Share-based Compensation (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		147 Months Ended
	Mar. 31, 2014	Mar. 31, 2013	Mar. 31, 2014
Non-cash, share-based compensation expense
Total expenses	$ 158	$ 42	$ 3,029
Research and Development
Non-cash, share-based compensation expense
Total expenses	40	15	707
Selling, General and Administrative
Non-cash, share-based compensation expense
Total expenses	118	27	1,935
Restructuring Expense
Non-cash, share-based compensation expense
Total expenses			$ 387