Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2016

Property Plant And Equipment [Abstract]

Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2016			2015
Building and leasehold improvements	$	75,137		$	77,665
Manufacturing equipment		44,237			35,631
Laboratory equipment		27,424			27,309
Furniture, fixtures and other equipment		26,590			24,987
Depreciable property, plant and equipment at cost		173,388			165,592
Less: accumulated depreciation		(111,243	)		(102,712	)
Depreciable property, plant and equipment, net		62,145			62,880
Construction-in-progress		3,456			8,456
Property, plant and equipment, net	$	65,601		$	71,336