Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 106,752	$ 194,905
Short-term investments	1,281,913	1,140,445
Accounts receivable	42,894	43,213
Inventory	11,778	11,381
Advance payments to contract manufacturers	27,425	26,450
Other current assets	19,352	21,293
Total current assets	1,490,114	1,437,687
Long-term investments	455,867	582,889
Property, plant and equipment, net	58,158	48,851
Operating lease right-of-use assets	83,475
Goodwill	76,501	76,501
Other assets	2,367	4,244
Total assets	2,166,482	2,150,172
Current liabilities:
Accounts payable	11,012	5,854
Accrued compensation	18,371	9,937
Accrued contract manufacturing expenses	21,384	23,841
Accrued clinical trial expenses	17,496	14,700
Other accrued expenses	14,624	9,580
Interest payable	4,090	4,198
Operating lease liabilities, current portion	1,649
Deferred revenue, current portion	11,092	13,892
Total current liabilities	99,718	82,002
Senior secured notes, net	247,386	246,950
Operating lease liabilities, less current portion	95,024
Liability related to the sale of future royalties, net	80,837	82,911
Deferred revenue, less current portion	9,340	10,744
Other long-term liabilities	666	9,990
Total liabilities	532,971	432,597
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.0001 par value; 10,000 shares authorized; no shares designated or outstanding at March 31, 2019 or December 31, 2018	0	0
Common stock, $0.0001 par value; 300,000 shares authorized; 174,228 shares and 173,530 shares outstanding at March 31, 2019 and December 31, 2018, respectively	17	17
Capital in excess of par value	3,178,773	3,147,925
Accumulated other comprehensive loss	(2,716)	(6,316)
Accumulated deficit	(1,542,563)	(1,424,051)
Total stockholders’ equity	1,633,511	1,717,575
Total liabilities and stockholders’ equity	$ 2,166,482	$ 2,150,172