SC 13G/A 1 amylin-13ga2.txt -------------------------- OMB APPROVAL -------------------------- OMB Number: 3235-0145 Expires: December 31, 2005 Estimated average burden hours per response......11 -------------------------- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)1 Amylin Pharmaceuticals, Inc. -------------------------------------------------------------------------------- (Name of Issuer) Common Stock, par value $0.001 per share -------------------------------------------------------------------------------- (Title of Class of Securities) 032346108 -------------------------------------------------------------------------------- (CUSIP Number) December 31, 2004 -------------------------------------------------------------------------------- (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: |_| Rule 13d-1(b) |X| Rule 13d-1(c) |_| Rule 13d-1(d) -------- 1 The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). (Continued on following pages) Page 1 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Farallon Capital Partners, L.P. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, is a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 California ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 1,321,800 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 1,321,800 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 1,321,800 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 1.3% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 PN ------------==================================================================== Page 2 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Farallon Capital Institutional Partners, L.P. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, is a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 California ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 1,261,500 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 1,261,500 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 1,261,500 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 1.2% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 PN ------------==================================================================== Page 3 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Farallon Capital Institutional Partners II, L.P. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, is a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 California ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 141,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 141,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 141,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 0.1% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 PN ------------==================================================================== Page 4 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Farallon Capital Institutional Partners III, L.P. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, is a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 Delaware ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 150,600 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 150,600 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 150,600 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 0.1% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 PN ------------==================================================================== Page 5 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Tinicum Partners, L.P. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, is a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 New York ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 54,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 54,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 54,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 0.1% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 PN ------------==================================================================== Page 6 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Farallon Capital Management, L.L.C. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 Delaware ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 2,682,100 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 2,682,100 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 2,682,100 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 2.6% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IA, OO ------------==================================================================== Page 7 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Farallon Partners, L.L.C. ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 Delaware ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 2,928,900 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 2,928,900 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 2,928,900 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 2.8% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 OO ------------==================================================================== Page 8 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) David I. Cohen [see Preliminary Note] ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY -0- ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 -0- ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 -0- ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 0% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 9 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Chun R. Ding ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 10 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Joseph F. Downes ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 11 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) William F. Duhamel ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 12 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Charles E. Ellwein ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 13 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Richard B. Fried ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 14 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Monica R. Landry ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 15 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) William F. Mellin ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 16 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Stephen L. Millham ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 17 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Rajiv A. Patel ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 18 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Derek C. Schrier ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 19 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Thomas F. Steyer ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 20 of 27 Pages 13G =================== CUSIP No. 032346108 =================== ------------==================================================================== NAMES OF REPORTING PERSONS 1 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Mark C. Wehrly ------------==================================================================== CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) (a) [ ] (b) [ X ]** 2 ** The reporting persons making this filing hold an aggregate of 5,611,000 Shares, which is 5.4% of the class of securities. The reporting person on this cover page, however, may be deemed a beneficial owner only of the securities reported by it on this cover page. ------------==================================================================== 3 SEC USE ONLY ------------==================================================================== CITIZENSHIP OR PLACE OF ORGANIZATION 4 United States ------------==================================================================== SOLE VOTING POWER 5 NUMBER OF -0- ------------=========================================== SHARES SHARED VOTING POWER BENEFICIALLY 6 OWNED BY 5,611,000 ------------=========================================== EACH SOLE DISPOSITIVE POWER 7 REPORTING -0- PERSON WITH ------------=========================================== SHARED DISPOSITIVE POWER 8 5,611,000 ------------==================================================================== AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 9 5,611,000 ------------==================================================================== CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES 10 CERTAIN SHARES (See Instructions) [ ] ------------==================================================================== PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 11 5.4% ------------==================================================================== TYPE OF REPORTING PERSON (See Instructions) 12 IN ------------==================================================================== Page 21 of 27 Pages This Amendment No. 1 to Schedule 13G amends the Schedule 13G initially filed on August 2, 2004 (collectively, with all amendments thereto, the "Schedule 13G"). Preliminary Note: Effective as of January 1, 2005, each of Noonday G.P. (U.S.), L.L.C. (the "First Noonday Sub-adviser") and Noonday Asset Management, L.P. (the "Second Noonday Sub-adviser") entered into an investment subadvisory agreement with the Management Company and the General Partner, under which the First Noonday Sub-adviser and the Second Noonday Sub-adviser are granted investment authority over certain securities and instruments owned by the Partnerships and Managed Accounts. Noonday Capital, L.L.C. serves as the general partner of the Second Noonday Sub-adviser. David I. Cohen serves as the managing member of the First Noonday Sub-adviser and Noonday Capital, L.L.C. Mr. Cohen resigned as a managing member of the Management Company and the General Partner effective December 31, 2004. This amendment to the Schedule 13G reports that Mr. Cohen is no longer the deemed beneficial owner of any of the Shares reported herein. Item 1. Issuer ------ (a) Name of Issuer: -------------- Amylin Pharmaceuticals, Inc. (the "Company") (b) Address of Issuer's Principal Executive Offices: ----------------------------------------------- 9360 Towne Centre Drive, Suite 110, San Diego, California 92121 Item 2. Identity And Background ----------------------- Title Of Class Of Securities And CUSIP Number (Item 2(d) and (e)) ---------------------------------------------------------------- This statement relates to shares of Common Stock, par value $0.001 per share (the "Shares"), of the Company. The CUSIP number of the Shares is 032346108. Page 22 of 27 Pages Name Of Persons Filing, Address Of Principal Business Office And ---------------------------------------------------------------- Citizenship (Item 2(a), (b) and (c)) ------------------------------------ This statement is filed by the entities and persons listed below, all of whom together are referred to herein as the "Reporting Persons." The Partnerships ---------------- (i) Farallon Capital Partners, L.P., a California limited partnership ("FCP"), with respect to the Shares held by it; (ii) Farallon Capital Institutional Partners, L.P., a California limited partnership ("FCIP"), with respect to the Shares held by it; (iii) Farallon Capital Institutional Partners II, L.P., a California limited partnership ("FCIP II"), with respect to the Shares held by it; (iv) Farallon Capital Institutional Partners III, L.P., a Delaware limited partnership ("FCIP III"), with respect to the Shares held by it; and (v) Tinicum Partners, L.P., a New York limited partnership ("Tinicum"), with respect to the Shares held by it. FCP, FCIP, FCIP II, FCIP III and Tinicum are together referred to herein as the "Partnerships." The Management Company ---------------------- (vi) Farallon Capital Management, L.L.C., a Delaware limited liability company (the "Management Company"), with respect to the Shares held by certain accounts managed by the Management Company (the "Managed Accounts"). The General Partner Of The Partnerships --------------------------------------- (vii) Farallon Partners, L.L.C., a Delaware limited liability company which is the general partner of each of the Partnerships (the "General Partner"), with respect to the Shares held by each of the Partnerships. The Managing Members Of The General Partner And The Management Company ---------------------------------------------------------------------- (viii) The following persons who are (or, solely with respect to David I. Cohen, were) managing members of both the General Partner and the Management Company, with respect to the Shares held by the Partnerships and the Managed Accounts: David I. Cohen ("Cohen"), Chun R. Ding ("Ding"), Joseph F. Downes ("Downes"), William F. Duhamel ("Duhamel"), Charles E. Ellwein ("Ellwein"), Richard B. Fried ("Fried"), Monica R. Landry Page 23 of 27 Pages ("Landry"), William F. Mellin ("Mellin"), Stephen L. Millham ("Millham"), Rajiv A. Patel ("Patel"), Derek C. Schrier ("Schrier"), Thomas F. Steyer ("Steyer") and Mark C. Wehrly ("Wehrly"). Cohen, Ding, Downes, Duhamel, Ellwein, Fried, Landry, Mellin, Millham, Patel, Schrier, Steyer and Wehrly are together referred to herein as the "Individual Reporting Persons." The citizenship of each of the Partnerships, the General Partner and the Management Company is set forth above. Each of the Individual Reporting Persons is a United States citizen. The address of the principal business office of each of the Reporting Persons other than Cohen is c/o Farallon Capital Management, L.L.C., One Maritime Plaza, Suite 1325, San Francisco, California 94111. The address of the principal business office of Cohen is c/o Noonday Asset Management, L.P., 227 West Trade Street, Suite 2140, Charlotte, North Carolina 28202. Item 3. If This Statement Is Filed Pursuant To Sections 240.13d-1(b), Or ---------------------------------------------------------------- 13d-2(b) Or (c), Check Whether The Person Filing Is An Entity Specified ----------------------------------------------------------------------- In (a) - (j): ------------- Not Applicable. If This Statement Is Filed Pursuant To Section 240.13d-1(c), Check This ----------------------------------------------------------------------- Box. [X] ---- Item 4. Ownership --------- The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person hereto is incorporated herein by reference for each such Reporting Person. The Shares reported hereby for the Partnerships are owned directly by the Partnerships and those reported by the Management Company on behalf of the Managed Accounts are owned directly by the Managed Accounts. The General Partner, as general partner to the Partnerships, may be deemed to be the beneficial owner of all such Shares owned by the Partnerships. The Management Company, as investment adviser to the Managed Accounts, may be deemed to be the beneficial owner of all such Shares owned by the Managed Accounts. The Individual Reporting Persons other than Cohen, as managing members of both the General Partner and the Management Company, may each be deemed to be the beneficial owner of all such Shares held by the Partnerships and the Managed Accounts. Each of the Management Company, the General Partner and the Individual Reporting Persons hereby disclaims any beneficial ownership of any such Shares. Item 5. Ownership Of Five Percent Or Less Of A Class -------------------------------------------- As of December 31, 2004, Cohen may no longer be deemed to be the beneficial owner of any Shares. Item 6. Ownership Of More Than Five Percent On Behalf Of Another Person --------------------------------------------------------------- Not Applicable. Page 24 of 27 Pages Item 7. Identification And Classification Of The Subsidiary Which Acquired The ---------------------------------------------------------------------- Security Being Reported On By The Parent Holding Company -------------------------------------------------------- Not Applicable. Item 8. Identification And Classification Of Members Of The Group --------------------------------------------------------- The Reporting Persons are filing this Schedule 13G pursuant to Rule 13d-1(c). Consistent with Item 2 of the cover page for each Reporting Person above, the Reporting Persons neither disclaim nor affirm the existence of a group among them. Item 9. Notice Of Dissolution Of Group ------------------------------ Not Applicable. Item 10. Certification ------------- By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. Page 25 of 27 Pages SIGNATURES ---------- After reasonable inquiry and to the best of our knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. Dated: January 28, 2005 /s/ Joseph F. Downes ---------------------------------------- FARALLON PARTNERS, L.L.C., on its own behalf and as General Partner of FARALLON CAPITAL PARTNERS, L.P., FARALLON CAPITAL INSTITUTIONAL PARTNERS, L.P., FARALLON CAPITAL INSTITUTIONAL PARTNERS II, L.P., FARALLON CAPITAL INSTITUTIONAL PARTNERS III, L.P., And TINICUM PARTNERS, L.P., By Joseph F. Downes Managing Member /s/ Joseph F. Downes ---------------------------------------- FARALLON CAPITAL MANAGEMENT, L.L.C., By Joseph F. Downes Managing Member /s/ Joseph F. Downes ---------------------------------------- Joseph F. Downes, individually and as attorney-in-fact for each of David I. Cohen, Chun R. Ding, William F. Duhamel, Charles E. Ellwein, Richard B. Fried, Monica R. Landry, William F. Mellin, Stephen L. Millham, Rajiv A. Patel, Derek C. Schrier, Thomas F. Steyer and Mark C. Wehrly. The Powers of Attorney, each executed by Cohen, Mellin, Millham and Steyer authorizing Downes to sign and file this Schedule 13G on each person's behalf, which were filed with Amendment No. 1 to the Schedule 13D filed with the Securities and Exchange Commission on January 20, 1998, by such Reporting Persons with respect to the Units of Spiros Development Corporation II, Inc., are hereby incorporated by reference. The Powers of Attorney, each executed by Duhamel and Fried authorizing Downes to sign and file this Schedule 13G on each person's behalf, which were filed with Amendment No. 7 to the Schedule 13D filed with the Securities and Exchange Commission on February 9, 1999 by such Reporting Persons with respect to the Callable Class A Common Stock of Crescendo Pharmaceuticals Corporation, are hereby incorporated by reference. The Power of Attorney executed by Mark C. Wehrly authorizing Downes to sign and file this Schedule 13G on his behalf, which was filed with Page 26 of 27 Pages Amendment No. 4 to the Schedule 13D filed with the Securities and Exchange Commission on January 18, 2000, by such Reporting Person with respect to the Class A Common Stock of Momentum Business Applications, Inc., is hereby incorporated by reference. The Power of Attorney executed by Monica R. Landry authorizing Downes, as well as Steyer and Cohen, to sign and file this Schedule 13G on her behalf, which was filed with the Schedule 13G filed with the Securities and Exchange Commission on January 22, 2001, by such Reporting Person with respect to the Common Stock of Korn/Ferry International is hereby incorporated by reference. The Powers of Attorney executed by each of Chun R. Ding and Derek C. Schrier authorizing Downes to sign and file this Schedule 13G on his behalf, which was filed with Amendment No. 1 to the Schedule 13D filed with the Securities and Exchange Commission on July 2, 2003, by such Reporting Person with respect to the Common Stock of Salix Pharmaceuticals, Ltd., is hereby incorporated by reference. The Powers of Attorney executed by each of Charles E. Ellwein and Rajiv A. Patel authorizing Downes to sign and file this Schedule 13G on his behalf, which was filed with Amendment No. 4 to the Schedule 13G filed with the Securities and Exchange Commission on January 8, 2004 by such Reporting Person with respect to the Common Stock of Catalytica Energy Systems, Inc., is hereby incorporated by reference. Page 27 of 27 Pages