Exhibit 24.1


AUTHORIZATION LETTER



May 4, 2007

Securities and Exchange Commission
450 Fifth Street, NW
Washington, DC 20549

Dear Sir or Madam:

By means of this letter, I hereby authorize Andrew L. Graham and Michael A. Alrutz, or either of them individually
in each of his /her capacity as Secretary; respectively, of Trimeris, Inc. (the "Company"), to sign on my behalf all forms
required under Section 16(a) of the Securities Exchange Act of 1934, as amended, relating to transactions involving the stock
or derivative securities of the Company. Either of such individuals is accordingly authorized to sign any Form ID, Form 3,
Form 4, and Form 5 or amendment thereto which I am required to file with the same effect as if I had signed them myself.

This Authorization shall remain in effect until revoked in writing by me.


Sincerely,




/s/ Daniel Ratto
___________________________
Daniel Ratto