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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
9 Months Ended 12 Months Ended
Sep. 30, 2011
Sep. 30, 2010
Dec. 31, 2010
Dec. 31, 2009
Dec. 31, 2008
Operating activities:          
Net loss $ (7,308) $ (22,027) $ (23,770) $ (24,728) $ (21,401)
Loss attributed to non controlling interests       (4,215) (520)
Adjustments to reconcile net loss to net cash used in operating activities:          
Change in fair value of warrants and other financial instruments (2,219) 6,987 6,018 (2,166) (3,335)
Depreciation 44 77 96 123 133
Amortization of license agreement 73 73 98 97 98
Rent loss accrual       (60) (163)
Stock-based compensation 550 650 952 778 1,086
Changes in operating assets and liabilities:          
Restricted cash 55 65 65 (140)  
Prepaid expenses and other current assets 62 232 457 (210) (78)
Accounts payable, accrued expenses and other payables (234) (4,000) (4,343) 1,852 782
Net cash used in operating activities (8,977) (17,943) (20,427) (28,669) (23,398)
Investing activities:          
Proceeds from sale of available-for-sale securities       753 23,456
Purchase of available-for-sale securities         (4,314)
Proceeds from sale of marketable securities held by Symphony ViDA, Inc       2,286 (14,663)
Purchase of furniture, fixtures and equipment       (109) (113)
Proceeds from sale of fixed assets       4  
Changes in other assets   40 3   137
Net cash provided by investing activities   40 3 2,934 4,503
Financing activities:          
Proceeds from issuance of common stock, net of acquisition costs 17,019 10,380 11,044 9,029 14,691
Proceeds from Symphony ViDA acquisition, net of acquisition costs       12,289  
Proceeds from purchase of noncontrolling interest by shareholders in Symphony ViDA, Inc., net of fees         13,952
Proceeds from exercise of employee stock plans   45 50 74  
Net cash provided by financing activities 17,019 10,425 11,094 21,392 28,643
(Decrease) increase in cash and cash equivalents 8,042 (7,478) (9,330) (4,343) 9,748
Cash and cash equivalents at beginning of period 4,602 13,932 13,932 18,275 8,527
Cash and cash equivalents at end of period 12,644 6,454 4,602 13,932 18,275
Non- cash Disclosures:          
Fair market value of stock issued in exchange for warrants 5,381        
Fair market value reclassification of CEFF warrants to equity in connection with warrant exchange 3        
Fair market value of private placement warrants at issuance   11,868 11,868 4,055 6,111
Fair market value reclassification of CEFF warrants to liabilities in connection with private placement   103 103 155  
Fair market value of warrants at exercise   5,043 7,645    
Stock issued as consideration for Symphony ViDA, Inc. purchase options         $ 4,000