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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 BIS645wRAWmdVWfpLLpJk2czHvP7lRUaAGKKlEJRjP8E98obn+fVddigWy6Z/7xs
 EScbEPA9g9YENPO5L03+sg==

<SEC-DOCUMENT>0001181431-04-043403.txt : 20040909
<SEC-HEADER>0001181431-04-043403.hdr.sgml : 20040909
<ACCEPTANCE-DATETIME>20040909184838
ACCESSION NUMBER:		0001181431-04-043403
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040908
FILED AS OF DATE:		20040909
DATE AS OF CHANGE:		20040909

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Skolsky Steven D
		CENTRAL INDEX KEY:			0001300868

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23155
		FILM NUMBER:		041023849

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(212)969-3000

	MAIL ADDRESS:	
		STREET 1:		C/O PROSKAUER ROSE LLP
		STREET 2:		1585 BROADWAY
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036-8299

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TRIMERIS INC
		CENTRAL INDEX KEY:			0000911326
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				561808663
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3518 WESTGATE DRIVE, SUITE 300
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27707
		BUSINESS PHONE:		9194196050

	MAIL ADDRESS:	
		STREET 1:		3518 WESTGATE DRIVE, SUITE 300
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27707
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd52368.xml
<DESCRIPTION>FORM 4 - SKOLSKY
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-09-08</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000911326</issuerCik>
        <issuerName>TRIMERIS INC</issuerName>
        <issuerTradingSymbol>TRMS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001300868</rptOwnerCik>
            <rptOwnerName>Skolsky Steven D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3518 WESTGATE DR.</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 300</rptOwnerStreet2>
            <rptOwnerCity>DURHAM</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27707</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common stock</value>
            </securityTitle>
            <transactionDate>
                <value>2004-09-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>50000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Employee stock option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>11.51</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2004-09-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>350000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2005-03-08</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-09-08</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>350000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>350000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These shares of restricted stock were granted pursuant to the Trimeris, Inc. Amended and Restated Stock Incentive Plan.  These shares vest 100% and become fully transferable on 9/8/08. In the event that the reporting person is terminated without Cause by the Company or on account of Death or Disability, or the reporting person resigns for Good Reason (as these terms are defined in the Employment Agreement between reporting person and Company dated 9/8/04) prior to 9/8/06, 50% of the shares shall become nonforfeitable on such date of termination or, if later, 3/8/05 .  In the event reporting person's employment ends as a result of one of these events occuring after 9/8/06, the stock will vest at a monthly rate for each month of service that occurs after 9/8/06.</footnote>
        <footnote id="F2">The option vests 12.5% after six months from the date of grant and on a monthly basis for the next forty-two (42) months thereafter.  In the event that the reporting person is terminated without Cause by the Company or the reporting person resigns for Good Reason (as these terms are defined in the Employment Agreement between reporting person and Company dated 9/8/04) prior to 9/8/06, 50% of the shares subject to the option shall become nonforfeitable on such date of termination.</footnote>
        <footnote id="F3">These stock options were granted pursuant to the Trimeris, Inc. Amended and Restated Stock Incentive Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Michael A. Alrutz, attorney-in-fact</signatureName>
        <signatureDate>2004-09-09</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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