-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 MXkH4HzcuQNQQa2Ep3jmj8JiHKeMbhd2w+sGDrOuzQ/SJknjMok9cRV4KAtbzjAM
 ticz+B5Ov7B/17uQYDer5Q==

<SEC-DOCUMENT>0000909450-07-000001.txt : 20070104
<SEC-HEADER>0000909450-07-000001.hdr.sgml : 20070104
<ACCEPTANCE-DATETIME>20070104215205
ACCESSION NUMBER:		0000909450-07-000001
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20070104
FILED AS OF DATE:		20070104
DATE AS OF CHANGE:		20070104

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VAXGEN INC
		CENTRAL INDEX KEY:			0001036968
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943236309
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1000 MARINA BLVD
		STREET 2:		STE 200
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005
		BUSINESS PHONE:		6506241000

	MAIL ADDRESS:	
		STREET 1:		1000 MARINA BLVD
		STREET 2:		STE 200
		CITY:			BRISBANE
		STATE:			CA
		ZIP:			94005

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GRUBER & MCBAINE CAPITAL MANAGEMENT LLC
		CENTRAL INDEX KEY:			0000909450

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-26483
		FILM NUMBER:		07511797

	BUSINESS ADDRESS:	
		STREET 1:		50 OSGOOD PLACE PENTHOUSE
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94133
		BUSINESS PHONE:		4159811039

	MAIL ADDRESS:	
		STREET 1:		50 OSGOOD PLACE
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94133

	FORMER NAME:	
		FORMER CONFORMED NAME:	GRUBER & MCBAINE CAPITAL MANAGEMENT/GRUBER JON D ET AL
		DATE OF NAME CHANGE:	19951108
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2007-01-04</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001036968</issuerCik>
        <issuerName>VAXGEN INC</issuerName>
        <issuerTradingSymbol>VXGN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000909450</rptOwnerCik>
            <rptOwnerName>GRUBER &amp; MCBAINE CAPITAL MANAGEMENT LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>50 OSGOOD PLACE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94133</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>313000</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>375569</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2020350</value>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Limited Partnership and Investment Advisory Accounts</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This form is filed by Gruber &amp; McBaine Capital Management, LLC (GMCM), a limited liability company that is an investment adviser for client accounts and a general partner of investment limited partnerships; Jon D. Gruber (Gruber) and J. Patterson McBaine (McBaine), who are managers, members and portfolio managers of GMCM; Eric B Swergold (Swergold) ho is a member and portfolio manager of GMCM who is a member and portfolio advisor of GMCM.</footnote>
        <footnote id="F2">By Gruber.</footnote>
        <footnote id="F3">By McBaine.</footnote>
        <footnote id="F4">This total is the number of shares beneficially owned after the transactions reported in accounts and investment partnerships in which the reporting persons have some pecuniary interest; the total excludes shares held in other client accounts managed by GMCM in which the reporting persons have no pecuniary interest.</footnote>
        <footnote id="F5">Each such reporting person disclaims beneficial ownership of the securities with respect to which indirect beneficial ownership is reported, except to the extent of that reporting persons pro rata pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>GRUBER &amp; MCBAINE CAPITAL MANAGEMENT, LLC  By:	/s/ J. Patterson McBaine, J. Patterson McBaine, Manager</signatureName>
        <signatureDate>2007-01-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Jon D. Gruber</signatureName>
        <signatureDate>2007-01-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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