-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 WMXdefNSvFXC0QyZsFpVZBZz623PPB7EKN49JF1YvsI1J/4Au4iZCEwelSyvI1Zh
 q6hkjWu8oGRLNnxihmupDg==

<SEC-DOCUMENT>0001181431-03-010120.txt : 20030605
<SEC-HEADER>0001181431-03-010120.hdr.sgml : 20030605
<ACCEPTANCE-DATETIME>20030605151639
ACCESSION NUMBER:		0001181431-03-010120
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030605
FILED AS OF DATE:		20030605

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TRIMERIS INC
		CENTRAL INDEX KEY:			0000911326
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				561808663
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3518 WESTGATE DRIVE, SUITE 300
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27707
		BUSINESS PHONE:		9194196050

	MAIL ADDRESS:	
		STREET 1:		3518 WESTGATE DRIVE, SUITE 300
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27707

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BONCZEK ROBERT R
		CENTRAL INDEX KEY:			0001183901

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23155
		FILM NUMBER:		03734081

	BUSINESS ADDRESS:	
		STREET 1:		C/O TRIMERIS, INC.
		STREET 2:		3518 WESTGATE DR. SUITE 300
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27707
		BUSINESS PHONE:		9194085018

	MAIL ADDRESS:	
		STREET 1:		C/O TRIMERIS, INC.
		STREET 2:		3518 WESTGATE DR. SUITE 300
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27707
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>rrd10565.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4/A</documentType>
<periodOfReport>2003-06-05</periodOfReport>
<dateOfOriginalSubmission>2003-06-05</dateOfOriginalSubmission>
<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000911326</issuerCik>
        <issuerName>TRIMERIS INC</issuerName>
        <issuerTradingSymbol>TRMS</issuerTradingSymbol></issuer>
<reportingOwner>
<reportingOwnerId>
            <rptOwnerCik>0001183901</rptOwnerCik>
            <rptOwnerName>BONCZEK ROBERT R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>0</isDirector>
<isOfficer>1</isOfficer>
<isTenPercentOwner>0</isTenPercentOwner>
<isOther>0</isOther>
<officerTitle>CFO and General Counsel</officerTitle>
<otherText></otherText></reportingOwnerRelationship></reportingOwner>
<derivativeSecurity>
<securityTitle>
<value>Call Options (obligation to sell)</value></securityTitle>
<conversionOrExercisePrice>
<value>60.00</value></conversionOrExercisePrice>
<transactionDate>
<value>2003-06-05</value></transactionDate>
<deemedExecutionDate>
<value>2003-06-05</value></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>S</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved></transactionCoding>
<transactionAmounts>
<transactionShares>
<value>10</value></transactionShares>
<transactionValue>
<value>200</value></transactionValue>
<transactionAcquiredDisposedCode>
<value>D</value></transactionAcquiredDisposedCode></transactionAmounts>
<exerciseDate>
<value>2003-06-05</value></exerciseDate>
<expirationDate>
<value>2004-01-16</value></expirationDate>
<underlyingSecurity>
<underlyingSecurityTitle>
<value>Common Stock</value></underlyingSecurityTitle>
<underlyingSecurityShares>
<value>1000</value></underlyingSecurityShares></underlyingSecurity>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>1000</value>
<footnoteId id="F1"/></sharesOwnedFollowingTransaction></postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value></directOrIndirectOwnership>
<natureOfOwnership>
<value></value></natureOfOwnership></ownershipNature></derivativeSecurity>
<derivativeSecurity>
<securityTitle>
<value>Call Options (obligation to sell)</value></securityTitle>
<conversionOrExercisePrice>
<value>60.00</value></conversionOrExercisePrice>
<transactionDate>
<value>2003-06-05</value></transactionDate>
<deemedExecutionDate>
<value>2003-06-05</value></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>S</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved></transactionCoding>
<transactionAmounts>
<transactionShares>
<value>10</value></transactionShares>
<transactionValue>
<value>200</value></transactionValue>
<transactionAcquiredDisposedCode>
<value>D</value></transactionAcquiredDisposedCode></transactionAmounts>
<exerciseDate>
<value>2003-06-05</value></exerciseDate>
<expirationDate>
<value>2004-01-16</value></expirationDate>
<underlyingSecurity>
<underlyingSecurityTitle>
<value>Common Stock</value></underlyingSecurityTitle>
<underlyingSecurityShares>
<value>1000</value></underlyingSecurityShares></underlyingSecurity>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>1000</value>
<footnoteId id="F1"/></sharesOwnedFollowingTransaction></postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value></directOrIndirectOwnership>
<natureOfOwnership>
<value></value></natureOfOwnership></ownershipNature></derivativeSecurity>
<derivativeSecurity>
<securityTitle>
<value>Call Options (obligation to sell)</value></securityTitle>
<conversionOrExercisePrice>
<value>60.00</value></conversionOrExercisePrice>
<transactionDate>
<value>2003-06-05</value></transactionDate>
<deemedExecutionDate>
<value>2003-06-05</value></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>S</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved></transactionCoding>
<transactionAmounts>
<transactionShares>
<value>10</value></transactionShares>
<transactionValue>
<value>210</value></transactionValue>
<transactionAcquiredDisposedCode>
<value>D</value></transactionAcquiredDisposedCode></transactionAmounts>
<exerciseDate>
<value>2003-06-05</value></exerciseDate>
<expirationDate>
<value>2004-01-16</value></expirationDate>
<underlyingSecurity>
<underlyingSecurityTitle>
<value>Common Stock</value></underlyingSecurityTitle>
<underlyingSecurityShares>
<value>1000</value></underlyingSecurityShares></underlyingSecurity>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>1000</value>
<footnoteId id="F1"/></sharesOwnedFollowingTransaction></postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value></directOrIndirectOwnership>
<natureOfOwnership>
<value></value></natureOfOwnership></ownershipNature></derivativeSecurity>
<derivativeSecurity>
<securityTitle>
<value>Call Options (obligation to sell)</value></securityTitle>
<conversionOrExercisePrice>
<value>60.00</value></conversionOrExercisePrice>
<transactionDate>
<value>2003-06-05</value></transactionDate>
<deemedExecutionDate>
<value>2003-06-05</value></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>S</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved></transactionCoding>
<transactionAmounts>
<transactionShares>
<value>10</value></transactionShares>
<transactionValue>
<value>205</value></transactionValue>
<transactionAcquiredDisposedCode>
<value>D</value></transactionAcquiredDisposedCode></transactionAmounts>
<exerciseDate>
<value>2003-06-05</value></exerciseDate>
<expirationDate>
<value>2004-01-16</value></expirationDate>
<underlyingSecurity>
<underlyingSecurityTitle>
<value>Common Stock</value></underlyingSecurityTitle>
<underlyingSecurityShares>
<value>1000</value></underlyingSecurityShares></underlyingSecurity>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>1000</value>
<footnoteId id="F1"/></sharesOwnedFollowingTransaction></postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value></directOrIndirectOwnership>
<natureOfOwnership>
<value></value></natureOfOwnership></ownershipNature></derivativeSecurity>
<derivativeSecurity>
<securityTitle>
<value>Call Options (obligation to sell)</value></securityTitle>
<conversionOrExercisePrice>
<value>60.00</value></conversionOrExercisePrice>
<transactionDate>
<value>2003-06-05</value></transactionDate>
<deemedExecutionDate>
<value>2003-06-05</value></deemedExecutionDate>
<transactionCoding>
<transactionFormType>4</transactionFormType>
<transactionCode>S</transactionCode>
<equitySwapInvolved>0</equitySwapInvolved></transactionCoding>
<transactionAmounts>
<transactionShares>
<value>10</value></transactionShares>
<transactionValue>
<value>235</value></transactionValue>
<transactionAcquiredDisposedCode>
<value>D</value></transactionAcquiredDisposedCode></transactionAmounts>
<exerciseDate>
<value>2003-06-05</value></exerciseDate>
<expirationDate>
<value>2004-01-16</value></expirationDate>
<underlyingSecurity>
<underlyingSecurityTitle>
<value>Common Stock</value></underlyingSecurityTitle>
<underlyingSecurityShares>
<value>1000</value></underlyingSecurityShares></underlyingSecurity>
<postTransactionAmounts>
<sharesOwnedFollowingTransaction>
<value>1000</value>
<footnoteId id="F1"/></sharesOwnedFollowingTransaction></postTransactionAmounts>
<ownershipNature>
<directOrIndirectOwnership>
<value>D</value></directOrIndirectOwnership>
<natureOfOwnership>
<value></value></natureOfOwnership></ownershipNature></derivativeSecurity>
<footnotes>
<footnote id="F1">This column reflects the number of shares of TRMS common stock underlying the reported call option contracts and that are beneficially owned by the reporting person.</footnote></footnotes>
<ownerSignature>
<signatureName>Michael Alrutz, Attorney-In-Fact</signatureName>
<signatureDate>2003-06-05</signatureDate></ownerSignature></ownershipDocument>


</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----