-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 FGnUq3y+xQm+4zyCzXaVyw==

<SEC-DOCUMENT>0001209191-10-018860.txt : 20100326
<SEC-HEADER>0001209191-10-018860.hdr.sgml : 20100326
<ACCEPTANCE-DATETIME>20100326135252
ACCESSION NUMBER:		0001209191-10-018860
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100326
DATE AS OF CHANGE:		20100326
EFFECTIVENESS DATE:		20100326

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OXIGENE INC
		CENTRAL INDEX KEY:			0000908259
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				133679168
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-90825-9N
		FILM NUMBER:		10707081

	BUSINESS ADDRESS:	
		STREET 1:		701 GATEWAY BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-635-7000

	MAIL ADDRESS:	
		STREET 1:		701 GATEWAY BLVD.
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000908259</cik>
        <entityName>OXIGENE INC</entityName>
        <issuerAddress>
            <street1>701 Gateway Boulevard, Suite 210</street1>
            <city>South San Francisco</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94080</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>0</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName>J.</middleName>
                <lastName>Langecker</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>N.</middleName>
                <lastName>Shiebler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>B.</middleName>
                <lastName>Murphy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Roy</firstName>
                <middleName>H.</middleName>
                <lastName>Fickling</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>D.</middleName>
                <lastName>Schwieterman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <lastName>Kessel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alastair</firstName>
                <middleName>J.J.</middleName>
                <lastName>Wood</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Chaplin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>701 Gateway Boulevard, Suite 210</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-12</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>ROTH Capital Partners, LLC</recipientName>
                <recipientCRDNumber>15407</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>24 Corporate Plaza-200</street1>
                    <city>Newport Beach</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>92660</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>7500000</totalOfferingAmount>
            <totalAmountSold>7500000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>450000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>OXiGENE Inc</issuerName>
                <signatureName>Peter J. Langecker</signatureName>
                <nameOfSigner>Peter J. Langecker</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2010-03-26</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----