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Property, Plant and Equipment (Tables)
 12 Months Ended
Dec. 31, 2018
Property Plant And Equipment [Abstract]  
Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

 

 

 

December 31,

 

 

 

2018

 

 

2017

 

Building and leasehold improvements

 

$

77,771

 

 

$

81,444

 

Laboratory equipment

 

 

33,806

 

 

 

31,214

 

Computers, furniture, and other

 

 

31,354

 

 

 

27,800

 

Manufacturing equipment

 

 

21,339

 

 

 

20,695

 

Depreciable property, plant and equipment at cost

 

 

164,270

 

 

 

161,153

 

Less: accumulated depreciation

 

 

(120,507

)

 

 

(115,090

)

Depreciable property, plant and equipment, net

 

 

43,763

 

 

 

46,063

 

Construction-in-progress

 

 

5,088

 

 

 

1,400

 

Property, plant and equipment, net

 

$

48,851

 

 

$

47,463