EXHIBIT 10.10

TRIMERIS, INC. EMPLOYEE 401(K) PLAN

Trimeris, Inc. Employee 401(k) Plan

ADOPTION AGREEMENT #005
NONSTANDARDIZED 401(k) PROFIT SHARING PLAN

The undersigned, Trimeris, Inc. (“Employer”), by executing this Adoption Agreement, elects to establish a retirement plan and trust (“Plan”) under the Poyner & Spruill LLP Defined Contribution Prototype Plan and Trust (basic plan document # 01). The Employer, subject to the Employer’s Adoption Agreement elections, adopts fully the Prototype Plan and Trust provisions. This Adoption Agreement, the basic plan document and any attached appendices or addenda, constitute the Employer’s entire plan and trust document. All section references within this Adoption Agreement are Adoption Agreement section references unless the Adoption Agreement or the context indicate otherwise. All article references are basic plan document and Adoption Agreement references as applicable. Numbers in parenthesis which follow headings are references to basic plan document sections. The Employer makes the following elections granted under the corresponding provisions of the basic plan document.

ARTICLE I
DEFINITIONS

1.PLAN(1.21). The name of the Plan as adopted by the Employer is Trimeris, Inc. Employee 401(k) Plan.

2.TRUSTEE(1.33). The Trustee executing this Adoption Agreement is: (Choose one of (a), (b) or (c))

o(a)   A discretionary Trustee. See Plan Section 10.03[A].

x(b)   A nondiscretionary Trustee. See Plan Section 10.03[B].

o(c)   A Trustee under a separate trust agreement. See Plan Section 10.03[G].

3.EMPLOYEE(1.11). The following Employees are not eligible to participate in the Plan: (Choose (a) or one or more of (b) through (g) as applicable)

x(a)   No exclusions.

o(b)   Collective bargaining Employees.

o(c)   Nonresident aliens.

o(d)   Leased Employees.

o(e)   Reclassified Employees.

o(f)   Classifications: _______.

o(g)   Exclusions by types of contributions. The following classification(s) of Employees are not eligible for the specified contributions:

Employee classification: _______

Contribution type: _______

4.COMPENSATION(1.07). The Employer makes the following election(s) regarding the definition of Compensation for purposes of the contribution allocation formula under Article III: (Choose one of (a), (b) or (c))

x(a)   W-2 wages increased by Elective Contributions.

o(b)   Code §3401(a) federal income tax withholding wages increased by Elective Contributions.

o(c)   415 compensation.

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[Note: Each of the Compensation definitions in (a), (b) and (c) includes Elective Contributions. See Plan Section 1.07(D). To exclude Elective Contributions, the Employer must elect (g).]

Compensation taken into account. For the Plan Year in which an Employee first becomes a Participant, the Plan Administrator will determine the allocation of Employer contributions (excluding deferral contributions) by taking into account: (Choose one of (d) or (e))

o(d)   Plan Year. The Employee’s Compensation for the entire Plan Year.

x(e)   Compensation while a Participant. The Employee’s Compensation only for the portion of the Plan Year in which the Employee actually is a Participant.

Modifications to Compensation definition. The Employer elects to modify the Compensation definition elected in (a), (b) or (c) as follows. (Choose one or more of (f) through (n) as applicable. If the Employer elects to allocate its nonelective contribution under Plan Section 3.04 using permitted disparity, (i), (j), (k) and (l) do not apply):

o(f)   Fringe benefits. The Plan excludes all reimbursements or other expense allowances, fringe benefits (cash and noncash), moving expenses, deferred compensation and welfare benefits.

o(g)   Elective Contributions. The Plan excludes a Participant’s Elective Contributions. See Plan Section 1.07(D).

o(h)   Exclusion. The Plan excludes Compensation in excess of: _______.

o(i)   Bonuses. The Plan excludes bonuses.

o(j)   Overtime. The Plan excludes overtime.

o(k)   Commissions. The Plan excludes commissions.

x(l)   Nonelective contributions. The following modifications apply to the definition of Compensation for nonelective contributions: Compensation does not include amounts realized from the exercise of a non-qualified stock option, or when restricted stock becomes freely transferable or no longer subject to a substantial risk of forfeiture, or amounts realized from the sale, exchange or other disposition of stock acquired under an incentive stock option.

x(m)   Deferral contributions. The following modifications apply to the definition of Compensation for deferral contributions: Noncash compensation is excluded, provided that Compensation shall include Elective Contributions. Compensation also does not include amounts excluded pursuant to option (n) below.

x(n)   Matching contributions. The following modifications apply to the definition of Compensation for matching contributions: Compensation does not include amounts realized from the exercise of a non-qualified stock option, or when restricted stock becomes freely transferable or is no longer subject to a substantial risk of forfeiture, or amounts realized from the sale, exchange or other disposition of stock acquired under an incentive stock option.

5.PLAN YEAR/LIMITATION YEAR(1.24). Plan Year and Limitation Year mean the 12-consecutive month period (except for a short Plan Year) ending every: (Choose (a) or (b). Choose (c) if applicable)

x(a)   December 31.

o(b)   Other: _______.

o(c)   Short Plan Year: commencing on:_______ and ending on: _______.

6.EFFECTIVE DATE(1.10). The Employer’s adoption of the Plan is a: (Choose one of (a) or (b))

o(a)   New Plan. The Effective Date of the Plan is: _______.

x(b)   Restated Plan. The restated Effective Date is: January 1, 1997.

This Plan is an amendment and restatement of an existing retirement plan(s) originally established effective as of: January 1, 1994.

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7.HOUR OF SERVICE/ELAPSED TIME METHOD(1.15). The crediting method for Hours of Service is: (Choose one or more of (a) through (d) as applicable)

x(a)   Actual Method. See Plan Section 1.15(B).

o(b)   Equivalency Method. The Equivalency Method is: ____________.[Note: Insert “daily,” “weekly,” “semi-monthly payroll periods” or “monthly.”]See Plan Section 1.15(C).

o(c)   Combination Method. In lieu of the Equivalency Method specified in (b), the Actual Method applies for purposes of: __________________.

o(d)   Elapsed Time Method. In lieu of crediting Hours of Service, the Elapsed Time Method applies for purposes of crediting Service for: (Choose one or more of (1), (2) or (3) as applicable)

o(1)   Eligibility under Article II.

o(2)   Vesting under Article V.

o(3)   Contribution allocations under Article III.

8.PREDECESSOR EMPLOYER SERVICE(1.30). In addition to the predecessor service the Plan must credit by reason of Section 1.30 of the Plan, the Plan credits as Service under this Plan, service with the following predecessor employer(s): N/A.

[Note: If the Plan does not credit any additional predecessor service under this Section 1.30, insert “N/A” in the blank line. The Employer also may elect to credit predecessor service with specified Participating Employers only. See the Participation Agreement.]Service with the designated predecessor employer(s) applies: (Choose one or more of (a) through (d) as applicable)

o(a)   Eligibility. For eligibility under Article II. See Plan Section 1.30 for time of Plan entry.

o(b)   Vesting. For vesting under Article V.

o(c)   Contribution allocation. For contribution allocations under Article III.

o(d)   Exceptions. Except for the following Service: ____________________.

ARTICLE II
ELIGIBILITY REQUIREMENTS

9.ELIGIBILITY(2.01).

Eligibility conditions. To become a Participant in the Plan, an Employee must satisfy the following eligibility conditions: (Choose one or more of (a) through (e) as applicable) [Note: If the Employer does not elect (c), the Employer’s elections under (a) and (b) apply to all types of contributions. The Employer as to deferral contributions may not elect (b)(2) and may not elect more than 12 months in (b)(4) and (b)(5).]

x(a)   Age. Attainment of age 21 (not to exceed age 21).

x(b)   Service. Service requirement. (Choose one of (1) through (5))

o(1)   One Year of Service.

o(2)   Two Years of Service, without an intervening Break in Service. See Plan Section 2.03(A).

x(3)   One Hour of Service (immediate completion of Service requirement). The Employee satisfies the Service requirement on his/her Employment Commencement Date.

o(4)    ________________ months (not exceeding 24).

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o(5)   An Employee must complete _____________ Hours of Service within the ___________ time period following the Employee’s Employment Commencement Date. If an Employee does not complete the stated Hours of Service during the specified time period (if any), the Employee is subject to the One Year of Service requirement. [Note: The number of hours may not exceed 1,000 and the time period may not exceed 24 months. If the Plan does not require the Employee to satisfy the Hours of Service requirement within a specified time period, insert “N/A” in the second blank line.]

o(c)   Alternative 401(k)/401(m) eligibility conditions. In lieu of the elections in (a) and (b), the Employer elects the following eligibility conditions for the following types of contributions: (Choose (1) or (2) or both if the Employer wishes to impose less restrictive eligibility conditions for deferral/Employee contributions or for matching contributions)

(1)o    Deferral/Employee contributions: (Choose one of a. through d. Choose e. if applicable)

a.o    One Year of Service

b.o    One Hour of Service (immediate completion of Service requirement)

c.o    _______________ months (not exceeding 12)

d.o    An Employee must complete ______________ Hours of Service within the ____________ time period following an Employee’s Employment Commencement Date. If an Employee does not complete the stated Hours of Service during the specified time period (if any), the Employee is subject to the One Year of Service requirement. [Note: The number of hours may not exceed 1,000 and the time period may not exceed 12 months. If the Plan does not require the Employee to satisfy the Hours of Service requirement within a specified time period, insert “N/A” in the second blank line.]

e.o    Age __________________ (not exceeding age 21)

(2)o   Matching contributions: (Choose one of f. through i. Choose j. if applicable)

f.o    One Year of Service

g.o    One Hour of Service (immediate completion of Service requirement)

h.o     ________________ months (not exceeding 24)

i.o    An Employee must complete ___________ Hours of Service within the __________ time period following an Employee’s Employment Commencement Date. If an Employee does not complete the stated Hours of Service during the specified time period (if any), the Employee is subject to the One Year of Service requirement. [Note: The number of hours may not exceed 1,000 and the time period may not exceed 24 months. If the Plan does not require the Employee to satisfy the Hours of Service requirement within a specified time period, insert “N/A” in the second blank line.]

j.o    Age _____________ (not exceeding age 21)

o(d)   Service requirements: __________________.
[Note: Any Service requirement the Employer elects in (d) must be available under other Adoption Agreement elections or a combination thereof.]

o(e)   Dual eligibility. The eligibility conditions of this Section 2.01 apply solely to an Employee employed by the Employer after ________________. If the Employee was employed by the Employer by the specified date, the Employee will become a Participant on the latest of: (i) the Effective Date; (ii) the restated Effective Date; (iii) the Employee’s Employment Commencement Date; or (iv) on the date the Employee attains age ______________ (not exceeding age 21).

Plan Entry Date. “Plan Entry Date” means the Effective Date and: (Choose one of (f) through (j). Choose (k) if applicable) [Note: If the Employer does not elect (k), the elections under (f) through( j) apply to all types of contributions. The Employer must elect at least one Entry Date per Plan Year.]

o(f)   Semi-annual Entry Dates. The first day of the Plan Year and the first day of the seventh month of the Plan Year.

o(g)   The first day of the Plan Year.

o(h)   Employment Commencement Date (immediate eligibility).

o(i)   The first day of each: _________________ (e.g.,“Plan Year quarter”).

x(j)   The following Plan Entry Dates: Each Business Day .

x(k)   Alternative 401(k)/401(m) Plan Entry Date(s). For the alternative 401(k)/401(m) eligibility conditions under (c), Plan Entry Date means: (Choose (1) or (2) or both as applicable)

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(1)	x	Deferral/Employee contributions (Choose one of a. through d.)		(2)	o	Matching contributions (Choose one of e. through h.)
	a.	o	Semi - annual Entry Dates		e.	o	Semi - annual Entry Dates
	b.	o	The first day of the Plan Year		f.	o	The first day of the Plan Year
	c.	o	Employment Commencement Date (immediate eligibility)		g.	o	Employment Commencement Date (immediate eligibility)
	d.	x	The first day of each: month		h.	o	The first day of each: ________

Time of participation. An Employee will become a Participant, unless excluded under Section 1.11, on the Plan Entry Date (if employed on that date): (Choose one of (l), (m) or (n). Choose (o) if applicable): [Note: If the Employer does not elect (o), the election under (l), (m) or (n) applies to all types of contributions.]

x(l)   Immediately following or coincident with

o(m)   Immediately preceding or coincident with

o(n)   Nearest

o(o)   Alternative 401(k)/401(m) election(s): (Choose(1) or (2) or both as applicable)

(1)	o	Deferral contributions		(2)	o	Matching contributions (Choose one of b., c. or d.)
	a.	o	Immediately following or coincident with		b.	o	Immediately following or coincident with
					c.	o	Immediately preceding or coincident with
					d.	o	Nearest

the date the Employee completes the eligibility conditions described in this Section 2.01. [Note: Unless otherwise excluded under Section 1.11, an Employee must become a Participant by the earlier of: (1) the first day of the Plan Year beginning after the date the Employee completes the age and service requirements of Code §410(a); or (2) 6 months after the date the Employee completes those requirements.]

10.YEAR OF SERVICE - ELIGIBILITY(2.02). (Choose (a) and (b) as applicable): [Note: If the Employer does not elect a Year of Service condition or elects the Elapsed Time Method, the Employer should not complete (a) or (b).]

o(a)   Year of Service. An Employee must complete _____________ Hour(s) of Service during an eligibility computation period to receive credit for a Year of Service under Article II: [Note: The number may not exceed 1,000. If left blank, the requirement is 1,000.]

o(b)   Eligibility computation period. After the initial eligibility computation period described in Plan Section 2.02, the Plan measures the eligibility computation period as: (Choose one of (1) or (2))

o(1)   The Plan Year beginning with the Plan Year which includes the first anniversary of the Employee’s Employment Commencement Date.

o(2)   The 12-consecutive month period beginning with each anniversary of the Employee’s Employment Commencement Date.

11.PARTICIPATION - BREAK IN SERVICE(2.03). The one year hold-out rule described in Plan Section 2.03(B): (Choose one of (a), (b) or (c))

x(a)   Not applicable. Does not apply to the Plan.

o(b)   Applicable. Applies to the Plan and to all Participants.

o(c)   Limited application. Applies to the Plan, but only to a Participant who has incurred a Separation from Service.

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12.ELECTION NOT TO PARTICIPATE(2.06). The Plan: (Choose one of (a) or (b))

x(a)   Election not permitted. Does not permit an eligible Employee to elect not to participate.

o(b)   Irrevocable election. Permits an Employee to elect not to participate if the Employee makes a one-time irrevocable election prior to the Employee’s Plan Entry Date.

ARTICLE III
EMPLOYER CONTRIBUTIONS, DEFERRAL CONTRIBUTIONS AND FORFEITURES

13.AMOUNT AND TYPE(3.01). The amount and type(s) of the Employer’s contribution to the Trust for a Plan Year or other specified period will equal: (Choose one or more of (a) through (f) as applicable)

x(a)   Deferral contributions (401(k) arrangement). The dollar or percentage amount by which each Participant has elected to reduce his/her Compensation, as provided in the Participant’s salary reduction agreement and in accordance with Section 3.02.

x(b)   Matching contributions (other than safe harbor matching contributions under Section 3.01(d)). The matching contributions made in accordance with Section 3.03.

x(c)   Nonelective contributions (profit sharing). The following nonelective contribution (Choose(1) or (2) or both as applicable): [Note: The Employer may designate as a qualified nonelective contribution, all or any portion of its nonelective contribution. See Plan Section 3.04(F).]

x(1)   Discretionary. An amount the Employer in its sole discretion may determine.

o(2)   Fixed. The following amount: ___________

o(d)   401(k) safe harbor contributions. The following 401(k) safe harbor contributions described in Plan Section 14.02(D): (Choose one of (1), (2) or (3). Choose (4), if applicable)

o(1)   Safeharbor nonelective contribution. The safe harbor nonelective contribution equals ____% of a Participant’s Compensation [Note: the amount in the blank must be at least 3%].

o(2)   Basic safe harbor matching contribution. A matching contribution equal to 100% of each Participant’s deferral contributions not exceeding 3% of the Participant’s Compensation, plus 50% of each Participant’s deferral contributions in excess of 3% but not in excess of 5% of the Participant’s Compensation. For this purpose, “Compensation” means Compensation for:________. [Note: The Employer must complete the blank line with the applicable time period for computing the Employer’s basic safe harbor match, such as “each payroll period,” “each month,” “each Plan Year quarter” or “the Plan Year”. ]

o(3)   Enhanced safe harbor matching contribution. (Choose one of a. or b.).

oa.   Uniform percentage. An amount equal to ______% of each Participant’s deferral contributions not exceeding ______% of the Participant’s Compensation. For this purpose, “Compensation” means Compensation for:________. [See the Note in (d)(2).]

ob.   Tiered formula. An amount equal to the specified matching percentage for the corresponding level of each Participant’s deferral contribution percentage. For this purpose, “Compensation” means Compensation for:______. [See the Note in (d)(2).]

Deferral Contribution Percentage Matching Percentage

[Note: The matching percentage may not increase as the deferral contribution percentage increases and the enhanced matching formula otherwise must satisfy the requirements of Code §§401(k)(12)(B)(ii) and (iii). If the Employer wishes to avoid ACP testing on its enhanced safe harbor matching contribution, the Employer also must limit deferral contributions taken into account (the “Deferral Contribution Percentage”) for the matching contribution to 6% of Plan Year Compensation.]

o(4)   Another plan. The Employer will satisfy the 401(k) safe harbor contribution in the following plan:______.

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o(e)   Davis-Bacon contributions. The amount(s) specified for the applicable Plan Year or other applicable period in the Employer’s Davis-Bacon contract(s). The Employer will make a contribution only to Participants covered by the contract and only with respect to Compensation paid under the contract. If the Participant accrues an allocation of nonelective contributions (including forfeitures) under the Plan in addition to the Davis-Bacon contribution, the Plan Administrator will: (Choose one of (1) or (2))

o(1)   Not reduce the Participant’s nonelective contribution allocation by the Davis-Bacon contribution.

o(2)   Reduce the Participant’s nonelective contribution allocation by the Davis-Bacon contribution.

o(f)   Frozen Plan. This Plan is a frozen Plan effective: _______. For any period following the specified date, the Employer will not contribute to the Plan, a Participant may not contribute and an otherwise eligible Employee will not become a Participant in the Plan.

14.DEFERRAL CONTRIBUTIONS(3.02). The following limitations and terms apply to an Employee’s deferral contributions: (If the Employer elects Section 3.01(a), the Employer must elect (a). Choose (b) or (c) as applicable)

x(a)   Limitation on amount. An Employee’s deferral contributions are subject to the following limitation(s) in addition to those imposed by the Code: (Choose (1), (2) or (3) as applicable)

x(1)   Maximum deferral amount: 75% of Compensation.

o(2)   Minimum deferral amount: _____.

o(3)   No limitations.

For the Plan Year in which an Employee first becomes a Participant, the Plan Administrator will apply any percentage limitation the Employer elects in (1) or (2) to the Employee’s Compensation: (Choose one of (4) or (5) unless the Employer elects (3))

x(4)   Only for the portion of the Plan Year in which the Employee actually is a Participant.

o(5)   For the entire Plan Year.

o(b)   Negative deferral election. The Employer will withhold _____% from the Participant’s Compensation unless the Participant elects a lesser percentage (including zero) under his/her salary reduction agreement. See Plan Section 14.02(C). The negative election will apply to: (Choose one of (1) or (2))

o(1)   All Participants who have not deferred at least the automatic deferral amount as of:______.

o(2)   Each Employee whose Plan Entry Date is on or following the negative election effective date.

o(c)   Cash or deferred contributions. For each Plan Year for which the Employer makes a designated cash or deferred contribution under Plan Section 14.02(B), a Participant may elect to receive directly in cash not more than the following portion (or, if less, the 402(g) limitation) of his/her proportionate share of that cash or deferred contribution: (Choose one of (1) or (2))

o      (1)   All or any portion. o      (2)   _______%.

Modification/revocation of salary reduction agreement. A Participant prospectively may modify or revoke a salary reduction agreement, or may file a new salary reduction agreement following a prior revocation, at least once per Plan Year or during any election period specified by the basic plan document or required by the Internal Revenue Service. The Plan Administrator also may provide for more frequent elections in the Plan’s salary reduction agreement form.

15.MATCHING CONTRIBUTIONS (INCLUDING ADDITIONAL SAFE HARBOR MATCH UNDER PLAN SECTION 14.02(D)(3))(3.03). The Employer matching contribution is: (If the Employer elects Section 3.01(b), the Employer must elect one or more of (a), (b) or (c) as applicable. Choose (d) if applicable)

o(a)   Fixed formula. An amount equal to ______% of each Participant’s deferral contributions.

x(b)   Discretionary formula. An amount (or additional amount) equal to a matching percentage the Employer from time to time may deem advisable of the Participant’s deferral contributions. The Employer, in its sole discretion, may designate as a qualified matching contribution, all or any portion of its discretionary matching contribution. The portion

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of the Employer’s discretionary matching contribution for a Plan Year not designated as a qualified matching contribution is a regular matching contribution.

o(c)   Multiple level formula. An amount equal to the following percentages for each level of the Participant’s deferral contributions. [Note: The matching percentage only will apply to deferral contributions in excess of the previous level and not in excess of the stated deferral contribution percentage.]

Deferral Contributions Matching Percentage

o(d)   Related Employers. If two or more Related Employers contribute to this Plan, the Plan Administrator will allocate matching contributions and matching contribution forfeitures only to the Participants directly employed by the contributing Employer. The matching contribution formula for the other Related Employer(s) is:______. [Note: If the Employer does not elect (d), the Plan Administrator will allocate all matching contributions and matching forfeitures without regard to which contributing Related Employer directly employs the Participant.]

Time period for matching contributions. The Employer will determine its matching contribution based on deferral contributions made during each: (Choose one of (e) through (h))

x(e)   Plan Year.

o(f)   Plan Year quarter.

o(g)   Payroll period.

o(h)   Alternative time period: _________.[Note: Any alternative time period the Employer elects in (h) must be the same for all Participants and may not exceed the Plan Year.]

Deferral contributions taken into account. In determining a Participant’s deferral contributions taken into account for the above-specified time period under the matching contribution formula, the following limitations apply: (Choose one of (i),(j) or (k))

o(i)   Alldeferral contributions. The Plan Administrator will take into account all deferral contributions.

x(j)   Specific limitation. The Plan Administrator will disregard deferral contributions exceeding 12% of the Participant’s Compensation. [Note: To avoid the ACP test in a safe harbor 401(k) plan, the Employer must limit deferrals and Employee contributions which are subject to match to 6% of Plan Year Compensation.]

o(k)   Discretionary. The Plan Administrator will take into account the deferral contributions as a percentage of the Participant’s Compensation as the Employer determines.

Other matching contribution requirements. The matching contribution formula is subject to the following additional requirements: (Choose (l) or (m) or both if applicable)

o(1)   Matching contribution limits. A Participant’s matching contributions may not exceed: (Choose one of (1) or (2))

o(1)   ______. [Note: The Employer may elect (1) to place an overall dollar or percentage limit on matching contributions.]

o(2)   4% of a Participant’s Compensation for the Plan Year under the discretionary matching contribution formula. [Note: The Employer must elect (2) if it elects a discretionary matching formula with the safe harbor 401(k) contribution formula and wishes to avoid the ACP test.]

o(m)   Qualified matching contributions. The Plan Administrator will allocate as qualified matching contributions, the matching contributions specified in Adoption Agreement Section:_____. The Plan Administrator will allocate all other matching contributions as regular matching contributions. [Note: If the Employer elects two matching formulas, the Employer may use (m) to designate one of the formulas as a qualified matching contribution.]

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16.CONTRIBUTION ALLOCATION(3.04).

Employer nonelective contributions (3.04(A)). The Plan Administrator will allocate the Employer’s nonelective contribution under the following contribution allocation formula: (Choose one of (a), (b) or (c). Choose (d) if applicable)

x(a)   Nonintegrated (pro rata) allocation formula.

o(b)   Permitted disparity. The following permitted disparity formula and definitions apply to the Plan: (Choose one of (1) or (2). Also choose (3))

o(1)   Two-tiered allocation formula.

o(2)   Four-tiered allocation formula.

o(3)   For purposes of Section 3.04(b), “Excess Compensation” means Compensation in excess of: (Choose one of a. or b.)

oa.    ____% of the taxable wage base in effect on the first day of the Plan Year, rounded to the next highest $ ______ (not exceeding the taxable wage base).

ob.    The following integration level: ________.
[Note: The integration level cannot exceed the taxable wage base in effect for the Plan Year for which this Adoption Agreement first is effective.]

o(c)   Uniform points allocation formula. Under the uniform points allocation formula, a Participant receives: (Choose (1) or both (1) and (2) as applicable)

o(1)   _____ point(s) for each Year of Service. Year of Service means: _______.

o(2)   One point for each $ ____ [not to exceed $200]increment of Plan Year Compensation.

o(d)   Incorporation of contribution formula. The Plan Administrator will allocate the Employer’s nonelective contribution under Section(s) 3.01(c)(2), (d)(1) or (e) in accordance with the contribution formula adopted by the Employer under that Section.

Qualified nonelective contributions. (3.04(F)). The Plan Administrator will allocate the Employer’s qualified nonelective contributions to: (Choose one of (e) or (f))

x(e)   Nonhighly compensated Employees only.

o(f)   All Participants.

Related Employers. (Choose (g) if applicable)

o(g)   Allocate only to directly employed Participants. If two or more Related Employers adopt this Plan, the Plan Administrator will allocate all nonelective contributions and forfeitures attributable to nonelective contributions only to the Participants directly employed by the contributing Employer. If a Participant receives Compensation from more than one contributing Employer, the Plan Administrator will determine the allocations under this Section 3.04 by prorating the Participant’s Compensation between or among the participating Related Employers. [Note: If the Employer does not elect 3.04(g), the Plan Administrator will allocate all nonelective contributions and forfeitures without regard to which contributing Related Employer directly employs the Participant. The Employer may not elect 3.04(g) under a safe harbor 401(k) Plan.]

17.FORFEITURE ALLOCATION(3.05). The Plan Administrator will allocate a Participant forfeiture: (Choose one or more of (a), (b) or (c) as applicable) [Note: Even if the Employer elects immediate vesting, the Employer should complete Section 3.05. See Plan Section 9.11.]

x(a)   Matching contribution forfeitures. To the extent attributable to matching contributions: (Choose one of (1) through (4))

x(1)   As a discretionary matching contribution.

o(2)   To reduce matching contributions.

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o(3)   As a discretionary nonelective contribution.

o(4)   To reduce nonelective contributions.

x(b)     Nonelective contribution forfeitures. To the extent attributable to Employer nonelective contributions: (Choose one of (1) through (4))

x(1)   As a discretionary nonelective contribution.

o(2)   To reduce nonelective contributions.

o(3)   As a discretionary matching contribution.

o(4)   To reduce matching contributions.

o(c)   Reduce administrative expenses. First to reduce the Plan’s ordinary and necessary administrative expenses for the Plan Year and then allocate any remaining forfeitures in the manner described in Sections 3.05(a) or (b) as applicable.

Timing of forfeiture allocation. The Plan Administrator will allocate forfeitures under Section 3.05 in the Plan Year: (Choose one of (d) or (e))

x(d)   In which the forfeiture occurs.

o(e)   Immediately following the Plan Year in which the forfeiture occurs.

18.ALLOCATION CONDITIONS(3.06).

Allocation conditions. The Plan does not apply any allocation conditions to deferral contributions, 401(k) safe harbor contributions (under Section 3.01(d)) or to Davis-Bacon contributions (except as the Davis-Bacon contract provides). To receive an allocation of matching contributions, nonelective contributions, qualified nonelective contributions or Participant forfeitures, a Participant must satisfy the following allocation condition(s): (Choose one or more of (a) through (i) as applicable)

o(a)   Hours of Service condition. The Participant must complete at least the specified number of Hours of Service (not exceeding 1,000) during the Plan Year: _______.

x(b)   Employment condition. The Participant must be employed by the Employer on the last day of the Plan Year (designate time period).

o(c)   No allocation conditions.

o(d)   Elapsed Time Method. The Participant must complete at least the specified number (not exceeding 182) of consecutive calendar days of employment with the Employer during the Plan Year: _______.

o(e)   Termination of Service/501 Hours of Service coverage rule. The Participant either must be employed by the Employer on the last day of the Plan Year or must complete at least 501 Hours of Service during the Plan Year. If the Plan uses the Elapsed Time Method of crediting Service, the Participant must complete at least 91 consecutive calendar days of employment with the Employer during the Plan Year.

o(f)   Special allocation conditions for matching contributions. The Participant must complete at least _______ Hours of Service during the ______ (designate time period) for the matching contributions made for that time period.

o(g)   Death, Disability or Normal Retirement Age. Any condition specified in Section 3.06 _______ applies if the Participant incurs a Separation from Service during the Plan Year on account of: _______ (e.g., death, Disability or Normal Retirement Age).

o(h)   Suspension of allocation conditions for coverage. The suspension of allocation conditions of Plan Section 3.06(E) applies to the Plan.

o(i)   Limited allocation conditions. The Plan does not impose an allocation condition for the following types of contributions: _______. [Note: Any election to limit the Plan’s allocation conditions to certain contributions must be the same for all Participants, be definitely determinable and not discriminate in favor of Highly Compensated Employees.]

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Trimeris, Inc. Employee 401(k) Plan

ARTICLE IV
PARTICIPANT CONTRIBUTIONS

19.EMPLOYEE (AFTER TAX) CONTRIBUTIONS(4.02). The following elections apply to Employee contributions: (Choose one of (a) or (b). Choose (c) if applicable)

x(a)   Not permitted. The Plan does not permit Employee contributions.

o(b)   Permitted. The Plan permits Employee contributions subject to the following limitations:_______.
[Note: Any designated limitation(s) must be the same for all Participants, be definitely determinable and not discriminate in favor of Highly Compensated Employees.]

o(c)   Matching contribution. For each Plan Year, the Employer’s matching contribution made with respect to Employee contributions is: _______.

ARTICLE V
VESTING REQUIREMENTS

20.NORMAL/EARLY RETIREMENT AGE(5.01). A Participant attains Normal Retirement Age (or Early Retirement Age, if applicable) under the Plan on the following date: (Choose one of (a) or (b). Choose (c) if applicable)

o(a)   Specific age. The date the Participant attains age _______. [Note: The age may not exceed age 65.]

x(b)   Age/participation. The later of the date the Participant attains 65 years of age or the 5th anniversary of the first day of the Plan Year in which the Participant commenced participation in the Plan. [Note: The age may not exceed age 65 and the anniversary may not exceed the 5th.]

o(c)   Early Retirement Age. Early Retirement Age is the later of: (i) the date a Participant attains age _______ or (ii) the date a Participant reaches his/her _______ anniversary of the first day of the Plan Year in which the Participant commenced participation in the Plan.

21.PARTICIPANTS DEATH OR DISABILITY(5.02). The 100% vesting rule under Plan Section 5.02 does not apply to: (Choose (a) or (b) or both as applicable)

o(a)   Death.

o(b)   Disability.

22.VESTING SCHEDULE(5.03). A Participant has a 100% Vested interest at all times in his/her deferral contributions, qualified nonelective contributions, qualified matching contributions, 401(k) safe harbor contributions and Davis-Bacon contributions (unless otherwise indicated in (f)). The following vesting schedule applies to Employer regular matching contributions and to Employer nonelective contributions: (Choose (a) or choose one or more of (b) through (f) as applicable)

o(a)   Immediate vesting. 100% Vested at all times. [Note: The Employer must elect (a) if the Service condition under Section 2.01 exceeds One Year of Service or more than twelve months.]

x(b)   Top-heavy vesting schedules. [Note: The Employer must choose one of (b)(1), (2) or (3) if it does not elect (a).]

o(1)   6-year graded as specified in the Plan	x(3)   Modified top-heavy schedule
o(2)   3-year cliff as specified in the Plan.

Years of Service	Vested Percentage
Less than 1	0%
1	25%
2	50%
3	75%

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Trimeris, Inc. Employee 401(k) Plan

         4 100%

o(c)   Non-top-heavy vesting schedules. [Note: The Employer may elect one of (c)(1), (2) or (3) in addition to (b).]

o(1)   7-year graded as specified in the Plan.	o(3)   Modified non-top-heavy schedule
o(2)   5-year cliff as specified in the Plan.

Years of Service	Vested Percentage
Less than 1	___%
1	___%
2	___%
3	___%
4	___%
5	___%
6	___%
7 or more	100%

If the Employer does not elect (c), the vesting schedule elected in (b) applies to all Plan Years. [Note: The modified top-heavy schedule of (b)(3) must satisfy Code §416. If the Employer elects (c)(3), the modified non-top-heavy schedule must satisfy Code §411 (a)(2).]

o(d)   Separate vesting election for regular matching contributions. In lieu of the election under (a), (b) or (c), the following vesting schedule applies to a Participant’s regular matching contributions: (Choose one of (1) or (2))

o(1)   100% Vested at all times.

o(2)   Regular matching vesting schedule: _______.
[Note: The vesting schedule completed under (d)(2) must comply with Code §411(a)(4).]

o(e)   Application of top-heavy schedule. The non-top-heavy schedule elected under (c) applies in all Plan Years in which the Plan is not a top-heavy plan. [Note: If the Employer does not elect (e), the top-heavy vesting schedule will apply for the first Plan Year in which the Plan is top-heavy and then in all subsequent Plan Years.]

o(f)   Special vesting provisions: _______. [Note: Any special vesting provision must satisfy Code §411(a). Any special vesting provision must be definitely determinable, not discriminate in favor of Highly Compensated Employees and not violate Code §401 (a)(4).]

23.YEAR OF SERVICE - VESTING(5.06). (Choose (a) and (b)): [Note: If the Employer elects the Elapsed Time Method or elects immediate vesting, the Employer should not complete (a) or (b).]

x(a)   Year of Service. An Employee must complete at least 1000 Hours of Service during a vesting computation period to receive credit for a Year of Service under Article V. [Note: The number may not exceed 1,000. If left blank, the requirement is 1,000.]

x(b)   Vesting computation period. The Plan measures a Year of Service on the basis of the following 12-consecutive month period: (Choose one of (1) or (2))

x(1)   Plan Year.

o(2)   Employment year (anniversary of Employment Commencement Date).

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Trimeris, Inc. Employee 401(k) Plan

24. EXCLUDED YEARS OF SERVICE - VESTING(5.08). The Plan excludes the following Years of Service for purposes of vesting: (Choose (a) or choose one or more of (b) through (f) as applicable)

x(a)   None. None other than as specified in Plan Section 5.08(a).

o(b)   Age 18. Any Year of Service before the Year of Service during which the Participant attained the age of 18.

o(c)   Prior to Plan establishment. Any Year of Service during the period the Employer did not maintain this Plan or a predecessor plan.

o(d)   Parity Break in Service. Any Year of Service excluded under the rule of parity. See Plan Section 5.10.

o(e)   Prior Plan terms. Any Year of Service disregarded under the terms of the Plan as in effect prior to this restated Plan.

o(f)   Additional exclusions. Any Year of Service before: _______.
[Note: Any exclusion specified under (f) must comply with Code §411(a)(4). Any exclusion must be definitely determinable, not discriminate in favor of Highly Compensated Employees and not violate Code §401(a)(4). If the Employer elects immediate vesting, the Employer should not complete Section 5.08. ]

ARTICLE VI
DISTRIBUTION OF ACCOUNT BALANCE

25.TIME OF PAYMENT OF ACCOUNT BALANCE(6.01). The following time of distribution elections apply to the Plan:

Separation from Service/Vested Account Balance not exceeding $5,000. Subject to the limitations of Plan Section 6.01(A)(1), the Trustee will distribute in a lump sum (regardless of the Employer’s election under Section 6.04) a separated Participant’s Vested Account Balance not exceeding $5,000: (Choose one of (a) through (d))

x(a)   Immediate. As soon as administratively practicable following the Participant’s Separation from Service.

o(b)   Designated Plan Year. As soon as administratively practicable in the _______Plan Year beginning after the Participant’s Separation from Service.

o(c)   Designated Plan Year quarter. As soon as administratively practicable in the _______ Plan Year quarter beginning after the Participant’s Separation from Service.

o(d)   Designated distribution. As soon as administratively practicable in the: ________ following the Participant’s Separation from Service. [Note: The designated distribution time must be the same for all Participants, be definitely determinable, not discriminate in favor of Highly Compensated Employees and not violate Code §401(a)(4).]

Separation from Service/Vested Account Balance exceeding $5,000. A separated Participant whose Vested Account Balance exceeds $5,000 may elect to commence distribution of his/her Vested Account Balance no earlier than: (Choose one of (e) through (i). Choose (j) if applicable)

x(e)   Immediate. As soon as administratively practicable following the Participant’s Separation from Service.

o(f)   Designated Plan Year. As soon as administratively practicable in the _______ Plan Year beginning after the Participant’s Separation from Service.

o(g)   Designated Plan Year quarter. As soon as administratively practicable in the _______ Plan Year quarter following the Plan Year quarter in which the Participant elects to receive a distribution.

o(h)   Normal Retirement Age. As soon as administratively practicable after the close of the Plan Year in which the Participant attains Normal Retirement Age and within the time required under Plan Section 6.01(A)(2).

o(i)   Designated distribution. As soon as administratively practicable in the: _______ following the Participant’s Separation from Service. [Note: The designated distribution time must be the same for all Participants, be definitely determinable, not discriminate in favor of Highly Compensated Employees and not violate Code §401 (a)(4).]

o(j)   Limitation on Participant’s right to delay distribution. A Participant may not elect to delay commencement of distribution of his/her Vested Account Balance beyond the later of attainment of age 62 or Normal Retirement Age.

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Trimeris, Inc. Employee 401(k) Plan

[Note: If the Employer does not elect ( j), the Plan permits a Participant who has Separated from Service to delay distribution until his/her required beginning date. See Plan Section 6.01(A)(2).]

Participant elections prior to Separation from Service. A Participant, prior to Separation from Service may elect any of the following distribution options in accordance with Plan Section 6.01(C). (Choose (k) or choose one or more of (l) through (o) as applicable). [Note: If the Employer elects any in-service distributions option, a Participant may elect to receive one in-service distribution per Plan Year unless the Plan’s in-service distribution form provides for more frequent in-service distributions.]

o(k)   None. A Participant does not have any distribution option prior to Separation from Service, except as may be provided under Plan Section 6.01(C).

x(l)   Deferral contributions. Distribution of all or any portion (as permitted by the Plan) of a Participant’s Account Balance attributable to deferral contributions if: (Choose one or more of (1), (2) or (3) as applicable)

x(1)   Hardship (safe harbor hardship rule). The Participant has incurred a hardship in accordance with Plan Sections 6.09 and 14.11(A).

o(2)   Age. The Participant has attained age _______ (Must be at least age 59 1/2).

o(3)   Disability. The Participant has incurred a Disability.

o(m)   Qualified nonelective contributions/qualified matching contributions/safe harbor contributions. Distribution of all or any portion of a Participant’s Account Balance attributable to qualified nonelective contributions, to qualified matching contributions, or to 401(k) safe harbor contributions if: (Choose (1) or (2) or both as applicable)

o(1)   Age. The Participant has attained age _________ (Must be at least age 59 1/2 ).

o(2)   Disability. The Participant has incurred a Disability.

x(n)   Nonelective contributions/regular matching contributions. Distribution of all or any portion of a Participant’s Vested Account Balance attributable to nonelective contributions or to regular matching contributions if: (Choose one or more of (1) through (5) as applicable)

o(1)   Age/Service conditions.(Choose one or more of a. through d. as applicable):

oa.   Age. The Participant has attained age _________.

ob.   Two-year allocations. The Plan Administrator has allocated the contributions to be distributed for a period of not less than _________ Plan Years before the distribution date. [Note: The minimum number of years is 2.]

oc.   Five years of participation. The Participant has participated in the Plan for at least _________ Plan Years. [Note: The minimum number of years is 5.]

od.   Vested. The Participant is _________ % Vested in his/her Account Balance. See Plan Section 5.03(A). [Note: If an Employer makes more than one election under Section 6.01(n)(1), a Participant must satisfy all conditions before the Participant is eligible for the distribution.]

o(2)   Hardship. The Participant has incurred a hardship in accordance with Plan Section 6.09.

x(3)   Hardship (safe harbor hardship rule). The Participant has incurred a hardship in accordance with Plan Sections 6.09 and 14.11(A).

o(4)   Disability. The Participant has incurred a Disability.

x(5)   Designated condition. The Participant has satisfied the following condition(s): Hardship distribution is available only if the Participant is 100% vested.
[Note: Any designated condition(s) must be the same for all Participants, be definitely determinable and not discriminate in favor of Highly Compensated Employees.]

x(o)   Participant contributions. Distribution of all or any portion of a Participant’s Account Balance attributable to the following Participant contributions described in Plan Section 4.01: (Choose one of (1), (2) or (3))

o(1)   All Participant contributions.

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Trimeris, Inc. Employee 401(k) Plan

o(2)   Employee contributions only.

x(3)   Rollover contributions only.

Participantloan default/offset. See Section 6.08 of the Plan.

26.DISTRIBUTION METHOD(6.03). A separated Participant whose Vested Account Balance exceeds $5,000 may elect distribution under one of the following method(s) of distribution described in Plan Section 6.03: (Choose one or more of (a) through (d) as applicable)

x(a)   Lump sum.

x(b)   Installments.

o(c)   Installmentsfor required minimum distributions only.

o(d)   Annuity distribution option(s): _________.
[Note: Any optional method of distribution may not be subject to Employer, Plan Administrator or Trustee discretion.]

27.JOINT AND SURVIVOR ANNUITY REQUIREMENTS(6.04). The joint and survivor annuity distribution requirements of Plan Section 6.04: (Choose one of (a) or (b))

x(a)   Profit sharing plan exception. Do not apply to a Participant, unless the Participant is a Participant described in Section 6.04(H) of the Plan.

o(b)   Applicable. Apply to all Participants.

ARTICLE IX
PLAN ADMINISTRATOR - DUTIES WITH RESPECT TO PARTICIPANTS’ ACCOUNTS

28.ALLOCATION OF NET INCOME, GAIN OR LOSS(9.08). For each type of contribution provided under the Plan, the Plan allocates net income, gain or loss using the following method: (Choose one or more of (a) through (e) as applicable)

x(a)   Deferral contributions/Employee contributions. (Choose one or more of (1) through (5) as applicable)

x(1)   Daily valuation method. Allocate on each business day of the Plan Year during which Plan assets for which there is an established market are valued and the Trustee is conducting business.

o(2)   Balance forward method. Allocate using the balance forward method.

o(3)   Weighted average method. Allocate using the weighted average method, based on the following weighting period: _________. See Plan Section 14.12.

o(4)   Balance forward method with adjustment. Allocate pursuant to the balance forward method, except treat as part of the relevant Account at the beginning of the valuation period _________ % of the contributions made during the following valuation period: _________.

o(5)   Individual account method. Allocate using the individual account method. See Plan Section 9.08.

x(b)   Matching contributions. (Choose one or more of (1) through (5) as applicable)

x(1)   Daily valuation method. Allocate on each business day of the Plan Year during which Plan assets for which there is an established market are valued and the Trustee is conducting business.

o(2)   Balance forward method. Allocate using the balance forward method.

o(3)   Weighted average method. Allocate using the weighted average method, based on the following weighting period: _________. See Plan Section 14.12.

o(4)   Balance forward method with adjustment. Allocate pursuant to the balance forward method, except treat as part of the relevant Account at the beginning of the valuation period _________ % of the contributions made during the following valuation period: _________.

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Trimeris, Inc. Employee 401(k) Plan

o(5)   Individual account method. Allocate using the individual account method. See Plan Section 9.08.

x(c)   Employer nonelective contributions. (Choose one or more of (1) through (5) as applicable)

x(1)   Daily valuation method. Allocate on each business day of the Plan Year during which Plan assets for which there is an established market are valued and the Trustee is conducting business.

o(2)   Balance forward method. Allocate using the balance forward method.

o(3)   Weighted average method. Allocate using the weighted average method, based on the following weighting period: _________. See Plan Section 14.12.

o(4)   Balance forward method with adjustment. Allocate pursuant to the balance forward method, except treat as part of the relevant Account at the beginning of the valuation period _________ % of the contributions made during the following valuation period: _________.

o(5)   Individual account method. Allocate using the individual account method. See Plan Section 9.08.

o(d)   Specified method. Allocate pursuant to the following method: _________.
[Note: The specified method must be a definite predetermined formula which is not based on Compensation, which satisfies the nondiscrimination requirements of Treas. Reg. §1.401(a)(4) and which is applied uniformly to all Participants.]

o(e)   Interest rate factor. In accordance with Plan Section 9.08(E), the Plan includes interest at the following rate on distributions made more than 90 days after the most recent valuation date: _________.

ARTICLE X
TRUSTEE AND CUSTODIAN, POWERS AND DUTIES

29.INVESTMENT POWERS(10.03). The following additional investment options or limitations apply under Plan Section 10.03: Up to 100% of matching contribution accounts may be invested in Trimeris, Inc. common stock. [Note: Enter “N/A” if not applicable.]

30.VALUATION OF TRUST(10.15). In addition to the last day of the Plan Year, the Trustee must value the Trust Fund on the following valuation date(s): (Choose one of (a) through (d))

x(a)   Daily valuation dates. Each business day of the Plan Year on which Plan assets for which there is an established market are valued and the Trustee is conducting business.

o(b)   Last day of a specified period. The last day of each _________ of the Plan Year.

o(c)   Specified dates: _________.

o(d)   No additional valuation dates.

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Trimeris, Inc. Employee 401(k) Plan

Execution Page

The Trustee (and Custodian, if applicable), by executing this Adoption Agreement, accepts its position and agrees to all of the obligations, responsibilities and duties imposed upon the Trustee (or Custodian) under the Prototype Plan and Trust. The Employer hereby agrees to the provisions of this Plan and Trust, and in witness of its agreement, the Employer by its duly authorized officers, has executed this Adoption Agreement, and the Trustee (and Custodian, if applicable) has signified its acceptance, on:  02-16-03

Name of Employer:	Trimeris, Inc.
Employer’s EIN:	56-1808663
Signed:	/s/ TIMOTHY J. CREECH /s/ Bob Bonczek
Name/Title	Timothy J. Creech, Secretary
Name/Title	Bob Bonczek, CFO/ General Counsel

Name(s) of Trustee:
	Dani P. Bolognesi
	M. Nixon Ellis
Trust EIN (Optional):
	n/a
Signed:	/s/ DANI P. BOLOGNESI
Name:	Dani P. Bolognesi
Title:	CEO/CSO
Signed:	/s/ M. NIXON ELLIS
Name:	M. Nixon Ellis
Title:	President
Signed:
Name:
Title:
Signed:
Name:
Title:
Signed:
Name:
Title:
Name of Custodian (Optional):
	n/a
Signed:
Name:
Title:

31.Plan Number. The 3-digit plan number the Employer assigns to this Plan for ERISA reporting purposes (Form 5500 Series) is:  001.

Use of Adoption Agreement. Failure to complete properly the elections in this Adoption Agreement may result in disqualification of the Employer’s Plan. The Employer only may use this Adoption Agreement in conjunction with the basic plan document referenced by its document number on Adoption Agreement page one.

Execution for Page Substitution Amendment Only. If this paragraph is completed, this Execution Page documents an amendment to Adoption Agreement Section(s) __________ effective __________________, by substitute Adoption Agreement page number(s) _________.

Prototype Plan Sponsor. The Prototype Plan Sponsor identified on the first page of the basic plan document will notify all adopting employers of any amendment of this Prototype Plan or of any abandonment or discontinuance by the Prototype Plan Sponsor of its maintenance of this Prototype Plan. For inquiries regarding the adoption of the Prototype Plan, the Prototype Plan

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Trimeris, Inc. Employee 401(k) Plan

Sponsor’s intended meaning of any Plan provisions or the effect of the opinion letter issued to the Prototype Plan Sponsor, please contact the Prototype Plan Sponsor at the following address and telephone number: P.O. Box 10096, Raleigh NC 27605, 919.783.6400.

Reliance on Sponsor Opinion Letter. The Prototype Plan Sponsor has obtained from the IRS an opinion letter specifying the form of this Adoption Agreement and the basic plan document satisfy, as of the date of the opinion letter, Code §401. An adopting Employer may rely on the Prototype Sponsor’s IRS opinion letter only to the extent provided in Announcement 2001-77, 2001-30 I.R.B. The Employer may not rely on the opinion letter in certain other circumstances or with respect to certain qualification requirements, which are specified in the opinion letter and in Announcement 2001-77. In order to have reliance in such circumstances or with respect to such qualification requirements, the Employer must apply for a determination letter to Employee Plans Determinations of the Internal Revenue Service.

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Trimeris, Inc. Employee 401(k) Plan

PARTICIPATION AGREEMENT

x Check here if not applicable and do not complete this page.

The undersigned Employer, by executing this Participation Agreement, elects to become a Participating Employer in the Plan identified in Section 1.21 of the accompanying Adoption Agreement, as if the Participating Employer were a signatory to that Adoption Agreement. The Participating Employer accepts, and agrees to be bound by, all of the elections granted under the provisions of the Prototype Plan as made by the Signatory Employer to the Execution Page of the Adoption Agreement, except as otherwise provided in this Participation Agreement.

32.EFFECTIVE DATE (1.10). The Effective Date of the Plan for the Participating Employer is: ____________________.

33.NEW PLAN/RESTATEMENT. The Participating Employer’s adoption of this Plan constitutes: (Choose one of (a) or (b))

o(a)   The adoption of a new plan by the participating Employer.

o(b)   The adoption of an amendment and restatement of plan currently maintained by the Participating Employer, identified as: _______________________________________________________________, and having an original effective date of: ____________________________________________________.

34.PREDECESSOR EMPLOYER SERVICE(1.30). In addition to the predecessor service credited by reason of Section 1.30 of the Plan, the Plan credits as Service under this Plan, service with this Participating Employer. (Choose one or more of (a) through (d) as applicable): [Note: If the Plan does not credit any additional predecessor service under Section 1.30 for this Participating Employer, do not complete this election.]

o(a)   Eligibility. For eligibility under Article II. See Plan Section 1.30 for time of Plan entry.

o(b)   Vesting. For vesting under Article V.

o(c)   Contribution allocation. For contribution allocations under Article III.

o(d)   Exceptions. Except for the following Service: _________.

Name of Plan:	Name of Participating Employer:
	Signed:
	Name:
	Title:
	Date:
	Participating Employer’s EIN: ____________________

Acceptance by the Signatory Employer to the Execution Page of the Adoption Agreement and by the Trustee.

Name of Signatory Employer:	Name(s) of Trustee:
Name:	Name:
Title:	Title:
Signed:	Signed:
Date:	Date:

[Note: Each Participating Employer must execute a separate Participation Agreement. If the Plan does not have a Participating Employer, the Signatory Employer may delete this page from the Adoption Agreement.]

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Trimeris, Inc. Employee 401(k) Plan

APPENDIX A
TESTING ELECTIONS/EFFECTIVE DATE ADDENDUM

35.The following testing elections and special effective dates apply: (Choose one or more of (a) through (n) as applicable)

o(a)   Highly Compensated Employee (1.14). For Plan Years beginning after ______, the Employer makes the following election(s) regarding the definition of Highly Compensated Employee:

(1)oTop paid group election.

(2)oCalendar year data election (fiscal year plan).

x(b)   401(k) current year testing. The Employer will apply the current year testing method in applying the ADP and ACP tests effective for Plan Years beginning after: 1996. [Note: For Plan Years beginning on or after the Employer’s execution of its “GUST” restatement, the Employer must use the same testing method within the same Plan Year for both the ADP and ACP tests.]

x(c)   Compensation. The Compensation definition under Section 1.07 will apply for Plan Years beginning after: 2001

x(d)   Election not to participate. The election not to participate under Section 2.06 is effective: on and after the date this Adoption Agreement is executed.

o(e)   401(k) safe harbor. The 401(k) safe harbor provisions under Section 3.01(d) are effective: _______.

o(f)   Negative election. The negative election provision under Section 3.02(b) is effective: _______.

x(g)   Contribution/allocation formula. The specified contribution(s) and allocation method(s) under Sections 3.01 and 3.04 are effective: for Plan Years beginning after 2001, provided that the limitation on the amount of deferrals is effective upon execution of this Adoption Agreement.

x(h)   Allocation conditions. The allocation conditions of Section 3.06 are effective: for Plan Years beginning after 1997.

o(i)   Benefit payment elections. The distribution elections of Section(s) ________are effective: ______.

o(j)   Election to continue pre-SBJPA required beginning date. A Participant may not elect to defer commencement of the distribution of his/her Vested Account Balance beyond the April 1 following the calendar year in which the Participant attains age 70 1/2. See Plan Section 6.02(A).

o(k)   Elimination of age 70 1/2 in-service distributions. The Plan eliminates a Participant’s (other than a more than 5% owner) right to receive in-service distributions on April 1 of the calendar year following the year in which the Participant attains age 70 1/2 for Plan Years beginning after: _______.

x(l)   Allocation of earnings. The earnings allocation provisions under Section 9.08 are effective: for Plan Years after 1997.

x(m)   Elimination of optional forms of benefit. The Employer elects prospectively to eliminate the following optional forms of benefit: (Choose one or more of (1), (2) and (3) as applicable)

o(1)   QJSA and QPSA benefits as described in Plan Sections 6.04, 6.05 and 6.06 effective: _____.

x(2)   Installment distributions as described in Section 6.03 effective: January 1, 2003.

o(3)   Other optional forms of benefit (Any election to eliminate must be consistent with Treas. Reg. (§)1.411(d)-4): _____________.

x(n)   Special effective date(s): The vesting schedule specified in Section 5.03 is effective on and after January 1, 1998.

For periods prior to the above-specified special effective date(s), the Plan terms in effect prior to its restatement under this Adoption Agreement will control for purposes of the designated provisions. A special effective date may not result in the delay of a Plan provision beyond the permissible effective date under any applicable law.

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Trimeris, Inc. Employee 401(k) Plan

APPENDIX B
GUST Remedial Amendment Period Elections

36.The following GUST restatement elections apply: (Choose one or more of (a) through (j) as applicable)

x(a)   Highly Compensated Employee elections. The Employer makes the following remedial amendment period elections with respect to the Highly Compensated Employee definition:

(1)	1997:	o	Top paid group election.	o	Calendar year election.
		o	Calendar year data election.
(2)	1998:	x	Top paid group election.	o	Calendar year data election.
(3)	1999:	x	Top paid group election.	o	Calendar year data election.
(4)	2000:	x	Top paid group election.	o	Calendar year data election.
(5)	2001:	x	Top paid group election.	o	Calendar year data election.
(6)	2002:	x	Top paid group election.	o	Calendar year data election.

x(b)   401(k) testing methods. The Employer makes the following remedial amendment period elections with respect to the ADP test and the ACP test: [Note: The Employer may use a different testing method for the ADP and ACP tests through the end of the Plan Year in which the Employer executes its GUST restated Plan.]

			ADP test					ACP test
(1)	1997:	o	prior year	x	current year	1997:	o	prior year	x	current year
(2)	1998:	o	prior year	x	current year	1998:	o	prior year	x	current year
(3)	1999:	o	prior year	x	current year	1999:	o	prior year	x	current year
(4)	2000:	o	prior year	x	current year	2000:	o	prior year	x	current year
(5)	2001:	o	prior year	x	current year	2001:	o	prior year	x	current year
(6)	2002:	o	prior year	x	current year	2002:	o	prior year	x	current year

o(c)   Delayed application of SBJPA required beginning date. The Employer elects to delay the effective date for the required beginning date provision of Plan Section 6.02 until Plan Years beginning after: _______.

o(d)   Model Amendment for required minimum distributions. The Employer adopts the IRS Model Amendment in Plan Section 6.02(E) effective ________. [Note: The date must not be earlier than January 1, 2001.]

Defined Benefit Limitation

o(e)   Code §415(e) repeal. The repeal of the Code §415(e) limitation is effective for Limitation Years beginning after _________. [Note: If the Employer does not make an election under (e), the repeal is effective for Limitation Years beginning after December 31, 1999.]

Code §415(e) limitation. Tothe extent necessary to satisfy the limitation under Plan Section 3.17 for Limitation Years beginning prior to the repeal of Code §415(e), the Employer will reduce: (Choose one of (f) or (g))

o(f)   The Participant’s projected annual benefit under the defined benefit plan.

o(g)   The Employer’s contribution or allocation on behalf of the Participant to the defined contribution plan and then, if necessary, the Participant’s projected annual benefit under the defined benefit plan.

Coordination with top-heavy minimum allocation. The Plan Administrator will apply the top-heavy minimum allocation provisions of Article XII with the following modifications: (Choose (h) or choose (i) or (j) or both as applicable)

o(h)   No modifications.

o(i)   For Non-Key Employees participating only in this Plan, the top-heavy minimum allocation is the minimum allocation determined by substituting ___% (not less than 4%) for “3%,” except: (Choose one of (1) or (2))

o(1)   No exceptions.

o(2)   Plan Years in which the top-heavy ratio exceeds 90%.

o(j)   For Non-Key Employees also participating in the defined benefit plan, the top-heavy minimum is: (Choose one of (1) or (2))

o(1)   5% of Compensation irrespective of the contribution rate of any Key Employee: (Choose one of a. or b.)

oa.   No exceptions.

ob.   Substituting “7 1/2%” for “5%” if the top-heavy ratio does not exceed 90%.

o(2)   0%. [Note: The defined benefit plan must satisfy the top-heavy minimum benefit requirement for these Non-Key Employees.]

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Trimeris, Inc. Employee 401(k) Plan

Actuarial assumptions for top-heavy calculation. To determine the top-heavy ratio, the Plan Administrator will use the following interest rate and mortality assumptions to value accrued benefits under a defined benefit plan: _______.

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Trimeris, Inc. Employee 401(k) Plan

CHECKLIST OF EMPLOYER INFORMATION
AND EMPLOYER ADMINISTRATIVE ELECTIONS

Commencing with the 2002 Plan Year

The Prototype Plan permits the Employer to make certain administrative elections not reflected in the Adoption Agreement. This form lists those administrative elections and provides a means of recording the Employer’s elections. This checklist is not part of the Plan document.

37.Employer Information.

Trimeris, Inc.
[Employer Name]
3518 Westgate Drive, Suite 300
[Address]
Durham, North Carolina 27707	919.419.6050
[City, State and Zip Code]	[Telephone Number]

38.Form of Business.

(a)	x	Corporation	(b)	o	S Corporation
(c)	o	Limited Liability Company	(d)	o	Sole Proprietorship
(e)	o	Partnership	(f)	o	________

39.Section 1.07(F) - Nondiscriminatory definition of Compensation. When testing nondiscrimination under the Plan, the Plan permits the Employer to make elections regarding the definition of Compensation. [Note: This election solely is for purposes of nondiscrimination testing. The election does not affect the Employer’s elections under Section 1.07 which apply for purposes of allocating Employer contributions and Participant forfeitures.]

(a)x   The Plan will “gross up” Compensation for Elective Contributions.

(b)o   The Plan will exclude Elective Contributions.

40.Section 4.04 - Rollover contributions.

(a)x   The Plan accepts rollover contributions.

(b)o   The Plan does not accept rollover contributions.

41.Section 8.06 - Participant direction of investment/404(c). The Plan authorizes Participant direction of investment with Trustee consent. If the Trustee permits Participant direction of investment, the Employer and the Trustee should adopt a policy which establishes the applicable conditions and limitations, including whether they intend the Plan to comply with ERISA §404(c).

(a)x   The Plan permits Participant direction of investment and is a 404(c) plan.

(b)o   The Plan does not permit Participant direction of investment or is a non-404(c) plan.

42.Section 9.04[A] - Participant loans. The Plan authorizes the Plan Administrator to adopt a written loan policy to permit Participant loans.

(a)x   The Plan permits Participant loans subject to the following conditions:

(1)x   Minimum loan amount: $1,000.

(2)o   Maximum number of outstanding loans: __________.

(3)x   Reasons for which a Participant may request a loan:

a.x   Any purpose.

b.o   Hardship events.

c.o   Other: ________.

(4)x   Suspension of loan repayments:

a.x   Not permitted.

b.o   Permitted for non-military leave of absence.

c.o   Permitted for military service leave of absence.

(5)x   The Participant must be a party in interest.

(b)o   The Plan does not permit Participant loans.

43.Section 11.01 - Life insurance. The Plan with Employer approval authorizes the Trustee to acquire life insurance.

(a)o   The Plan will invest in life insurance contracts.

(b)x   The Plan will not invest in life insurance contracts.

44.Surety bond company: ____________. Surety bond amount: $__________

23

EGTRRA
AMENDMENT TO THE

TRIMERIS, INC. EMPLOYEE 401(K) PLAN

EGTRRA – Sponsor Trimeris, Inc. Employee 401(k) Plan

ARTICLE I
PREAMBLE

1.1Adoption and effective date of amendment. This amendment of the plan is adopted to reflect certain provisions of the Economic Growth and Tax Relief Reconciliation Act of 2001 (“EGTRRA”). This amendment is intended as good faith compliance with the requirements of EGTRRA and is to be construed in accordance with EGTRRA and guidance issued thereunder. Except as otherwise provided, this amendment shall be effective as of the first day of the first plan year beginning after December 31, 2001.

1.2Adoption by prototype sponsor. Except as otherwise provided herein, pursuant to Section 5.01 of Revenue Procedure 2000-20 (or pursuant to the corresponding provision in Revenue Procedure 89-9 or Revenue Procedure 89-13), the sponsor hereby adopts this amendment on behalf of all adopting employers.

1.3Supersession of inconsistent provisions. This amendment shall supersede the provisions of the plan to the extent those provisions are inconsistent with the provisions of this amendment.

ARTICLE II
ADOPTION AGREEMENT ELECTIONS

The questions in this Article II only need to be completed in order to override the default provisions set forth below. If all of the default provisions will apply, then these questions should be skipped.

Unless the employer elects otherwise in this Article II, the following defaults apply:

1)The vesting schedule for matching contributions will be a 6 year graded schedule (if the plan currently has a graded schedule that does not satisfy EGTRRA) or a 3 year cliff schedule (if the plan currently has a cliff schedule that does not satisfy EGTRRA), and such schedule will apply to all matching contributions (even those made prior to 2002).

2)Rollovers are automatically excluded in determining whether the $5,000 threshold has been exceeded for automatic cash-outs (if the plan is not subject to the qualified joint and survivor annuity rules and provides for automatic cash-outs). This is applied to all participants regardless of when the distributable event occurred.

3)The suspension period after a hardship distribution is made will be 6 months and this will only apply to hardship distributions made after 2001.

4)Catch-up contributions will be allowed.

5)For target benefit plans, the increased compensation limit of $200,000 will be applied retroactively (i.e., to years prior to 2002).

2.1Vesting Schedule for Matching Contributions

If there are matching contributions subject to a vesting schedule that does not satisfy EGTRRA, then unless otherwise elected below, for participants who complete an hour of service in a plan year beginning after December 31, 2001, the following vesting schedule will apply to all matching contributions subject to a vesting schedule:

If the plan has a graded vesting schedule (i.e., the vesting schedule includes a vested percentage that is more than 0% and less than 100%) the following will apply:

Years of vesting service	Nonforfeitable percentage
2		20%
3		40%
4		60%
5		80%
6		100%

If the plan does not have a graded vesting schedule, then matching contributions will be nonforfeitable upon the completion of 3 years of vesting service.

In lieu of the above vesting schedule, the employer elects the following schedule:

a.	o	3 year cliff (a participant’s accrued benefit derived from employer matching contributions shall be nonforfeitable upon the participant’s completion of three years of vesting service).
b.	o	6 year graded schedule (20% after 2 years of vesting service and an additional 20% for each year thereafter).
c.	o	Other (must be at least as liberal as a. or the b. above):

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EGTRRA – Sponsor Trimeris, Inc. Employee 401(k) Plan

Years of vesting service	Nonforfeitable percentage
___________ ___________ ___________ ___________ ___________	__________% __________% __________% __________% __________%

The vesting schedule set forth herein shall only apply to participants who complete an hour of service in a plan year beginning after December 31, 2001, and, unless the option below is elected, shall apply to all matching contributions subject to a vesting schedule.

d. o The vesting schedule will only apply to matching contributions made in plan years beginning after December 31, 2001 (the prior schedule will apply to matching contributions made in prior plan years).

2.2Exclusion of Rollovers in Application of Involuntary Cash-out Provisions (for profit sharing and 401(k) plans only). If the plan is not subject to the qualified joint and survivor annuity rules and includes involuntary cash-out provisions, then unless one of the options below is elected, effective for distributions made after December 31, 2001, rollover contributions will be excluded in determining the value of the participant’s nonforfeitable account balance for purposes of the plan’s involuntary cash-out rules.

a.	o	Rollover contributions will not be excluded.
b.	o	Rollover contributions will be excluded only with respect to distributions made after ______________. (Enter a date no earlier than December 31, 2001.)
c.	o	Rollover contributions will only be excluded with respect to participants who separated from service after ______________. (Enter a date. The date may be earlier than December 31, 2001.)

2.3Suspension period of hardship distributions. If the plan provides for hardship distributions upon satisfaction of the safe harbor (deemed) standards as set forth in Treas. Reg. Section 1.401(k)-1(d)(2)(iv), then, unless the option below is elected, the suspension period following a hardship distribution shall only apply to hardship distributions made after December 31, 2001.

o With regard to hardship distributions made during 2001, a participant shall be prohibited from making elective deferrals and employee contributions under this and all other plans until the later of January 1, 2002, or 6 months after receipt of the distribution.

2.4Catch-up contributions (for 401(k) profit sharing plans only): The plan permits catch-up contributions (Article VI) unless the option below is elected.

oThe plan does not permit catch-up contributions to be made.

2.5For target benefit plans only: The increased compensation limit ($200,000 limit) shall apply to years prior to 2002 unless the option below is elected.

oThe increased compensation limit will not apply to years prior to 2002.

ARTICLE III
VESTING OF MATCHING CONTRIBUTIONS

3.1Applicability. This Article shall apply to participants who complete an Hour of Service after December 31, 2001, with respect to accrued benefits derived from employer matching contributions made in plan years beginning after December 31, 2001. Unless otherwise elected by the employer in Section 2.1 above, this Article shall also apply to all such participants with respect to accrued benefits derived from employer matching contributions made in plan years beginning prior to January 1, 2002.

3.2Vesting schedule. A participant’s accrued benefit derived from employer matching contributions shall vest as provided in Section 2.1 of this amendment.

ARTICLE IV
INVOLUNTARY CASH-OUTS

4.1Applicability and effective date. If the plan provides for involuntary cash-outs of amounts less than $5,000, then unless otherwise elected in Section 2.2 of this amendment, this Article shall apply for distributions made after December 31, 2001, and shall apply to all participants. However, regardless of the preceding, this Article shall not apply if the plan is subject to the qualified joint and survivor annuity requirements of Sections 401(a)(11) and 417 of the Code.

4.2Rollovers disregarded in determining value of account balance for involuntary distributions. For purposes of the Sections of the plan that provide for the involuntary distribution of vested accrued benefits of $5,000 or less, the value of a participant’s nonforfeitable account balance shall be determined without regard to that portion of the account

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EGTRRA – Sponsor Trimeris, Inc. Employee 401(k) Plan

balance that is attributable to rollover contributions (and earnings allocable thereto) within the meaning of Sections 402(c), 403(a)(4), 403(b)(8), 408(d)(3)(A)(ii), and 457(e)(16) of the Code. If the value of the participant’s nonforfeitable account balance as so determined is $5,000 or less, then the plan shall immediately distribute the participant’s entire nonforfeitable account balance.

ARTICLE V
HARDSHIP DISTRIBUTIONS

5.1Applicability and effective date. If the plan provides for hardship distributions upon satisfaction of the safe harbor (deemed) standards as set forth in Treas. Reg. Section 1.401(k)-1(d)(2)(iv), then this Article shall apply for calendar years beginning after 2001.

5.2Suspension period following hardship distribution. A participant who receives a distribution of elective deferrals after December 31, 2001, on account of hardship shall be prohibited from making elective deferrals and employee contributions under this and all other plans of the employer for 6 months after receipt of the distribution. Furthermore, if elected by the employer in Section 2.3 of this amendment, a participant who receives a distribution of elective deferrals in calendar year 2001 on account of hardship shall be prohibited from making elective deferrals and employee contributions under this and all other plans until the later of January 1, 2002, or 6 months after receipt of the distribution.

ARTICLE VI
CATCH-UP CONTRIBUTIONS

Catch-up Contributions. Unless otherwise elected in Section 2.4 of this amendment, all employees who are eligible to make elective deferrals under this plan and who have attained age 50 before the close of the plan year shall be eligible to make catch-up contributions in accordance with, and subject to the limitations of, Section 414(v) of the Code. Such catch-up contributions shall not be taken into account for purposes of the provisions of the plan implementing the required limitations of Sections 402(g) and 415 of the Code. The plan shall not be treated as failing to satisfy the provisions of the plan implementing the requirements of Section 401(k)(3), 401(k)(l 1), 401(k)(12), 410(b), or 416 of the Code, as applicable, by reason of the making of such catch-up contributions.

ARTICLE VII
INCREASE IN COMPENSATION LIMIT

Increase in Compensation Limit. The annual compensation of each participant taken into account in determining allocations for any plan year beginning after December 31, 2001, shall not exceed $200,000, as adjusted for cost-of-living increases in accordance with Section 401(a)(17)(B) of the Code. Annual compensation means compensation during the plan year or such other consecutive 12-month period over which compensation is otherwise determined under the plan (the determination period). If this is a target benefit plan, then except as otherwise elected in Section 2.5 of this amendment, for purposes of determining benefit accruals in a plan year beginning after December 31, 2001, compensation for any prior determination period shall be limited to $200,000. The cost-of-living adjustment in effect for a calendar year applies to annual compensation for the determination period that begins with or within such calendar year.

ARTICLE VIII
PLAN LOANS

Plan loans for owner-employees or shareholder-employees. If the plan permits loans to be made to participants, then effective for plan loans made after December 31, 2001, plan provisions prohibiting loans to any owner-employee or shareholder-employee shall cease to apply.

ARTICLE IX
LIMITATIONS ON CONTRIBUTIONS (IRC SECTION 415 LIMITS)

9.1Effective date. This Section shall be effective for limitation years beginning after December 31, 2001.

9.2Maximum annual addition. Except to the extent permitted under Article VI of this amendment and Section 414(v) of the Code, if applicable, the annual addition that may be contributed or allocated to a participant’s account under the plan for any limitation year shall not exceed the lesser of:

a.$40,000, as adjusted for increases in the cost-of-living under Section 415(d) of the Code, or

b.100 percent of the participant’s compensation, within the meaning of Section 415(c)(3) of the Code, for the limitation year.

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EGTRRA - Sponsor Trimeris, Inc. Employee 401(k) Plan

The compensation limit referred to in b. shall not apply to any contribution for medical benefits after separation from service (within the meaning of Section 401(h) or Section 419A(f)(2) of the Code) which is otherwise treated as an annual addition.

ARTICLE X
MODIFICATION OF TOP-HEAVY RULES

10.1Effective date. This Article shall apply for purposes of determining whether the plan is a top-heavy plan under Section 416(g) of the Code for plan years beginning after December 31, 2001, and whether the plan satisfies the minimum benefits requirements of Section 416(c) of the Code for such years. This Article amends the top-heavy provisions of the plan.

10.2Determination of top-heavy status.

10.2.1Key employee. Key employee means any employee or former employee (including any deceased employee) who at any time during the plan year that includes the determination date was an officer of the employer having annual compensation greater than $130,000 (as adjusted under Section 416(i)(1) of the Code for plan years beginning after December 31, 2002), a 5-percent owner of the employer, or a 1-percent owner of the employer having annual compensation of more than $150,000. For this purpose, annual compensation means compensation within the meaning of Section 415(c)(3) of the Code. The determination of who is a key employee will be made in accordance with Section 416(i)(1) of the Code and the applicable regulations and other guidance of general applicability issued thereunder.

10.2.2Determination of present values and amounts. This Section 10.2.2 shall apply for purposes of determining the present values of accrued benefits and the amounts of account balances of employees as of the determination date.

a.Distributions during year ending on the determination date. The present values of accrued benefits and the amounts of account balances of an employee as of the determination date shall be increased by the distributions made with respect to the employee under the plan and any plan aggregated with the plan under Section 416(g)(2) of the Code during the 1-year period ending on the determination date. The preceding sentence shall also apply to distributions under a terminated plan which, had it not been terminated, would have been aggregated with the plan under Section 416(g)(2)(A)(i) of the Code. In the case of a distribution made for a reason other than separation from service, death, or disability, this provision shall be applied by substituting “5-year period” for “1-year period.”

b.Employees not performing services during year ending on the determination date. The accrued benefits and accounts of any individual who has not performed services for the employer during the 1-year period ending on the determination date shall not be taken into account.

10.3Minimum benefits.

10.3.1Matching contributions. Employer matching contributions shall be taken into account for purposes of satisfying the minimum contribution requirements of Section 416(c)(2) of the Code and the plan. The preceding sentence shall apply with respect to matching contributions under the plan or, if the plan provides that the minimum contribution requirement shall be met in another plan, such other plan. Employer matching contributions that are used to satisfy the minimum contribution requirements shall be treated as matching contributions for purposes of the actual contribution percentage test and other requirements of Section 401(m) of the Code.

10.3.2Contributions under other plans. The employer may provide, in an addendum to this amendment, that the minimum benefit requirement shall be met in another plan (including another plan that consists solely of a cash or deferred arrangement which meets the requirements of Section 401(k)(12) of the Code and matching contributions with respect to which the requirements of Section 401(m)(11) of the Code are met). The addendum should include the name of the other plan, the minimum benefit that will be provided under such other plan, and the employees who will receive the minimum benefit under such other plan.

ARTICLE XI
DIRECT ROLLOVERS

11.1Effective date. This Article shall apply to distributions made after December 31, 2001.

11.2Modification of definition of eligible retirement plan. For purposes of the direct rollover provisions of the plan, an eligible retirement plan shall also mean an annuity contract described in Section 403(b) of the Code and an eligible plan under Section 457(b) of the Code which is maintained by a state, political subdivision of a state, or any agency or instrumentality of a state or political subdivision of a state and which agrees to separately account for amounts transferred into such plan from this plan. The definition of eligible retirement plan shall also apply in the case of a distribution to a surviving spouse, or to a spouse or former spouse who is the alternate payee under a qualified domestic

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EGTRRA – Sponsor Trimeris, Inc. Employee 401(k) Plan

relation order, as defined in Section 414(p) of the Code.

11.3Modification of definition of eligible rollover distribution to exclude hardship distributions. For purposes of the direct rollover provisions of the plan, any amount that is distributed on account of hardship shall not be an eligible rollover distribution and the distributee may not elect to have any portion of such a distribution paid directly to an eligible retirement plan.

11.4Modification of definition of eligible rollover distribution to include after-tax employee contributions. For purposes of the direct rollover provisions in the plan, a portion of a distribution shall not fail to be an eligible rollover distribution merely because the portion consists of after-tax employee contributions which are not includible in gross income. However, such portion may be transferred only to an individual retirement account or annuity described in Section 408(a) or (b) of the Code, or to a qualified defined contribution plan described in Section 401(a) or 403(a) of the Code that agrees to separately account for amounts so transferred, including separately accounting for the portion of such distribution which is includible in gross income and the portion of such distribution which is not so includible.

ARTICLE XII
ROLLOVERS FROM OTHER PLANS

Rollovers from other plans. The employer, operationally and on a nondiscriminatory basis, may limit the source of rollover contributions that may be accepted by this plan.

ARTICLE XIII
REPEAL OF MULTIPLE USE TEST

Repeal of Multiple Use Test. The multiple use test described in Treasury Regulation Section 1.401(m)-2 and the plan shall not apply for plan years beginning after December 31, 2001.

ARTICLE XIV
ELECTIVE DEFERRALS

14.1Elective Deferrals - Contribution Limitation. No participant shall be permitted to have elective deferrals made under this plan, or any other qualified plan maintained by the employer during any taxable year, in excess of the dollar limitation contained in Section 402(g) of the Code in effect for such taxable year, except to the extent permitted under Article VI of this amendment and Section 414(v) of the Code, if applicable.

14.2Maximum Salary Reduction Contributions for SIMPLE plans. If this is a SIMPLE 401(k) plan, then except to the extent permitted under Article VI of this amendment and Section 414(v) of the Code, if applicable, the maximum salary reduction contribution that can be made to this plan is the amount determined under Section 408(p)(2)(A)(ii) of the Code for the calendar year.

ARTICLE XV
SAFE HARBOR PLAN PROVISIONS

Modification of Top-Heavy Rules. The top-heavy requirements of Section 416 of the Code and the plan shall not apply in any year beginning after December 31, 2001, in which the plan consists solely of a cash or deferred arrangement which meets the requirements of Section 401(k)(12) of the Code and matching contributions with respect to which the requirements of Section 401(m)(11) of the Code are met.

ARTICLE XVI
DISTRIBUTION UPON SEVERANCE OF EMPLOYMENT

16.1Effective date. This Article shall apply for distributions and transactions made after December 31, 2001, regardless of when the severance of employment occurred.

16.2New distributable event. A participant’s elective deferrals, qualified nonelective contributions, qualified matching contributions, and earnings attributable to these contributions shall be distributed on account of the participant’s severance from employment. However, such a distribution shall be subject to the other provisions of the plan regarding distributions, other than provisions that require a separation from service before such amounts may be distributed.

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EGTRRA – Sponsor Trimeris, Inc. Employee 401(k) Plan

Except with respect to any election made by the employer in Article II, this amendment is hereby adopted by the prototype sponsor on behalf of all adopting employers on:

[Sponsor’s signature and Adoption Date are on file with Sponsor]

NOTE: The employer only needs to execute this amendment if an election has been made in Article II of this amendment.

This amendment has been executed this _________ day of _______________________, _______.

Name of Employer:  Trimeris, Inc.
By:
	EMPLOYER

Name of Plan: Trimeris, Inc. Employee 401(k) Plan

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