Exhibit 23

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Board of Directors and Stockholders

Trimeris, Inc.:

We consent to the incorporation by reference in the Registration Statements (No. 333-44145, No. 333-44147, No. 333-64064, No. 333-66401, No. 333-74304, No. 333-90377 and No. 333-107508) on Forms S-8 and the Registration Satements (No. 333-31662, No. 333-60724, No. 333-76689, No. 333-81708 and No. 333-98587) on Forms S-3 of Trimeris, Inc. of our reports dated March 9, 2005, with respect to the balance sheets of Trimeris, Inc. as of December 31, 2004 and 2003, and the related statements of operations, stockholders’ equity, and cash flows for each of the years in the three-year period ended December 31, 2004, and mangagement’s assessment of the effectiveness of internal control over financial reporting as of December 31, 2004 and the effectiveness of internal control over financial reporting as of December 31, 2004, which reports appear in the December 31, 2004, annual report on Form 10-K of Trimeris, Inc.

/s/ KPMG LLP

Raleigh, North Carolina

March 9, 2005