson Partners II, L.L.C., TD Javelin Capital Fund II, L.P., TD Lighthouse Capital Fund, L.P. and TD II Regional Partners, Inc.

EX-99.1

SCHEDULE 13G

CUSIP No. 87159A 103

Exhibit 99.1

JOINT FILING AGREEMENT

Joint Filing Agreement, dated as of February 1, 2012, is by and among James L.L. Tullis, Tullis-Dickerson Capital Focus II, L.P., Tullis-Dickerson Partners II, L.L.C., TD Lighthouse Capital Fund, L.P., TD Javelin Capital Fund II, L.P. and TD II Regional Partners, Inc. (the “TD Filers”).

Each of the TD Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13G with respect to shares of Common Stock, par value $0.001 per share, of Synageva BioPharma Corp. beneficially owned by it from time to time. Pursuant to and in accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, each of the TD Filers hereby agree to be responsible for the timely filing of the Schedule 13G and any amendments thereto on behalf of the TD Filers, and for the completeness and accuracy of the information concerning itself contained therein. Each of the TD Filers hereby further agree to file this Joint Filing Agreement as an exhibit to the statement and each such amendment, as required by such rule.

This Joint Filing Agreement may be terminated by any of the TD Filers upon one week’s prior written notice or such lesser period of notice as the TD Filers may mutually agree.

Executed and delivered as of the date first above written.

JAMES L.L. TULLIS

/s/ James L. L. Tullis

Name: James L. L. Tullis

TULLIS-DICKERSON CAPITAL FOCUS II, L.P.

By: Tullis-Dickerson Partners II, L.L.C., its general partner

/s/ James L. L. Tullis

Name: James L. L. Tullis

Title: Manager

SCHEDULE 13G

CUSIP No. 87159A 103

TULLIS-DICKERSON PARTNERS II, L.L.C.

/s/ James L. L. Tullis

Name: James L. L. Tullis

Title: Manager

TD LIGHTHOUSE CAPITAL FUND, L.P.

By: TD II Regional Partners, Inc., its general partner

/s/ James L. L. Tullis

Name: James L. L. Tullis

Title: Chief Executive Officer

TD JAVELIN CAPITAL FUND II, L.P.

By: TD II Regional Partners, Inc., its general partner

/s/ James L. L. Tullis

Name: James L. L. Tullis

Title: Chief Executive Officer

TD II REGIONAL PARTNERS, INC.

/s/ James L. L. Tullis

Name: James L. L. Tullis

Title: Chief Executive Officer