Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Revenue:
Product sales and royalty revenue	$ 7,427	$ 6,172	$ 27,239	$ 17,980
Non-cash royalty revenue related to sale of future royalties	6,050	6,143	14,752	16,753
License, collaboration and other revenue	46,475	120,556	149,423	146,422
Total revenue	59,952	132,871	191,414	181,155
Operating costs and expenses:
Cost of goods sold	6,760	9,220	25,738	22,235
Research and development	43,229	34,200	135,652	109,240
General and administrative	9,544	9,130	30,031	28,677
Total operating costs and expenses	59,533	52,550	191,421	160,152
Income (loss) from operations	419	80,321	(7)	21,003
Non-operating income (expense):
Interest expense	(4,202)	(4,391)	(12,491)	(13,412)
Non-cash interest expense on liability related to sale of future royalties	(5,226)	(5,203)	(15,428)	(15,725)
Interest income and other income (expense), net	898	126	1,355	535
Total non-operating expense, net	(8,530)	(9,468)	(26,564)	(28,602)
Income (loss) before provision for income taxes	(8,111)	70,853	(26,571)	(7,599)
Provision for income taxes	92	248	469	634
Net income (loss)	$ (8,203)	$ 70,605	$ (27,040)	$ (8,233)
Net income (loss) per share:
Basic	$ (0.06)	$ 0.55	$ (0.21)	$ (0.07)
Diluted	$ (0.06)	$ 0.53	$ (0.21)	$ (0.07)
Weighted average shares outstanding used in computing net income (loss) per share:
Basic	132,631	127,504	131,882	126,043
Diluted	132,631	132,177	131,882	126,043