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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PTaT89D3oU0a76YhPXIrxb0Muz4WElyBobsuRaZihtfmLSocbULjiyD96fyNclkN
 o/FbJxTp9gDKWMbCuwScpg==

<SEC-DOCUMENT>0001181431-10-057637.txt : 20101124
<SEC-HEADER>0001181431-10-057637.hdr.sgml : 20101124
<ACCEPTANCE-DATETIME>20101124171727
ACCESSION NUMBER:		0001181431-10-057637
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101123
FILED AS OF DATE:		20101124
DATE AS OF CHANGE:		20101124

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Thomas James R
		CENTRAL INDEX KEY:			0001469932

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23155
		FILM NUMBER:		101215677

	MAIL ADDRESS:	
		STREET 1:		2530 MERIDIAN PARKWAY
		STREET 2:		2ND FLOOR
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27713

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TRIMERIS INC
		CENTRAL INDEX KEY:			0000911326
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				561808663
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2530 MERIDIAN PARKWAY
		STREET 2:		2ND FLOOR
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27713
		BUSINESS PHONE:		(919) 806-4682

	MAIL ADDRESS:	
		STREET 1:		2530 MERIDIAN PARKWAY
		STREET 2:		2ND FLOOR
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27713
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd292209.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-11-23</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000911326</issuerCik>
        <issuerName>TRIMERIS INC</issuerName>
        <issuerTradingSymbol>TRMS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001469932</rptOwnerCik>
            <rptOwnerName>Thomas James R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2530 MERIDIAN PARKWAY</rptOwnerStreet1>
            <rptOwnerStreet2>2ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>DURHAM</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27713</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Incentive Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.51</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-11-23</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2011-11-18</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2020-11-23</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>135000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">25% on 11/18/11; additional 2.0833% on the same day in each subsequent month until 11/18/2014</footnote>
        <footnote id="F2">These options were granted pursuant to the Trimeris, Inc. 2007 Stock Incentive Plan</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Martin A. Mattingly, attorney-in-fact</signatureName>
        <signatureDate>2010-11-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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