Organization and Summary of Significant Accounting Policies - Impact of Adoption of ASC 606 on Condensed Consolidated Balance Sheet and Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
Condensed Consolidated Balance Sheet data
Accounts receivable, net	$ 35,315		$ 35,315		$ 5,014
Deferred revenue, current portion	17,988		17,988		18,949
Deferred revenue, less current portion	13,780		13,780		19,021
Accumulated deficit	(1,229,696)		(1,229,696)		$ (2,117,941)
Condensed Consolidated Statement of Operations data
Total revenue	1,087,717	$ 34,589	1,125,735	$ 59,317
Royalty [Member]
Condensed Consolidated Statement of Operations data
Total revenue	8,563	7,434	19,639	14,651
License, Collaboration and Other Revenue [Member]
Condensed Consolidated Statement of Operations data
Total revenue	1,064,246	4,824	1,077,973	10,916
Product Sales [Member]
Condensed Consolidated Statement of Operations data
Total revenue	5,863	$ 15,693	12,158	$ 20,449
ASC 606 [Member] | Adjustments [Member]
Condensed Consolidated Balance Sheet data
Accounts receivable, net	(9,875)		(9,875)
Deferred revenue, current portion	650		650
Deferred revenue, less current portion	978		978
Accumulated deficit	(11,503)		(11,503)
Condensed Consolidated Statement of Operations data
Total revenue	1,314		1,195
ASC 606 [Member] | Adjustments [Member] | Royalty [Member]
Condensed Consolidated Statement of Operations data
Total revenue	1,201		869
ASC 606 [Member] | Adjustments [Member] | License, Collaboration and Other Revenue [Member]
Condensed Consolidated Statement of Operations data
Total revenue	305		518
ASC 606 [Member] | Adjustments [Member] | Product Sales [Member]
Condensed Consolidated Statement of Operations data
Total revenue	(192)		(192)
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member]
Condensed Consolidated Balance Sheet data
Accounts receivable, net	25,440		25,440
Deferred revenue, current portion	18,638		18,638
Deferred revenue, less current portion	14,758		14,758
Accumulated deficit	(1,241,199)		(1,241,199)
Condensed Consolidated Statement of Operations data
Total revenue	1,089,031		1,126,930
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Royalty [Member]
Condensed Consolidated Statement of Operations data
Total revenue	9,764		20,508
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | License, Collaboration and Other Revenue [Member]
Condensed Consolidated Statement of Operations data
Total revenue	1,064,551		1,078,491
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Product Sales [Member]
Condensed Consolidated Statement of Operations data
Total revenue	$ 5,671		$ 11,966